Nω-Propyl-L-arginine
Based on 1 publication(s) in Google Scholar
Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a Ki of 57 nM. Nω-Propyl-L-arginine displays a 149-fold selectivity for nNOS over endothelial NOS (eNOS).
For research use only. We do not sell to patients.
- Purity: 98.31%
- CAS No.: 137361-05-8
- Formula: C9H20N4O2
- Molecular Weight:216.28
-
Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
Immunology/Inflammation Compound Library
HY-L007
-
Anti-Aging Compound Library
HY-L034
-
Neuroprotective Compound Library
HY-L070
-
Angiogenesis-Related Compound Library
HY-L088
-
Mitochondrial Protection Compound Library
HY-L144
-
Metabolic Enzyme Compound Library
HY-L146
-
Membrane Protein-targeted Compound Library
HY-L149
-
Highly Selective Inhibitors Library
HY-L158
-
MCE Bioactive Compound Library
HY-L001V
-
High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) Nω-Propyl-L-arginine
More
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male NMRI mice (30-40 g) (phencyclidine-induced stimulation)[2]
-
Dosage:20 mg/kg
-
Administration:I.p.
-
Result:Markedly reduced the phencyclidineinduced disruption of prepulse inhibition and significantly reduced the phencyclidine-induced stimulation of locomotor activity.
Chemical Information
-
CAS No. 137361-05-8
-
Appearance Solid
-
Molecular Weight 216.28
-
Formula C9H20N4O2
-
Color White to yellow
-
SMILES
N=C(NCCC)NCCC[C@H](N)C(O)=O
-
Synonyms
N-omega-Propyl-L-arginine
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Cancer Metab
Hypoxia-induced NOS1 as a therapeutic target in hypercholesterolemia-related colorectal cancer. [Abstract]2024 May 17;12(1):14. PMID: 38755702
Solvent & Solubility
H2O : ≥ 100 mg/mL (462.36 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (270 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Zhang HQ, et al. Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine. J Med Chem. 1997 Nov 21;40(24):3869-70. [Content Brief]
[2]. Klamer D, et al. The neuronal selective nitric oxide synthase inhibitor, Nomega-propyl-L-arginine, blocks the effects of phencyclidine on prepulse inhibition and locomotor activity in mice. Eur J Pharmacol. 2004 Oct 25;503(1-3):103-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.6236 mL | 23.1182 mL | 46.2364 mL | 115.5909 mL |
| 5 mM | 0.9247 mL | 4.6236 mL | 9.2473 mL | 23.1182 mL | |
| 10 mM | 0.4624 mL | 2.3118 mL | 4.6236 mL | 11.5591 mL | |
| 15 mM | 0.3082 mL | 1.5412 mL | 3.0824 mL | 7.7061 mL | |
| 20 mM | 0.2312 mL | 1.1559 mL | 2.3118 mL | 5.7795 mL | |
| 25 mM | 0.1849 mL | 0.9247 mL | 1.8495 mL | 4.6236 mL | |
| 30 mM | 0.1541 mL | 0.7706 mL | 1.5412 mL | 3.8530 mL | |
| 40 mM | 0.1156 mL | 0.5780 mL | 1.1559 mL | 2.8898 mL | |
| 50 mM | 0.0925 mL | 0.4624 mL | 0.9247 mL | 2.3118 mL | |
| 60 mM | 0.0771 mL | 0.3853 mL | 0.7706 mL | 1.9265 mL | |
| 80 mM | 0.0578 mL | 0.2890 mL | 0.5780 mL | 1.4449 mL | |
| 100 mM | 0.0462 mL | 0.2312 mL | 0.4624 mL | 1.1559 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Nω-Propyl-L-arginine Related Classifications
HY-102062 Related Classifications
Powered by Bioz