Carboxy-PTIO
Based on 7 publication(s) in Google Scholar
Carboxy-PTIO is a potent nitric oxide (NO) scavenger that can make a quick reaction with NO to produce NO2. Carboxy-PTIO can prevent hypotension and endotoxic shock through the direct scavenging action against NO in lipopolysaccharide-stimulated rat model.
For research use only. We do not sell to patients.
- CAS No.: 145757-47-7
- Formula: C14H17N2O4
- Molecular Weight:277.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Carboxy-PTIO
More- Antioxid Redox Signal. 2023 Apr;38(10-12):747-767. [Abstract]
- Neurosci Bull. 2025 Jun 28. [Abstract]
- Int Immunopharmacol. 2025 Dec 24:170:116055. [Abstract]
- iScience. 2023 Jul 10;26(8):107353. [Abstract]
- Toxicol Appl Pharmacol. 2024 May 20:487:116976. [Abstract]
- Int J Radiat Biol. 2025 Feb 3:1-10. [Abstract]
- Pharmacological Research-Modern Chinese Medicine. 2024 Mar, 10, 100365.
Biological Activity
Carboxy-PTIO (200 μM; 1 h prior to physalin A; 24 hours) significantly suppresses the stimulation of NO expression induced by physalin A treatment, but no change is observed in Carboxy-PTIO treatment alone[1]. Carboxy-PTIO (200 μM; 1 h prior to physalin A; 24 hours) reduces physalin A-induced cleavage of procaspase-3 and PARP, down-regulated ICAD expression,diminishing DNA fragmentation in nuclei[1]. Carboxy-PTIO (200 μM; 1 h prior to physalin A; 24 hours) shows no effect on iNOS expression. However, decreased-mTOR and p-mTOR levels induced by physalin A is reversed by Carboxy-PTIO with concomitant suppression of LC3 I to LC3 II conversions in A375-S2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A375-S2 cells
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Concentration:200 μM
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Incubation Time:1 h prior to physalin A; 24 hours
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Result:Diminished physalin A-induced procaspase-3 and PARP cleavage.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SD rats[3]
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Dosage:0.056-1.70 mg/kg/min
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Administration:Intravenous injection; 0.056-1.70 mg/kg/min; infused for 1 hr beginning 90 min after the LPS injection 90 min
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Result:Exhibited a potent therapeutic value in endotoxin shock through the direct scavenging action against NO.
Chemical Information
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CAS No. 145757-47-7
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Molecular Weight 277.30
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Formula C14H17N2O4
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SMILES
[O]N1C(C)(C)C(C)(C)[N+]([O-])=C1C2=CC=C(C(O)=O)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (7)
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Journal Impact Factor
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Most Recent
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Antioxid Redox Signal
Radiation-induced bystander effect on the genome of bone marrow mesenchymal stem cells in lung cancer. [Abstract]2023 Apr;38(10-12):747-767. PMID: 36242096 -
Neurosci Bull
2025 Jun 28. PMID: 40580390 -
Int Immunopharmacol
Targeting periodontal inflammatory microenvironment to ameliorate periodontitis: A nitrogen ions implantation technique. [Abstract]2025 Dec 24:170:116055. PMID: 41448003 -
iScience
2023 Jul 10;26(8):107353. PMID: 37529099 -
Toxicol Appl Pharmacol
RGS2 attenuates alveolar macrophage damage by inhibiting the Gq/11-Ca2+ pathway during cowshed PM2.5 exposure, and aberrant RGS2 expression is associated with TLR2/4 activation. [Abstract]2024 May 20:487:116976. PMID: 38777097 -
Int J Radiat Biol
Evaluation of the influence of radiation-induced cohort effect in cell populations receiving different doses. [Abstract]2025 Feb 3:1-10. PMID: 39899278 -
Purity & Documentation
References
[1]. Hao He, et al.Nitric oxide induces apoptosis and autophagy; autophagy down-regulates NO synthesis in physalin A-treated A375-S2 human melanoma cells.Food Chem Toxicol. 2014 Sep;71:128-35. [Content Brief]
[2]. T Akaike, et al. Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.NO through a radical reaction. Biochemistry. 1993 Jan 26;32(3):827-32. [Content Brief]
[3]. M Yoshid, et al. Therapeutic effects of imidazolineoxyl N-oxide against endotoxin shock through its direct nitric oxide-scavenging activity. Biochem Biophys Res Commun. 1994 Jul 29;202(2):923-30. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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