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Rat Anti-Mouse CD16/32 Antibody (FITC)(YA3449)

(Synonyms: CD16a/b; CD32; CD32A/B; Fc fragment of IgG low affinity IIa/b receptor; Fc fragment of IgG low affinity IIIa/b receptor; Fc fragment of IgG low affinity IIIb receptor; Fc gamma receptor III A/B; FCG2A; FcGR; FCGR2A/BFCGR3; FCGR3A/B; Fc gamma RIIa/b)

Rat Anti-Mouse CD16/32 Antibody (FITC)(YA3449) is a rat-derived and fluorescein isothiocyanate (FITC) IgG2b monoclonal antibody, targeting to CD16/32.

For research use only. We do not sell to patients.
  • Host:

    Rat

  • Isotype:

    IgG2b

  • Application:

    FC

  • Reactivity :

    Mouse

  • Formulation:

    Supplied in PBS with 0.05% Proclin300, 1% BSA.

  • Conjugation:
    FITC
  • Rat Anti-Mouse CD16/32 Antibody (FITC)(YA3449) Product Image
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Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
FC Info
FC: Flow Cytometry
Dilution Ratio 5μL per test for million cells or whole blood in 100 μL volume.

Product Details

Description

Rat Anti-Mouse CD16/32 Antibody (FITC)(YA3449) is a rat-derived and fluorescein isothiocyanate (FITC) IgG2b monoclonal antibody, targeting to CD16/32.

  • Host Rat
  • Clonality Monoclonal
  • Species Reactivity
    Mouse
  • Observed Molecular Weight
    Observed band size: 40 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 29 kDa
Species Reactivity Database
Immunogen

A synthesized peptide derived from Mouse CD16/32

Conjugation

FITC

Modification

Unmodified

Isotype

IgG2b

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS with 0.05% Proclin300, 1% BSA.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at 2-8°C for 1 year, protect from light, do not freeze.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    Rat Anti-Mouse CD16/32 is a P08508: Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor which binds to IgG1, IgG2a and IgG2b. Mediates neutrophil activation by IgG complexes redundantly with Fcgr4
    P08101: Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of antigen-antibody complexes from the circulation and modulation of antibody production by B-cells. Isoform IIB1 and isoform IIB1' form caps but fail to mediate endocytosis or phagocytosis. Isoform IIB2 can mediate the endocytosis of soluble immune complexes via clathrin-coated pits. Isoform IIB1 and isoform IIB2 can down-regulate B-cell, T-cell, and mast cell activation when coaggregated to B-cell receptors for AG (BCR), T-cell receptors for AG (TCR), and Fc receptors, respectively
    [1][2].

  • Subcellular Localization

    P08508: Cell membrane; Single-pass type I membrane protein
    P08101: Cell membrane; Single-pass type I membrane protein; Cytoplasm, cytoskeleton; Secreted

  • Expression


    Tissue_specificity: P08101: Widely expressed by cells of hemopoietic origin. The isoforms are differentially expressed. Isoform IIB1 is preferentially expressed by cells of the lymphoid lineage, isoform IIB2 by cells of the myeloid lineage, and isoform IIB3 is released by macrophages and is present in the serum. Isoform IIB1' is expressed in myeloid and lymphoid cell lines, in normal spleen cells, and in resting or LPS-activated B-cells but is not detected in mesenteric lymph node cells

  • Subunit

    P08508: Interacts with INPP5D/SHIP1
    P08101: Interacts with FGR (By similarity). Interacts with LYN

  • SwissProt ID

    P08508 / P08101

  • Gene ID
    14130 [NCBI] / 14131 [NCBI]
  • Synonyms

    CD16a/b; CD32; CD32A/B; Fc fragment of IgG low affinity IIa/b receptor; Fc fragment of IgG low affinity IIIa/b receptor; Fc fragment of IgG low affinity IIIb receptor; Fc gamma receptor III A/B; FCG2A; FcGR; FCGR2A/BFCGR3; FCGR3A/B; Fc gamma RIIa/b

Rat Anti-Mouse CD16/32 Antibody (FITC)(YA3449) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • Rat Anti-Mouse CD16/32 Antibody (FITC)(YA3449) Product Image
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  • Rat Anti-Mouse CD16/32 Antibody (FITC)(YA3449) Product Image