2170212-33-4
2170212-33-4
Chemical Structure
LSD1-IN-13
- CAS No.: 2170212-33-4
- Formula:C23H29N3O2S
- Molecular Weight:411.56
IUPAC Name: (1R,2S)-2-(1-(phenylsulfonyl)indolin-5-yl)-N-(piperidin-4-ylmethyl)cyclopropan-1-amine
InChIKey: DICMSESOTHCHTP-FCHUYYIVSA-N
SMILES: O=S(N1CCC2=C1C=CC([C@H]3[C@H](NCC4CCNCC4)C3)=C2)(C5=CC=CC=C5)=O
Biological Activity: LSD1-IN-13 (compound 7e) is an orally active and potent LSD1 inhibitor, with an IC50 of 24.43 nM. LSD1-IN-13 can activate CD86 expression, with an EC50 of 470 nM. LSD1-IN-13 induces differentiation of AML (acute myeloid leukemia) cell lines[1].
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LSD1-IN-13 | LSD1-IN-13 (compound 7e) is an orally active and potent LSD1 inhibitor, with an IC50 of 24.43 nM. LSD1-IN-13 can activate CD86 expression, with an EC50 of 470 nM. LSD1-IN-13 induces differentiation of AML (acute myeloid leukemia) cell lines. | |||||||||||||||||||||
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