CD86 Antibody (YA6374)
(Synonyms: CD28LG2; FUN1; LAB72; Activation B7 2 antigen; Activation B7-2 antigen 3; CD86_HUMAN; Activation B7-2 antigen; Activation B72 antigen; B lymphocyte activation antigen B7 2; B lymphocyte activation antigen B72; B-lymphocyte activation antigen B7-2 2; B-lymphocyte activation antigen B7-2; B7 2; B7 2 antigen; B7; B7-2; B7.2; B70; B72 antigen; BU63; CD 86; CD28 antigen ligand 2 2; CD28 antigen ligand 2; Cd28l2; CD28LG2; CD86 antigen(CD28 antigen ligand 2, B7-2 antigen) 1, 2; CD86 antigen; CD86 molecule; CLS1; CTLA 4 counter receptor B7 2; CTLA 4 counter receptor B7.2; CTLA-4 counter-receptor B7.2 2, 3; CTLA4 counter receptor B72; Early T-cell costimulatory molecule 1; ETC-1; FUN 1; LAB72; Ly-58; Ly58; MB7; MB7-2; Membrane glycoprotein; MGC34413; T lymphocyte activation antigen CD86; T-lymphocyte activation antigen CD86; TS/A-2.)CD86 Antibody (YA6374) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD86.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
ICC/IF, FC
-
Reactivity :
Human
-
Formulation:
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1ug/Test | 1:50-200 |
Product Details
CD86 Antibody (YA6374) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD86.
-
Host Rabbit
-
Clonality Monoclonal
-
Species ReactivityHuman
-
Calculated Molecular Weight Predicted band size: 37 kDa
Recombinant human CD86 protein aa 24-239/329
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
CD86 (B7-2) is an immune co-stimulatory molecule expressed on the surface of antigen-presenting cells that regulates T-cell activation through binding to CD28 or CTLA-4 on T cells; it serves as a classic marker in research concerning dendritic cell maturation, macrophage polarization, tumor immunity, autoimmunity, infection, and transplant immunology.
-
Subcellular Localization
Cell membrane; Single-pass type I membrane protein
-
Expression
Tissue_specificity:Expressed on activated B-cells -
Isoforms & Post-Translational Modification
CD86 has 2 isomers: P42082-1: 34666 Da (predicted); P42082-2: 33962 Da (predicted).
Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation -
Subunit
Homodimer. Interacts (via cytoplasmic domain) with PHB1 and PHB2; the interactions increases after priming with CD40.
-
SwissProt ID
-
Synonyms
CD28LG2; FUN1; LAB72; Activation B7 2 antigen; Activation B7-2 antigen 3; CD86_HUMAN; Activation B7-2 antigen; Activation B72 antigen; B lymphocyte activation antigen B7 2; B lymphocyte activation antigen B72; B-lymphocyte activation antigen B7-2 2; B-lymphocyte activation antigen B7-2; B7 2; B7 2 antigen; B7; B7-2; B7.2; B70; B72 antigen; BU63; CD 86; CD28 antigen ligand 2 2; CD28 antigen ligand 2; Cd28l2; CD28LG2; CD86 antigen(CD28 antigen ligand 2, B7-2 antigen) 1, 2; CD86 antigen; CD86 molecule; CLS1; CTLA 4 counter receptor B7 2; CTLA 4 counter receptor B7.2; CTLA-4 counter-receptor B7.2 2, 3; CTLA4 counter receptor B72; Early T-cell costimulatory molecule 1; ETC-1; FUN 1; LAB72; Ly-58; Ly58; MB7; MB7-2; Membrane glycoprotein; MGC34413; T lymphocyte activation antigen CD86; T-lymphocyte activation antigen CD86; TS/A-2.
Documentation
[1]. Collins AV, et al. The interaction properties of costimulatory molecules revisited. Immunity. 2002 Aug;17(2):201-10. [Content Brief]
[2]. Lanier LL, et al. CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL. J Immunol. 1995 Jan 1;154(1):97-105. [Content Brief]
Powered by Bioz
