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VDAC1/2/3 direct binder

" in MedChemExpress (MCE) Product Catalog:

861

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13

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76

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45

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42

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9

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61

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73

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5

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63

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5

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8

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1

GMP Molecules

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-129122
    VBIT-4
    15+ Cited Publications

    		 VDAC Cardiovascular Disease Neurological Disease
    VBIT-4 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 17 μM. VBIT-4, as an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders, such as neurodegenerative and cardiovascular diseases [1].
    VBIT-4
  • HY-D0086
    DIDS sodium salt
    20+ Cited Publications

    MDL101114ZA

    		 VDAC RAD51 Cancer
    DIDS sodium salt (MDL101114ZA) is a dual inhibitor of ABCA1 and VDAC1. DIDS also inhibits RAD51, inhibiting RAD51-mediated homologous pairing and strand exchange reactions. DIDS inhibits anion exchange and binding to red blood cell membranes, inhibits the activation of caspase-3 and -9, and can be used in cancer research [1] .
    DIDS sodium salt
  • HY-N1428C
    Ferric citrate
    5 Publications Verification

    Iron(III) citrate; Zerenex

    		 Reactive Oxygen Species (ROS) Antibiotic Metabolic Disease
    Ferric citrate (Iron(III) citrate), an orally active iron supplement, is an efficacious phosphate binder. Ferric citratee can be used for iron deficiency anemia and chronic kidney disease (CKD) research [1] .
    Ferric citrate
  • HY-135885
    VBIT-12
    5+ Cited Publications

    		 VDAC Neurological Disease
    VBIT-12 is a potent VDAC1 inhibitor. VBIT-12 directly interacts with VDAC1 and prevents VDAC1 oligomerization, and thus inhibits apoptotic action of VDAC1 [1].
    VBIT-12
  • HY-D0333
    Direct Red 80
    2 Publications Verification

    Sirius Red

    		 Amyloid-β Others
    Direct Red 80 (Sirius Red) is a polyazo dye used principally in staining methods for collagen and amyloid. Direct Red 80 does not release benzidine upon degradation and is safer than many traditional direct dyes [1].
    Direct Red 80
  • HY-153910
    AGPS-IN-1

    		Others Cancer
    AGPS-IN-1 (Compound 2i) is an effective AGPS binder. AGPS-IN-1 reduces ether lipids levels and cell migration rate. AGPS-IN-1 inhibits epithelial-mesenchymal transition (EMT) in prostate PC-3 and breast MDA-MB-231 cancer cells [1].
    AGPS-IN-1
  • HY-108937
    NSC 15364
    5+ Cited Publications

    		 VDAC Apoptosis Cardiovascular Disease Neurological Disease
    NSC 15364 is an inhibitor of VDAC1 oligomerization and apoptosis [1].
    NSC 15364
  • HY-160116
    α-Synuclein aggregate binder 1

    		Radionuclide-Drug Conjugates (RDCs) Fluorescent Dye α-synuclein Neurological Disease
    α-Synuclein aggregate binder 1 (Compound C05-05) is a specific binder for α-synuclein aggregates and can inhibit α-synuclein aggregation. α-Synuclein aggregate binder 1 can be used as a fluorescent probe (excitation wavelength 900 nm, detection wavelength 500-550 nm) for optical imaging, and can also inhibit α-synuclein fibril formation by blocking the aggregation process. α-Synuclein aggregate binder 1 can be used for positron emission tomography (PET) imaging after being labeled with 18F. α-Synuclein aggregate binder 1 can be used for visual diagnosis of brain lesions and mechanism research of neurodegenerative diseases such as Parkinson's disease and Lewy body dementia [1] .
    α-Synuclein aggregate binder 1
  • HY-D0256
    Direct Black 38
    2 Publications Verification

    Chlorazol Black E; Ferristatin II disodium; C.I. 30235

    		 Biochemical Assay Reagents Others
    Direct Black 38 (Chlorazol Black E) is a benzidine-based azo dye, a substrate of Enterococcus gallinarum, and is mainly used for textile dyeing. Direct Black 38 is biodegradable after being reduced by microbial enzymes (such as Enterococcus gallinarum azoreductase), breaking the azo bonds and releasing benzidine and 4-aminobiphenyl. Direct Black 38 can be used in environmental toxicology, wastewater treatment and carcinogenicity studies, but its metabolite benzidine is listed as a human carcinogen [1].
    Direct Black 38
  • HY-D0939
    Direct Blue 1
    2 Publications Verification

