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  4. Fc gamma RII/CD32
  5. FcγRIIB/CD32b
  6. Fc gamma RIIB/CD32b Protein, Mouse (Biotinylated, HEK293, His-Avi)

Fc gamma RIIB/CD32b Protein, Mouse (Biotinylated, HEK293, His-Avi)

Cat. No.: HY-P75649
Handling Instructions

Fc gamma RIIB/CD32b protein is essential for IgG binding activity and participates in immune responses and various processes. It plays a role in antigen processing and presentation, negative regulation of immune processes, and phagocytosis. Fc gamma RIIB/CD32b Protein, Mouse (Biotinylated, HEK293, His-Avi) is the recombinant mouse-derived Fc gamma RIIB/CD32b protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of Fc gamma RIIB/CD32b Protein, Mouse (Biotinylated, HEK293, His-Avi) is 217 a.a., with molecular weight of 38-43 kDa.

For research use only. We do not sell to patients.

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Description

Fc gamma RIIB/CD32b protein is essential for IgG binding activity and participates in immune responses and various processes. It plays a role in antigen processing and presentation, negative regulation of immune processes, and phagocytosis. Fc gamma RIIB/CD32b Protein, Mouse (Biotinylated, HEK293, His-Avi) is the recombinant mouse-derived Fc gamma RIIB/CD32b protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of Fc gamma RIIB/CD32b Protein, Mouse (Biotinylated, HEK293, His-Avi) is 217 a.a., with molecular weight of 38-43 kDa.

Background

Fc gamma RIIB/CD32b Protein plays a crucial role by enabling IgG binding activity, indicating its involvement in immune responses. Engaged in diverse processes such as cellular response to amyloid-beta, nervous system development, and regulation of cellular response to stress, the protein acts upstream of or within processes including antigen processing and presentation of exogenous peptide antigen via MHC class II, negative regulation of immune effector processes, and regulation of phagocytosis. It is strategically located in the cell body, dendritic spine, and the external side of the plasma membrane, functioning as an integral component of the membrane. Broadly expressed in tissues such as the kidney (RPKM 19.1), spleen (RPKM 16.7), and 21 other tissues, Fc gamma RIIB/CD32b demonstrates its significance in immune regulation across various physiological contexts. The human ortholog(s) of this gene have been implicated in several diseases, including autoimmune diseases, dengue disease, hematologic cancers, leukopenia, and malaria, underscoring its critical role in health and disease.

Species

Mouse

Source

HEK293

Tag

C-Avi;C-His

Accession

NP_001070657 (M1-R217)

Gene ID

14130  [NCBI]

Molecular Construction
N-term
CD32b (M1-R217)
Accession # NP_001070657
Avi-His
C-term
Synonyms
Low Affinity Immunoglobulin Gamma Fc Region Receptor II-b; IgG Fc Receptor II-b; CDw32; FcRII-b; CD32; FCGR2B; FCG2; IGFR2
Molecular Weight

38-43 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
Fc gamma RIIB/CD32b Protein, Mouse (Biotinylated, HEK293, His-Avi)
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HY-P75649
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