FCGR2B - Fc gamma receptor IIb Gene

Also Known as CD32; FCG2; CD32B; FCGR2; IGFR2; FCGR2C; FcGRIIB; FcRII-c; FcgammaRIIb

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2213

About FCGR2B

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:161,647,243-161,678,654 (from NCBI)

This gene has 6 transcripts (splice variants), 264 orthologues, 17 paralogues and is associated with 55 phenotypes. Biased expression in placenta (RPKM 92.9), appendix (RPKM 9.6) and 6 other tissues.

Summary

The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

FCGR2B Products (13)

mRNA	Protein	Name
NM_001002273.3	NP_001002273.1	low affinity immunoglobulin gamma Fc region receptor II-b isoform 2 precursor
NM_001002274.3	NP_001002274.1	low affinity immunoglobulin gamma Fc region receptor II-b isoform 3 precursor
NM_001002275.3	NP_001002275.1	low affinity immunoglobulin gamma Fc region receptor II-b isoform 4 precursor
NM_001190828.2	NP_001177757.1	low affinity immunoglobulin gamma Fc region receptor II-b isoform 5
NM_001386000.1	NP_001372929.1	low affinity immunoglobulin gamma Fc region receptor II-b isoform 6
NM_001386001.1	NP_001372930.1	low affinity immunoglobulin gamma Fc region receptor II-b isoform 7
NM_001386002.1	NP_001372931.1	low affinity immunoglobulin gamma Fc region receptor II-b isoform 8
NM_001386003.1	NP_001372932.1	low affinity immunoglobulin gamma Fc region receptor II-b isoform 9 precursor
NM_001386004.1	NP_001372933.1	low affinity immunoglobulin gamma Fc region receptor II-b isoform 10
NM_001386005.1	NP_001372934.1	low affinity immunoglobulin gamma Fc region receptor II-b isoform 11 precursor
NM_001386006.1	NP_001372935.1	low affinity immunoglobulin gamma Fc region receptor II-b isoform 12
NM_001394477.1	NP_001381406.1	low affinity immunoglobulin gamma Fc region receptor II-b isoform 1 precursor
NM_004001.5	NP_003992.3	low affinity immunoglobulin gamma Fc region receptor II-b isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables IgG binding	IDA IDA: Inferred from direct assay	2142460	GOA
enables amyloid-beta binding	IPI IPI: Inferred from physical interaction	23921129	GOA
enables low-affinity IgG receptor activity	IDA IDA: Inferred from direct assay	2142460	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8577729	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	23921129	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Fc-gamma receptor signaling pathway	IDA IDA: Inferred from direct assay	2142460	GOA
involved in immune effector process	IDA IDA: Inferred from direct assay	2142460	GOA
involved in negative regulation of B cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	24169826	GOA
involved in phagocytosis	IDA IDA: Inferred from direct assay	2142460	GOA
involved in receptor-mediated endocytosis	IDA IDA: Inferred from direct assay	2142460	GOA
involved in regulation of dendritic spine maintenance	IGI IGI: Inferred from genetic interaction	23921129	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	2142460	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FCGR2B Protein Structure

Ig_2

0
100
200
310 a.a.

Protein Preferred Names	Protein Names
low affinity immunoglobulin gamma Fc region receptor II-b	CDw32

FCGR2B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FCGR2B	P31994	INPP5D	Homo sapiens	Q92835	Pull Down	10382761
Intra	FCGR2B	P31994	IGHG1	Homo sapiens	P01857	SPR	11567028
Intra	FCGR2B	P31994	IGHG1	Homo sapiens	P01857	ITC	11567028
Intra	FCGR2B	P31994	NCK1	Homo sapiens	P16333	Peptide Array	17474147
Intra	FCGR2B	P31994	PTPN6	Homo sapiens	P29350	Pull Down	9603468
Intra	FCGR2B	P31994	PLCG1	Homo sapiens	P19174	Peptide Array	17474147

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FCGR2B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70491	Fc gamma RIIB/CD32b Protein, Human (HEK293, His)	P31994-1 (T43-P217)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75211	Fc gamma RIIB/CD32b Protein, Human (Biotinylated, HEK293, His-Avi)	P31994-2/NP_001002274.1 (A46-I224)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78424	Fc gamma RIIB/CD32b Protein, Human (HEK293, His-Avi)	P31994-1 (A46-P217)	≥ 95%, as determined by Bis-Tris PAGE.