    Chicago Sky Blue 6B

    		 Amyloid-β NF-κB Inflammation/Immunology
    Direct Blue 1 (Chicago Sky Blue 6B) is a complex dye for background autofluorescence in immunofluorescence histochemistry. Direct Blue 1 is a potent and competitive VGLUT inhibitor. Direct Blue 1 can inhibit the Aβ-binding small molecule PrP ligand. Direct Blue 1 has anti-inflammatory activity [1] .
    Direct Blue 1
  • HY-B1787
    Sulindac sulfone

    		mTOR Drug Metabolite CDK PPAR Apoptosis Cancer
    Sulindac sulfone is an orally active metabolite of Sulindac (HY-B0008). Sulindac sulfone activates PPARγ and drives transcriptional induction of SSAT by binding to the PPRE-2 element. Sulindac sulfone induces Apoptosis. Sulindac sulfone negatively regulates the function of VDAC1/2 to inhibit the mTORC1 pathway, reduces Cyclin D1 levels, and induces G1 cell cycle arrest in colon cancer cells. Sulindac sulfone exerts colon cancer preventive effects through a COX-independent mechanism. Sulindac sulfone can be used in research related to colon cancer [1] .
    Sulindac sulfone
  • HY-D0953
    Direct Blue 86

    Solvent Blue 38

    		 Environmental Pollutants Fluorescent Dye Neurological Disease
    Direct Blue 86 (Solvent Blue 38) is a myelin-sheath stain, commonly utilized in microscopy to detect demyelination in the central nervous system. Direct Blue 86 also is a dye with various applications including as a commercial dye in the printing of cotton and mucilage glue fabrics [1].
    Direct Blue 86
  • HY-112939
    Colestilan

    MCI-196; Colestimide

    		 Biochemical Assay Reagents Metabolic Disease
    Colestilan (MCI-196) is a non-absorbed, non-calcium-based phosphate binder and is also a non-metallic, anion exchange resin. Colestilan is orally active and can be used for hypercholesterolaemia research [1] .
    Colestilan
  • HY-121693
    DIDS

    MDL101114ZA free base

    		 VDAC RAD51 Cancer
    DIDS is a dual inhibitor of ABCA1 and VDAC1. DIDS also inhibits RAD51, inhibiting RAD51-mediated homologous pairing and strand exchange reactions. DIDS inhibits anion exchange and binding to red blood cell membranes, inhibits the activation of caspase-3 and -9, and can be used in cancer research [1] .
    DIDS
  • HY-116785
    BRD32048

    		DNA/RNA Synthesis Cancer
    BRD32048 is a direct binder of ETV1 with a KD of 17.1 μM. BRD32048 modulates both ETV1-mediated transcriptional activity and invasion of ETV1-driven cancer cells. BRD32048 inhibits ETV1 acetylation and promotes its degradation. BRD32048 acts as a top candidate ETV1 perturbagen [1].
    BRD32048
  • HY-149934
    DCAF1 binder 1

    		Ligands for E3 Ligase Cancer
    DCAF1 binder 1 is a selective for the CRL4 DCAF1 E3 ligase complex. DCAF1 binder 1 is a ligands for E3 Ligase, involving in targeted protein degradation (TPD) [1].
    DCAF1 binder 1
  • HY-158123
    PSMA binder-1

    		PSMA Cancer
    PSMA binder-1 is a ligand for PSMA and can be used to synthesize PSMA targeting molecule, such as Ac-PSMA-trillium [1] .
    PSMA binder-1
  • HY-146186
    JAK2 JH2 binder-1

    		JAK Cancer
    JAK2 JH2 binder-1 (compound 11) is a potent and selective JAK2 JH2 binder, with a Kd of 37.1 nM. JAK2 JH2 binder-1 has the potential for various myeloproliferative neoplasms research [1].
    JAK2 JH2 binder-1
  • HY-126302
    DMT1 blocker 2
    3 Publications Verification

    		 Ferroportin Metabolic Disease
    DMT1 blocker 2 is a direct inhibitor of divalent metal transporter 1 (DMT1), with an IC50 of 0.83 μM. DMT1 blocker 2 can block iron uptake by enterocytes in vivo [1].
    DMT1 blocker 2
  • HY-RS16872
    Vdac1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Vdac1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Vdac1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Vdac1 Mouse Pre-designed siRNA Set A
    Vdac1 Mouse Pre-designed siRNA Set A
  • HY-111217
    AKOS-22

