Fcgr2b - Fc receptor, IgG, low affinity IIb Gene

Also Known as CD32; Fcgr2; Fcr-2; Fcr-3; Ly-17; LyM-1; Lym-1; fcRII; FcgRII; Fcgr2a; Ly-m20; Fc[g]RII; F630109E10Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14130

Summary

Enables IgG binding activity. Involved in several processes, including cellular response to amyloid-beta; nervous system development; and regulation of cellular response to stress. Acts upstream of or within several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; negative regulation of immune effector process; and regulation of phagocytosis. Located in cell body; dendritic spine; and external side of plasma membrane. Is integral component of membrane. Is expressed in liver and spleen. Used to study malaria and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dengue disease (multiple); hematologic Cancer (multiple); leukopenia (multiple); and malaria (multiple). Orthologous to several human genes including FCGR2B (Fc fragment of IgG receptor IIb). [provided by Alliance of Genome Resources, Apr 2022]

Fcgr2b Products (2)

mRNA Protein Name
NM_001077189.1 NP_001070657.1 low affinity immunoglobulin gamma Fc region receptor II-b isoform 1
NM_010187.2 NP_034317.1 low affinity immunoglobulin gamma Fc region receptor II-b isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables IgG binding IDA
IDA: Inferred from direct assay
9551950 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12893283 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of B cell proliferation IMP
IMP: Inferred from mutant phenotype
12385742 MGI
involved in Fc receptor-mediated immune complex endocytosis IDA
IDA: Inferred from direct assay
28389502 MGI
acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II IMP
IMP: Inferred from mutant phenotype
14643301 MGI
acts upstream of or within cell surface receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
8552190 MGI
involved in cellular response to amyloid-beta IMP
IMP: Inferred from mutant phenotype
23921129 MGI
acts upstream of or within cellular response to molecule of bacterial origin IMP
IMP: Inferred from mutant phenotype
12385742 MGI
involved in cerebellum development IMP
IMP: Inferred from mutant phenotype
17502348 MGI
acts upstream of or within defense response IMP
IMP: Inferred from mutant phenotype
11994421 MGI
involved in dendrite development IMP
IMP: Inferred from mutant phenotype
17502348 MGI
acts upstream of establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
12385742 MGI
acts upstream of or within immunoglobulin mediated immune response IMP
IMP: Inferred from mutant phenotype
10395649 MGI
acts upstream of immunoglobulin production IMP
IMP: Inferred from mutant phenotype
12385742 MGI
acts upstream of interleukin-10 production IMP
IMP: Inferred from mutant phenotype
12385742 MGI
NOT acts upstream of or within mast cell activation IDA
IDA: Inferred from direct assay
8769481 MGI
acts upstream of or within negative regulation of B cell proliferation IMP
IMP: Inferred from mutant phenotype
8552190 MGI
acts upstream of or within negative regulation of acute inflammatory response to antigenic stimulus IMP
IMP: Inferred from mutant phenotype
12385742 MGI
acts upstream of or within negative regulation of humoral immune response mediated by circulating immunoglobulin IMP
IMP: Inferred from mutant phenotype
12385742 MGI
acts upstream of or within negative regulation of immune response IMP
IMP: Inferred from mutant phenotype
8552190 MGI
acts upstream of or within negative regulation of immunoglobulin production IMP
IMP: Inferred from mutant phenotype
12385742 MGI
acts upstream of or within negative regulation of inflammatory response to antigenic stimulus IMP
IMP: Inferred from mutant phenotype
16492738 MGI
acts upstream of or within negative regulation of interleukin-10 production IMP
IMP: Inferred from mutant phenotype
12385742 MGI
acts upstream of or within negative regulation of phagocytosis IMP
IMP: Inferred from mutant phenotype
12385742 MGI
acts upstream of or within negative regulation of type I hypersensitivity IMP
IMP: Inferred from mutant phenotype
8552190 MGI
acts upstream of phagocytosis IMP
IMP: Inferred from mutant phenotype
12385742 MGI
acts upstream of or within phagocytosis, engulfment IDA
IDA: Inferred from direct assay
8769481 MGI
involved in positive regulation of DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
23921129 MGI
involved in positive regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
23921129 MGI
acts upstream of or within positive regulation of phagocytosis IDA
IDA: Inferred from direct assay
8769481 MGI
involved in positive regulation of response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
23921129 MGI
involved in regulation of dendritic spine maintenance IMP
IMP: Inferred from mutant phenotype
23921129 MGI
involved in regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
23921129 MGI
involved in regulation of long-term neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
23921129 MGI
acts upstream of or within response to bacterium IMP
IMP: Inferred from mutant phenotype
12385742 MGI
Cellular Component GO Annotation Evidence References Source
located in cell body IDA
IDA: Inferred from direct assay
17502348 MGI
located in dendritic spine IDA
IDA: Inferred from direct assay
17502348 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
8552190 MGI
located in membrane IDA
IDA: Inferred from direct assay
8552190 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
17502348 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

low affinity immunoglobulin gamma Fc region receptor II-b

  • Fc gamma RIIB

  • Fc-gamma-RII

  • FcgammaRIIB

  • fc gamma receptor IIB

  • fc-gamma RII

  • fc-gamma-RIIB

  • igG Fc receptor II beta

  • low affinity immunoglobulin gamma Fc region receptor II

  • lymphocyte antigen 17

Recombinant Fcgr2b Proteins

Cat. No. Product Name Accession Purity
HY-P72735 Fc gamma RIIB/CD32b Protein, Mouse (HEK293, His) P08101-1 (T30-P210) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75649 Fc gamma RIIB/CD32b Protein, Mouse (Biotinylated, HEK293, His-Avi) P08101-1 (T30-R207) ≥ 95%, as determined by reducing SDS-PAGE.

Fcgr2b Antibodies

Cat. No. Product Name Application Reactivity
HY-P83712M Rat Anti-Mouse CD16/32 Antibody (FITC)(YA3449) FC Mouse

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04829 FCGR2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17922 Fcgr2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24392 Fcgr2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992211 Anti-CD32b/FCGR2B Antibody (2B6) Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fcgr2b NCBI NCBI:2213