1. Immunology/Inflammation
  2. NO Synthase
  3. Carboxy-PTIO potassium

Carboxy-PTIO potassium 

Cat. No.: HY-18734A Purity: 99.02%
COA Handling Instructions

Carboxy-PTIO potassium is a potent nitric oxide (NO) scavenger that can make a quick reaction with NO to produce NO2. Carboxy-PTIO potassium can prevent hypotension and endotoxic shock through the direct scavenging action against NO in lipopolysaccharide-stimulated rat model.

For research use only. We do not sell to patients.

Carboxy-PTIO potassium Chemical Structure

Carboxy-PTIO potassium Chemical Structure

CAS No. : 148819-94-7

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5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 160 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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1 Publications Citing Use of MCE Carboxy-PTIO potassium

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Description

Carboxy-PTIO potassium is a potent nitric oxide (NO) scavenger that can make a quick reaction with NO to produce NO2. Carboxy-PTIO potassium can prevent hypotension and endotoxic shock through the direct scavenging action against NO in lipopolysaccharide-stimulated rat model[1][2][3].

In Vitro

Carboxy-PTIO potassium (200 μM; 1 h prior to physalin A; 24 hours) significantly suppresses the stimulation of NO expression induced by physalin A treatment, but no change is observed in Carboxy-PTIO treatment alone[1].
Carboxy-PTIO potassium (200 μM; 1 h prior to physalin A; 24 hours) reduces physalin A-induced cleavage of procaspase-3 and PARP, down-regulated ICAD expression,diminishing DNA fragmentation in nuclei[1].
Carboxy-PTIO potassium (200 μM; 1 h prior to physalin A; 24 hours) shows no effect on iNOS expression. However, decreased-mTOR and p-mTOR levels induced by physalin A is reversed by Carboxy-PTIO with concomitant suppression of LC3 I to LC3 II conversions in A375-S2 cells [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: A375-S2 cells
Concentration: 200 μM
Incubation Time: 1 h prior to physalin A; 24 hours
Result: Diminished physalin A-induced procaspase-3 and PARP cleavage.
In Vivo

Carboxy-PTIO (intravenous injection; 0.056-1.70 mg/kg/min; infused for 1 hr beginning 90 min after the LPS injection 90 min) treatment improves the hypotension, renal dysfunction and survival rate in Lps-treated rats. But it does not affect each parameter in naomal rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SD rats[3]
Dosage: 0.056-1.70 mg/kg/min
Administration: Intravenous injection; 0.056-1.70 mg/kg/min; infused for 1 hr beginning 90 min after the LPS injection 90 min
Result: Exhibited a potent therapeutic value in endotoxin shock through the direct scavenging action against NO.
Molecular Weight

315.39

Formula

C14H16KN2O4

CAS No.
SMILES

[O]N1C(C)(C)C(C)(C)[N+]([O-])=C1C2=CC=C(C(O[K])=O)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (79.27 mM; ultrasonic and warming and heat to 60°C)

DMSO : 10 mg/mL (31.71 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1707 mL 15.8534 mL 31.7068 mL
5 mM 0.6341 mL 3.1707 mL 6.3414 mL
10 mM 0.3171 mL 1.5853 mL 3.1707 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 99.02%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Carboxy-PTIO potassium
Cat. No.:
HY-18734A
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