    		VDAC Mitochondrial Metabolism Neurological Disease Cancer
    AKOS-22 is a potent mitochondrial protein VDAC1 (voltage-dependent anion channel 1) inhibitor (Kd=15.4 μM). AKOS-22 interacts with VDAC1 and inhibiting both VDAC1 oligomerization and apoptosis. AKOS-22 protects against mitochondrial dysfunction [1].
    AKOS-22
  • HY-D1196
    Direct Blue 71

    		Fluorescent Dye
    Direct Blue 71 is a good dyeing agent for cotton fabrics and can be adsorbed by palm ash and removed from the aqueous solution.
    Direct Blue 71
  • HY-148433
    SpdSyn binder-1

    		Parasite Infection Inflammation/Immunology
    SpdSyn binder-1 is a weak binder, which binds in the active site of plasmodium falciparum spermidine synthase. SpdSyn binder-1 can be used for the research of malaria [1].
    SpdSyn binder-1
  • HY-D0245
    Direct Red 23

    		Fluorescent Dye
    Direct Red 23 is a good dyeing agent for cotton fabrics.
    Direct Red 23
  • HY-156215
    NCI-B16

    		HCV Infection
    NCI-B16 is a small molecule RNA binder and inhibits HCV viral replication [1].
    NCI-B16
  • HY-161027
    2,6-Didehydropeperomin B

    		Carnitine Palmitoyltransferase (CPT) Apoptosis Cancer
    DHP-B is an Ecolignan-type compound and covalent, selective CPT1A inhibitor with a Kd of 1.62 μM. DHP-B can be isolated from the plant Peperomia dindygulensis. DHP-B covalently binds to Cys96 of CPT1A, blocks FAO, and disrupts the mitochondrial CPT1A-VDAC1 interaction. DHP-B triggers Apoptosis. DHP-B exhibits anti-CRC activity [1].
    2,6-Didehydropeperomin B
  • HY-141536
    PSMA-ALB-56

    		Drug-Linker Conjugates for ADC Cancer
    PSMA-ALB-56 is a PSMA-targeting radioligand designed by combining the glutamate-urea PSMA-binding entity and an albumin binder [1].
    PSMA-ALB-56
  • HY-10515
    BX-320

    		PDK-1 Cancer
    BX-320 is a selective, ATP-competitive, orally acitive, and direct PDK1 inhibitor with an IC50 of 30 nM in a direct kinase assay format. BX-320 also induces apoptosis. Anticancer effect [1].
    BX-320
  • HY-D0563
    Direct yellow 86

    		Fluorescent Dye Others
    Direct yellow 86 is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
    Direct yellow 86
  • HY-176745
    SW016789

    		VDAC Metabolic Disease Endocrinology
    SW016789 is a hypersecretion-inducer targeting VDAC1. SW016789 can induce insulin hypersecretion and Ca 2+ influx in β-cells directly. SW016789 induces a transient endoplasmic reticulum stress response (ER stress), but does not cause beta cell death. SW016789 has reversible and non-apoptotic characteristics. SW016789 can be used for the study of Diabetes mellitus type 2 (T2DM) β-cell dysfunction [1] .
    SW016789
  • HY-RS15629
    VDAC1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    VDAC1 Human Pre-designed siRNA Set A contains three designed siRNAs for VDAC1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    VDAC1 Human Pre-designed siRNA Set A
    VDAC1 Human Pre-designed siRNA Set A
  • HY-159758
    EcDHFR/FKBP12 F36V binder-1

    		Others Neurological Disease Cancer
    EcDHFR/FKBP12 F36V binder-1 (compound 1) is a bifunctional molecule that combines the Escherichia coli dihydrofolate reductase domain (EcDHFR) with the FKBP12 F36V domain [1].
    EcDHFR/FKBP12 F36V binder-1
  • HY-D0350
    Direct Yellow 50

    		Environmental Pollutants Fluorescent Dye Others
    Direct Yellow 50 is a good dyeing agent for cotton fabrics.
    Direct Yellow 50
  • HY-D1270
    Direct Violet 1

    		SARS-CoV Infection
    Direct Violet 1, an azo dye, is a textile dye. Direct Violet 1 is also the protein-protein interaction (PPI) between the SARS-CoV-2 spike protein and ACE2 inhibitor with IC50s of 1.47-2.63 μM [1] .
    Direct Violet 1
  • HY-152242
    YEATS4-IN-1

