1. Epigenetics
  2. Histone Demethylase
  3. LSD1-IN-13

LSD1-IN-13 

Cat. No.: HY-144675
Handling Instructions

LSD1-IN-13 (compound 7e) is an orally active and potent LSD1 inhibitor, with an IC50 of 24.43 nM. LSD1-IN-13 can activate CD86 expression, with an EC50 of 470 nM. LSD1-IN-13 induces differentiation of AML (acute myeloid leukemia) cell lines.

For research use only. We do not sell to patients.

LSD1-IN-13 Chemical Structure

LSD1-IN-13 Chemical Structure

CAS No. : 2170212-33-4

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Description

LSD1-IN-13 (compound 7e) is an orally active and potent LSD1 inhibitor, with an IC50 of 24.43 nM. LSD1-IN-13 can activate CD86 expression, with an EC50 of 470 nM. LSD1-IN-13 induces differentiation of AML (acute myeloid leukemia) cell lines[1].

IC50 & Target

IC50: 24.43 ± 1.08 nM (LSD1), 5.00 ± 0.28 μM (LSD2), >100 μM (MAO-A), >100 μM (MAO-B)[1]

In Vitro

LSD1-IN-13 (compound 7e) shows good selectivity over LSD2 (205-fold) and MAOs (>4000-fold)[1].
LSD1-IN-13 shows potent and selective antiproliferative activity in MV-4-11, with an IC50 of 1.36 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

LSD1-IN-13 (compound 7e) (MV-4-11 xenograft mice, 0-20 mg/kg, Orally, daily for 15 days) suppresses tumor growth significantly in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

411.56

Formula

C23H29N3O2S

CAS No.
SMILES

O=S(N1CCC2=C1C=CC([[email protected]]3[[email protected]](NCC4CCNCC4)C3)=C2)(C5=CC=CC=C5)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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LSD1-IN-13
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