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METTL7A Antibody (YA8008)(PBS only)

(Synonyms: AAM-B)

METTL7A Antibody (YA8008) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to METTL7A.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG2a

  • Application:

    IHC-P

  • Reactivity :

    Human, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • METTL7A Antibody (YA8008)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:2000-2500

Product Details

Description

METTL7A Antibody (YA8008) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to METTL7A.

  • Host Mouse
  • Species Reactivity
    Human, Rat
  • Calculated Molecular Weight Predicted band size: 28.1 kDa
Immunogen

Human recombinant protein fragment corresponding to amino acids 34-104 of human METTL7A produced in E.coli.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG2a

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    METTL7A is a Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes. Able to methylate the N6 position of adenosine residues in long non-coding RNAs (lncRNAs). May facilitate lncRNAs transfer into exosomes at the tumor-stroma interface. Promotes osteogenic and odontogenic differentiation by regulating the expression of genes involved in stem cell differentiation and survival. Targeted from the endoplasmic reticulum to lipid droplets, where it recruits cellular proteins to form functional organelles |(Microbial infection) May be involved in the assembly and release stages of hepatitis C virus (HCV) life cycle and thus play a crucial role in HCV propagation[1][2][3][4][5].

  • Subcellular Localization

    Lipid droplet,Endoplasmic reticulum,Membrane,Microsome,Cytoplasm, cytosol

  • Expression


    Tissue_Specificity: Expressed in the liver
    Induction: Silenced by miR-6807-5p

  • Isoforms & Post-Translational Modification

    Q9H8H3: 244 amino acids, molecular weight 28319 Da.

  • Subunit

    (Microbial infection) Interacts with HCV non-structural protein 4B/NS4B (via C-terminal region); this interaction may promote the recruitment of NS4B in the proximity of lipid droplet

  • SwissProt ID

    Q9H8H3

  • Synonyms

    AAM-B

METTL7A Antibody (YA8008)(PBS only) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • METTL7A Antibody (YA8008)(PBS only) Product Image