Carboxy-PTIO potassium

Name: Carboxy-PTIO potassium
Brand: MedChemExpress
SKU: HY-18734A
Rating: 4.5 (3 reviews)

Cat. No.: HY-18734A Purity: 99.02%: FAQs
Data Sheet SDS COA Handling Instructions

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Carboxy-PTIO potassium is a potent nitric oxide (NO) scavenger that can make a quick reaction with NO to produce NO₂. Carboxy-PTIO potassium can prevent hypotension and endotoxic shock through the direct scavenging action against NO in lipopolysaccharide-stimulated rat model.

For research use only. We do not sell to patients.

Carboxy-PTIO potassium Chemical Structure

CAS No. : 148819-94-7

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5 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
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Based on 3 publication(s) in Google Scholar

Other Forms of Carboxy-PTIO potassium:

Carboxy-PTIO Get quote

3 Publications Citing Use of MCE Carboxy-PTIO potassium

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Carboxy-PTIO potassium (200 μM; 1 h prior to physalin A; 24 hours) significantly suppresses the stimulation of NO expression induced by Physalin A (HY-N9942) treatment, but no change is observed in Carboxy-PTIO treatment alone^[1].
Carboxy-PTIO potassium (200 μM; 1 h prior to physalin A; 24 hours) reduces Physalin A-induced cleavage of procaspase-3 and PARP, down-regulated ICAD expression,diminishing DNA fragmentation in nuclei^[1].
Carboxy-PTIO potassium (200 μM; 1 h prior to Physalin A; 24 hours) shows no effect on iNOS expression. However, decreased-mTOR and p-mTOR levels induced by Physalin A is reversed by Carboxy-PTIO with concomitant suppression of LC3 I to LC3 II conversions in A375-S2 cells ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	A375-S2 cells
Concentration:	200 μM
Incubation Time:	1 h prior to physalin A; 24 hours
Result:	Diminished physalin A-induced procaspase-3 and PARP cleavage.

In Vivo

Carboxy-PTIO (intravenous?injection; 0.056-1.70 mg/kg/min; infused for 1 hr beginning 90 min after the LPS injection 90 min) treatment improves the hypotension, renal dysfunction and survival rate in Lps-treated rats. But it does not affect each parameter in normal rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	SD rats^[3]
Dosage:	0.056-1.70 mg/kg/min
Administration:	Intravenous injection; 0.056-1.70 mg/kg/min; infused for 1 hr beginning 90 min after the LPS injection 90 min
Result:	Exhibited a potent therapeutic value in endotoxin shock through the direct scavenging action against NO.

Molecular Weight

315.39

Formula

C₁₄H₁₆KN₂O₄

CAS No.

148819-94-7

Appearance

Solid

Color

Brown to black

SMILES

[O]N1C(C)(C)C(C)(C)[N+]([O-])=C1C2=CC=C(C(O[K])=O)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 25 mg/mL (79.27 mM; ultrasonic and warming and heat to 60°C)

DMSO : 10 mg/mL (31.71 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1707 mL	15.8534 mL	31.7068 mL
5 mM	0.6341 mL	3.1707 mL	6.3414 mL
10 mM	0.3171 mL	1.5853 mL	3.1707 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (158.53 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.02%

Select Batch:

Data Sheet (278 KB) SDS (393 KB)

COA (252 KB) RP-HPLC (278 KB) MS (181 KB)

Handling Instructions (2659 KB)

References

[1]. Hao He, et al.Nitric oxide induces apoptosis and autophagy; autophagy down-regulates NO synthesis in physalin A-treated A375-S2 human melanoma cells.Food Chem Toxicol. 2014 Sep;71:128-35. [Content Brief]

[2]. T Akaike, et al. Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.NO through a radical reaction. Biochemistry. 1993 Jan 26;32(3):827-32. [Content Brief]

[3]. M Yoshid, et al. Therapeutic effects of imidazolineoxyl N-oxide against endotoxin shock through its direct nitric oxide-scavenging activity. Biochem Biophys Res Commun. 1994 Jul 29;202(2):923-30. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	3.1707 mL	15.8534 mL	31.7068 mL	79.2669 mL
	5 mM	0.6341 mL	3.1707 mL	6.3414 mL	15.8534 mL
	10 mM	0.3171 mL	1.5853 mL	3.1707 mL	7.9267 mL
	15 mM	0.2114 mL	1.0569 mL	2.1138 mL	5.2845 mL
	20 mM	0.1585 mL	0.7927 mL	1.5853 mL	3.9633 mL
	25 mM	0.1268 mL	0.6341 mL	1.2683 mL	3.1707 mL
	30 mM	0.1057 mL	0.5284 mL	1.0569 mL	2.6422 mL
H₂O	40 mM	0.0793 mL	0.3963 mL	0.7927 mL	1.9817 mL
	50 mM	0.0634 mL	0.3171 mL	0.6341 mL	1.5853 mL
	60 mM	0.0528 mL	0.2642 mL	0.5284 mL	1.3211 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.