1. Immunology/Inflammation
  2. NO Synthase
  3. Carboxy-PTIO potassium

Carboxy-PTIO potassium 

Cat. No.: HY-18734A
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Carboxy-PTIO potassium is a potent nitric oxide (NO) inhibitor that can make a quick reaction with NO to produce NO2. Carboxy-PTIO can prevent hypotension and endotoxic shock through the direct scavenging action against NO in lipopolysaccharide-stimulated rat model.

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Carboxy-PTIO potassium Chemical Structure

Carboxy-PTIO potassium Chemical Structure

CAS No. : 148819-94-7

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Description

Carboxy-PTIO potassium is a potent nitric oxide (NO) inhibitor that can make a quick reaction with NO to produce NO2. Carboxy-PTIO can prevent hypotension and endotoxic shock through the direct scavenging action against NO in lipopolysaccharide-stimulated rat model[1][2][3].

In Vitro

Carboxy-PTIO potassium (200 μM; 1 h prior to physalin A; 24 hours) significantly suppresses the stimulation of NO expression induced by physalin A treatment, but no change is observed in Carboxy-PTIO treatment alone[1].
Carboxy-PTIO potassium (200 μM; 1 h prior to physalin A; 24 hours) reduces physalin A-induced cleavage of procaspase-3 and PARP, down-regulated ICAD expression,diminishing DNA fragmentation in nuclei[1].
Carboxy-PTIO potassium (200 μM; 1 h prior to physalin A; 24 hours) shows no effect on iNOS expression. However, decreased-mTOR and p-mTOR levels induced by physalin A is reversed by Carboxy-PTIO with concomitant suppression of LC3 I to LC3 II conversions in A375-S2 cells [1].

Western Blot Analysis[1]

Cell Line: A375-S2 cells
Concentration: 200 μM
Incubation Time: 1 h prior to physalin A; 24 hours
Result: Diminished physalin A-induced procaspase-3 and PARP cleavage.
In Vivo

Carboxy-PTIO (intravenous injection; 0.056-1.70 mg/kg/min; infused for 1 hr beginning 90 min after the LPS injection 90 min) treatment improves the hypotension, renal dysfunction and survival rate in Lps-treated rats. But it does not affect each parameter in naomal rats[3].

Animal Model: SD rats[3]
Dosage: 0.056-1.70 mg/kg/min
Administration: Intravenous injection; 0.056-1.70 mg/kg/min; infused for 1 hr beginning 90 min after the LPS injection 90 min
Result: Exhibited a potent therapeutic value in endotoxin shock through the direct scavenging action against NO.
Molecular Weight

315.39

Formula

C₁₄H₁₆KN₂O₄

CAS No.

148819-94-7

SMILES

[O]N1C(C)(C)C(C)(C)[N+]([O-])=C1C2=CC=C(C(O[K])=O)C=C2

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Keywords:

Carboxy-PTIONO SynthaseNitric oxide synthasesNOSNO synthaseNO scavengehypotensionendotoxic shockiNOSrenal dysfunctionInhibitorinhibitorinhibit

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Carboxy-PTIO potassium
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