Cd86 - CD86 antigen Gene

Also Known as B7; B70; MB7; B7-2; B7.2; CLS1; Ly58; ETC-1; Ly-58; MB7-2; Cd28l2; TS/A-2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12524

Summary

Predicted to enable signaling receptor binding activity. Involved in several processes, including CD40 signaling pathway; activation of Phospholipase C activity; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; defense response to virus; and positive regulation of T cell proliferation. Located in external side of plasma membrane and intracellular membrane-bounded organelle. Is expressed in central nervous system and retina. Used to study Guillain-Barre syndrome. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; autoimmune disease (multiple); chronic lymphocytic leukemia; chronic obstructive pulmonary disease; and systemic scleroderma. Orthologous to human CD86 (CD86 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd86 Products (1)

mRNA	Protein	Name
NM_019388.3	NP_062261.3	T-lymphocyte activation antigen CD86 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23241883	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within B cell activation	IDA IDA: Inferred from direct assay	19734906	MGI
involved in B cell activation	IDA IDA: Inferred from direct assay	23241883	MGI
acts upstream of or within cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	19047410	MGI
acts upstream of or within defense response to virus	IDA IDA: Inferred from direct assay	17277142	MGI
acts upstream of or within positive regulation of T cell proliferation	IGI IGI: Inferred from genetic interaction	23793062	MGI
involved in positive regulation of immunoglobulin production	IDA IDA: Inferred from direct assay	23241883	MGI
involved in positive regulation of non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	23241883	MGI
involved in toll-like receptor 3 signaling pathway	IMP IMP: Inferred from mutant phenotype	25158758	MGI
acts upstream of or within toll-like receptor signaling pathway	IDA IDA: Inferred from direct assay	19734906	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	12801066	MGI
located in intracellular membrane-bounded organelle	IDA IDA: Inferred from direct assay	16708399	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
T-lymphocyte activation antigen CD86	activation B7-2 antigen early T cell costimulatory molecule-1

Recombinant Cd86 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7635	B7-2/CD86 Protein, Mouse (HEK293, Fc)	P42082 (V26-E245)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7638	B7-2/CD86 Protein, Mouse (HEK293, His)	P42082 (V24-K244)	≥ 95%, as determined by reducing SDS-PAGE.

Cd86 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810806	CD86 Antibody (YA10049)	ICC/IF, FC	Mouse
HY-P83710M	Rat Anti-Mouse CD86 Antibody (FITC)(YA3447)	FC	Mouse

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N6664	Gum arabic		/	Phase 3
HY-115870	AZD8154	Inhibitor	99.88%	Phase 2
HY-141677A	INCB059872 dihydrochloride	Inhibitor	99.64%	Phase 2
HY-141677C	INCB059872 TFA	Inhibitor	/	Phase 2
HY-W016773	1,10-Decanediol		99.95%	Phase 1

Inhibitory Antibodies (7)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991424	GSK2618960	Inhibitor	95.66%	Phase 2
HY-P99821	Ravagalimab	Inhibitor	99.31%	Phase 2
HY-P99809	Quavonlimab	Inhibitor	≥99.0%	Phase 2
HY-P991566	KD6001	Inhibitor	/	Phase 2
HY-P991952	ADU-1604	Inhibitor	/	Phase 1
HY-P991961	REGN4659	Inhibitor	/	Phase 1
HY-P991366	IBI-397	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (29)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148980A	Polyinosinic acid sodium		91.5%	Unkown
HY-150749A	ODN D-SL03 sodium		98.57%	Unkown
HY-163962	L18I		99.89%	Unkown
HY-W722277A	LCC-12 formate	Inhibitor	99.90%	Unkown
HY-141677	INCB059872	Inhibitor	99.60%	Unkown
HY-138794B	XL177B		99.36%	Unkown
HY-150749	ODN D-SL03	Inducer	99.82%	Unkown
HY-N10116A	Calamenene		/	Unkown
HY-148980	Polyinosinic acid		/	Unkown
HY-141677B	INCB059872 tosylate	Inhibitor	/	Unkown
HY-143410	Anti-inflammatory agent 16	Inhibitor	/	Unkown
HY-144675	LSD1-IN-13	Inhibitor	/	Unkown
HY-144675A	LSD1-IN-13 hydrochloride	Inhibitor	/	Unkown
HY-150740	ODN 21595	Inhibitor	/	Unkown
HY-152201	BTK-IN-18	Inhibitor	/	Unkown
HY-160227	ORN 06	Activator	/	Unkown
HY-161833	HSP90-IN-31	Inhibitor	/	Unkown
HY-169819	Calcium influx inducer compound 634		/	Unkown
HY-170403	LSD1-IN-38	Inhibitor	/	Unkown
HY-173070	TLR7 agonist 29		/	Unkown
HY-179336	TLR7/8 agonist 14		/	Unkown
HY-181781	LSD1-IN-48		/	Unkown
HY-RS02274	CD86 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W016773S	1,10-Decanediol-d20		/	Unkown
HY-150740A	ODN 21595 sodium	Inhibitor	/	Unkown
HY-168384	M04		/	Unkown
HY-184441	CD28-IN-4	Inhibitor	/	Unkown
HY-RS16645	Cd86 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23079	Cd86 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990260	Anti-Mouse CD86/B7-2 Antibody (GL-1)	Inhibitor	99.17%	Unkown
HY-P990127	Anti-Mouse CD80/B7-1 Antibody (RM80)	Inhibitor	95%	Unkown
HY-P990261	Anti-Mouse CD83 Antibody (Michel-17)	Inhibitor	98.722%	Unkown
HY-P991759	Anti-Rat CD86 Antibody (OX-48)	Inhibitor	/	Unkown
HY-P991777	Anti-Mouse CD86/B7-2 Antibody (2D10)	Inhibitor	/	Unkown
HY-P991908	Anti-CD86 Antibody (3D1)		/	Unkown
HY-P991918	KHK2840	Agonist	/	Unkown
HY-P992408	MEDI-5083		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cd86	NCBI	NCBI:942