Linvoseltamab
Based on 1 Customer Validation
Linvoseltamab (REGN5458) is a bispecific T-cell engager (BiTE) antibody that specifically binds to B cell maturation antigen (BCMA) and CD3 of T cells, thereby directing T cells to multiple myeloma (MM) cells expressing BCMA and activating T cells to kill tumor cells. Linvoseltamab can be used in research of relapsed/refractory multiple myeloma (RRMM).
For research use only. We do not sell to patients.
- Purity: 99.71%
- CAS No.: 2408319-25-3
- Molecular Weight:145.51 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Human IgG4 kappa
Human
CD3E & TNFRSF17
Linvoseltamab (0.1-10 nM, 48 h) activates NFAT signaling in effector cells, increases the expression of T-cell activation marker CD25, and induces cytotoxicity in BCMA-expressing human plasma cells and multiple myeloma (MM) cells, such as NCI-H929 and MOLP-8[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NCI-H929 and MOLP-8
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Concentration:0.1-10 nM
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Incubation Time:48 h
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Result:Inhibited cell viability of NCI-H929 and MOLP-8.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NCI-H929 or MOLP-8 xenograft mouse models[3]
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Dosage:0.4-4 mg/kg
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Administration:iv, twice a week for 7 doses
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Result:Inhibited growth of tumor volume.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG4 kappa
ELISA, FACS, Functional assay
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Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Linvoseltamab (HY-P9989). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa Isotype Control (HY-P99003, blue) was used as the isotype control.
Chemical Information
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CAS No. 2408319-25-3
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Appearance Liquid
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Molecular Weight 145.51 kDa
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Color Colorless to light yellow
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SMILES
[Linvoseltamab]
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Synonyms
REGN5458
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)