CEACAM8/CD66b Protein, Canine (HEK293, His)
CEACAM8/CD66b protein is a cell surface glycoprotein that promotes calcium-independent heterophil cell adhesion to other carcinoembryonic antigen-related cell adhesion molecules, particularly CEACAM6, in activated neutrophils Especially obvious. CEACAM8/CD66b Protein, Canine (HEK293, His) is the recombinant canine-derived CEACAM8/CD66b protein, expressed by HEK293 , with C-His labeled tag.
- Species: Canine
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
CEACAM8/CD66b protein is a cell surface glycoprotein that promotes calcium-independent heterophil cell adhesion to other carcinoembryonic antigen-related cell adhesion molecules, particularly CEACAM6, in activated neutrophils Especially obvious. CEACAM8/CD66b Protein, Canine (HEK293, His) is the recombinant canine-derived CEACAM8/CD66b protein, expressed by HEK293 , with C-His labeled tag.
Background
CEACAM8/CD66b protein, a cell surface glycoprotein, actively contributes to cell adhesion in a calcium-independent manner. It primarily mediates heterophilic cell adhesion, forming interactions with other carcinoembryonic antigen-related cell adhesion molecules, including CEACAM6. Notably, the heterophilic interaction with CEACAM8 takes place specifically in activated neutrophils. CEACAM8 operates as a monomer and also forms heterodimers with CEACAM6, engaging in heterodimerization through its Ig-like V-type domain. This emphasizes its role as a versatile cell adhesion molecule, participating in interactions with various partners and highlighting its significance in diverse cellular contexts, particularly in activated neutrophils and during heterophilic adhesion with other CEACAM family members.
Technical Parameters
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Species Canine
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Source HEK293
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Tag C-8*His
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Accession
XP_038509497.1 (Q35-G424)
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Molecular Construction
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N-term
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CEACAM8 (Q35-G424)
Accession # XP_038509497.1 -
8*His
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C-term
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Protein Length
Partial
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Synonyms
CEACAM8; Carcinoembryonic Antigen CGM6; Prev. CGM6; CDNA, FLJ93041, Homo Sapiens Carcinoembryonic Antigen-Related Cell Adhesionmolecule 8 (CEACAM8), MRNA; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 8; Carcinoembryonic Antigen Gene Family Memb
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AA Sequence
QVTVESVPPNAAEGKDALLRVLNLPGDTASLTWFKGETVLPTHKILLYVIDTKITTPGPAYSGRETIYPNGSLLFQNITLNDTGSYILQIINQKFETALVRGQLQVFPELHKPSITSNNSNPVENVDSVVLTCESQTQSTSCLWSVNSKSLPDSPRLELSLDNRTLTVHGVTRNDTGPYECETRNPVSADRSDPFTLNVLYGPDTPTISPPDSYYRLGANLSLSCRTASNPPAQYSWLINGRPQPSTQELFIPNITAKNSGSYTCSVYNNATRLNKTTVKTITVSEPVSQPLLTASNTTVTKDDSVVLTCSSNNTGVSIQWFFNGQILTLTDRMKLSQDNSTLTIDPVRKEDAGKYQCEVSNPVSSNKSDPVRLDVEDDSTEQSSGLPPG
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Predicted Molecular Mass
43.6 kDa
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Molecular Weight
Approximately 68-88 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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