TUBA1A Antibody (YA8250)
(Synonyms: B-ALPHA-1; LIS3; TUBA3)TUBA1A Antibody (YA8250) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TUBA1A.
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Host:
Mouse
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Isotype:
IgG
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Application:
IHC-P
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Reactivity :
Human, Dog, Rat, Monkey, Mouse
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
TUBA1A Antibody (YA8250) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TUBA1A.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Dog, Rat, Monkey, Mouse
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Calculated Molecular Weight Predicted band size: 50 kDa
Full length human recombinant protein of human TUBA1A produced in HEK293T cell
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
TUBA1A is a Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin
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Subcellular Localization
Cytoplasm, cytoskeleton,Cytoplasm, cytoskeleton, flagellum axoneme
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Expression
Tissue_Specificity: Expressed at a high level in fetal brain -
Isoforms & Post-Translational Modification
Q71U36 has two isomers: Q71U36-1: 50136 Da (predicted); Q71U36-2: 46297 Da (predicted).
Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866)丨Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human丨Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen丨Methylation of alpha chains at Lys-40 is found in mitotic microtubules and is required for normal mitosis and cytokinesis contributing to genomic stability丨Nitration of Tyr-451 is irreversible and interferes with normal dynein intracellular distribution丨Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (MATCAP1/KIAA0895L, VASH1 or VASH2) and tubulin tyrosine ligase (TTL), respectively丨Tyrosination promotes microtubule interaction with CAP-Gly domain-containing proteins such as CLIP1, CLIP2 and DCTN1丨Detyrosination is involved in metaphase plate congression by guiding chromosomes during mitosis: detyrosination promotes interaction with CENPE, promoting pole-proximal transport of chromosomes toward the equator (PubMed:25908662) -
Subunit
Dimer of alpha and beta chains
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SwissProt ID
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Synonyms
B-ALPHA-1; LIS3; TUBA3
Documentation
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