    PFI-8

    		 Histone Methyltransferase Others
    YEATS4-IN-1 (Compound 4d) is a potent and selective YEATS4 binder that binds to the KAc recognition site of the YEATS structural domain with a Ki value of 33 nM [1].
    YEATS4-IN-1
  • HY-RS23313
    Vdac1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Vdac1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Vdac1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Vdac1 Rat Pre-designed siRNA Set A
    Vdac1 Rat Pre-designed siRNA Set A
  • HY-158125
    PSMA binder-2

    		PSMA Cancer
    PSMA binder-2 is a ligand for PSMA and can be used to synthesize Ac-PSMA-trillium. Ac-PSMA-trillium is a suitable PSMA-targeting compound with improved PSMA binding properties and pharmacokinetic properties. PSMA ligands have different biological applications after being modified with different radioactive isotopes. If labeled with 111In, it can be used as DOTA chelating agent and imaging agent. Or labeled with 225Ac as a Macropa chelator for targeted radionuclide therapy (TRT) in the study of metastatic castration-resistant prostate cancer (mCRPC) [1] .
    PSMA binder-2
  • HY-D0404
    Direct red 254

    		Fluorescent Dye Neurological Disease
    Direct Red 254 is a bisazo dye for textile applications. Direct Red 254 can be used for amyloid tissue staining in basic research on neurodegenerative diseases (e.g., Alzheimer's disease) [1] .
    Direct red 254
  • HY-W127722
    Direct Red 75 tetrasodium

    		Biochemical Assay Reagents Others
    Direct Red 75 tetrasodium salt is an azo dye.
    Direct Red 75 tetrasodium
  • HY-D2253
    Direct Blue 108

    		Fluorescent Dye Others
    Direct Blue 108 has the structure of triphenyl two oxazine, and can be used in dyeing of cotton, viscose fiber, silk and its blended fabrics [1].
    Direct Blue 108
  • HY-135571
    VBIT-3

    		VDAC Cardiovascular Disease Neurological Disease
    VBIT-3 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 31.3 μM. VBIT-3, as an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders, such as neurodegenerative and cardiovascular diseases [1].
    VBIT-3
  • HY-161626
    PSMA binder-3

    		PSMA Cancer
    PSMA binder-3 is a binder of PSMA.
    PSMA binder-3
  • HY-174226
    RNA binder 2

    		DNA/RNA Synthesis Others
    RNA binder 2 (Compound 20) is a covalent inhibitor targeting the r(CUG)exp RNA in myotonic dystrophy type 1 (DM1). RNA binder 2 binds to RNA via a Hoechst scaffold, blocking MBNL1 binding and restoring normal splicing. RNA binder 2 is promising for research of DM1 [1].
    RNA binder 2
  • HY-176925
    α-Synuclein aggregate binder 2

    		α-synuclein Amyloid-β Neurological Disease
    α-Synuclein aggregate binder 2 (Compound 1) is a specific alpha-synuclein binder with a Ki of 1.6 nM. α-Synuclein aggregate binder 2 has a weak binding affinity for β-amyloid aggregates with a Ki of 295 nM. α-Synuclein aggregate binder 2 can be used as a tracer in Parkinson's disease [1].
    α-Synuclein aggregate binder 2
  • HY-156743
    DCAF1 binder 2

    		Others Others
    DCAF1 binder 2, a ligands for E3 Ligase, involves in BRD9, kinase and selective BTK degration.
    DCAF1 binder 2
  • HY-D0334
    Direct Red 81

    		Fluorescent Dye
    Direct Red 81 is a diazo dye with a very high water solubility. The dye adsorption efficiency of Direct Red 81 is increased by increasing the adsorbent dose and adsorption time [1].
    Direct Red 81
  • HY-D0518
    Direct red 227

    		Fluorescent Dye
    Direct red 227 is a good dyeing agent for cotton fabrics.
    Direct red 227
  • HY-D0539
    Direct red 239

    		Fluorescent Dye Others
    Direct red 239 is a good dyeing agent for cotton fabrics.
    Direct red 239
  • HY-D1183
    Direct blue 67

    		Fluorescent Dye
    Direct blue 67 is a good dyeing agent for cotton fabrics.
    Direct blue 67
  • HY-D1207
    Direct Orange 26

    		Fluorescent Dye
    Direct Orange 26 is a good dyeing agent for cotton fabrics.
    Direct Orange 26

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