HNRNPA2B1 Protein, Human (His)
Based on 1 Customer Validation
Heterogeneous nuclear ribonucleoproteins A2/B1 is an important RNA-binding protein that affects the RNA processing, splicing, transport and stability of many genes. Heterogeneous nuclear ribonucleoproteins A2/B1 is expressed during proliferation and metastasis of various cancer types and promotes such processes. HNRNPA2B1 Protein, Human (His) is the recombinant human-derived HNRNPA2B1 protein, expressed by E. coli , with N-10*His labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
Heterogeneous nuclear ribonucleoproteins A2/B1 is an important RNA-binding protein that affects the RNA processing, splicing, transport and stability of many genes. Heterogeneous nuclear ribonucleoproteins A2/B1 is expressed during proliferation and metastasis of various cancer types and promotes such processes. HNRNPA2B1 Protein, Human (His) is the recombinant human-derived HNRNPA2B1 protein, expressed by E. coli , with N-10*His labeled tag.
Background
Heterogeneous nuclear ribonucleoproteins A2/B1 belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). Heterogeneous nuclear ribonucleoproteins A2/B1 is RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). Heterogeneous nuclear ribonucleoproteins A2/B1 is associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. Heterogeneous nuclear ribonucleoproteins A2/B1 has distinct nucleic acid binding properties. Heterogeneous nuclear ribonucleoproteins A2/B1 has two repeats of quasi-RRM domains that bind to RNAs. Heterogeneous nuclear ribonucleoproteins A2/B1 has been described to generate two alternatively spliced transcript variants which encode different isoforms[1][2][3][4][5].
Technical Parameters
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Species Human
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Source E. coli
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Tag N-10*His
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Accession
I6L957 (M1-Q249)
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Gene ID/
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Molecular Construction
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N-term
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10*His
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HNRNPA2B1 (M1-Q249)
Accession # I6L957 -
C-term
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Protein Length
Full Length
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Synonyms
HNRNPA2B1; HnRNP A2 / HnRNP B1; Prev. HNRPA2B1; IBMPFD2; Heterogeneous Nuclear Ribonucleoproteins A2/B1; HNRPA2; HNRNPA2; HNRPB1; HNRNPB1; SNRPB1; Nuclear Ribonucleoprotein Particle A2 Protein; OPDM2; Epididymis Secretory Sperm Binding Protein; OPMD2; HNR
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AA Sequence
MEREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQEDLEVAILEVAPVMEEEEEDMVVEDLDMATRVGATEVVMTTMEEEIMEVEITMILEIITSNLLTTVQ
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Predicted Molecular Mass
31.9 kDa
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Molecular Weight
Approximately 40 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of 10 mM Tris-HCl, 1 mM EDTA, 6% trehalose, pH 8.0.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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