FCGR2B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81870	CD32B Antibody (YA1615)	WB, IHC-P	Human, Rat
HY-P81870A	CD32B Antibody (YA1615)(PBS only)	WB, IHC-P	Human, Rat
HY-P84987	CD32B Antibody (YA4679)	ELISA, FC	Human

Related Diseases

Diseases	Alias
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
Measles	Rubeola Morbilli Measles Nos Koplik Spots
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Mast Cell Neoplasm	Mastocytoma Mast Cell Proliferative Disease Mast Cell Tumor Benign Mastocytoma
Autoimmune Glomerulonephritis
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Follicular Lymphoma	Lymphoma, Follicular Lymphoma Follicular Brill-Symmers' Disease Large Cell Follicular Non-Hodgkin Lymphoma Diffuse Follicle Centre Lymphoma Diffuse Follicular Lymphoma Nos Follicular Nodular Non-Hodgkin Lymphoma, Unspecified Follicular Large Cell Cleaved Or Noncleaved Lymphoma Large Cell Follicular Noncleaved Lymphoma Follicular Lymphoma With Or Without Diffuse Areas Histiocytic Follicular Lymphoma Histiocytic Nodular Lymphoma Histiocytic Nodular Malignant Lymphoma Large Cell Follicular Lymphoma Large Cell Noncleaved Follicular Lymphoma Large Cell Noncleaved Follicular Malignant Lymphoma Nodular Reticulum Cell Sarcoma Noncleaved Follicular Lymphoma
Autoimmune Disease Of Urogenital Tract
Arthus Reaction	Arthus Phenomenon Arthus Type Urticaria
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Anti-Basement Membrane Glomerulonephritis	Anti-Gbm Glomerulonephritis
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Primary Thrombocytopenia
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Thrombocytopenia Due To Platelet Alloimmunization	Immune Thrombocytopenia Autoimmune Thrombocytopenia Immune Thrombocytopenic Purpura Itp Auto-Immune Thrombocytopenia Thrombocytopenia Due To Immune Destruction Autoimmune Thrombocytopenic Purpura Idiopathic Thrombocytopenic Purpura Werlhof Disease
Goodpasture Syndrome	Anti-Glomerular Basement Membrane Disease Anti-Gbm Disease Pulmonary Renal Syndrome Anti-Glomerular Basement Membrane Antibody Disease Glomerulonephritis - Pulmonary Hemorrhage Rapidly Progressive Glomerulonephritis With Pulmonary Hemorrhage Anti-Gbm Syndrome Goodpasture'S Syndrome Anti-Basement Membrane Glomerulonephritis
Demyelinating Polyneuropathy	Peripheral Demyelinating Neuropathy Demyelinating Peripheral Neuropathy
Thrombocytopenic Purpura, Autoimmune	Idiopathic Thrombocytopenic Purpura Autoimmune Thrombocytopenic Purpura Immune Thrombocytopenic Purpura Itp Idiopathic Purpura AITP Ideopath Thrombocytopenic Pur Primary Thrombocytopenic Purpura Werlhof'S Disease Thrombocytopenic Purpura Autoimmune Purpura Thrombocytopenic Idiopathic Purpura, Thrombocytopenic, Idiopathic Autoimmune Thrombocytopenia Thrombocytopenia Due To Platelet Alloimmunization Idiopathic Thrombocytopenia Idiopathic Thrombocytopenia Purpura Frank'S Essential Thrombocytopenia Itp - [Idiopathic Thrombocytopenia Purpura] Werlhof Disease Primary Autoimmune Thrombocytopenic Purpura Haemorrhagic Purpura Essential Thrombocytopenia Purpura Haemorrhagica
Autoimmune Neuropathy
Hypersensitivity Reaction Type Iii Disease	Immune Complex Diseases Immune Complex Disease Type Iii Hypersensitivity Reaction Disease
Autoimmune Disease Of Blood
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04829	FCGR2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17922	Fcgr2b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24392	Fcgr2b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992211	Anti-CD32b/FCGR2B Antibody (2B6)	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FCGR2B	MGD	MGI:95499
Rattus norvegicus	FCGR2B	RGD	RGD:631331