1. Immunology/Inflammation
  2. NO Synthase

GW274150 

Cat. No.: HY-12119 Purity: 99.84% ee.: 99.40%
Handling Instructions

GW274150 is a novel arginine-competitive, NADPH-dependent iNOS inhibitor that has been identified from a series of acetamide amino acids that have a high selectivity for iNOS vs both eNOS (> 260-fold) and nNOS (> 219-fold) and high bioavailability (> 90%) after oral administration.

For research use only. We do not sell to patients.

GW274150 Chemical Structure

GW274150 Chemical Structure

CAS No. : 210354-22-6

Size Price Stock Quantity
10 mM * 1 mL in Water USD 434 In-stock
Estimated Time of Arrival: December 31
1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

GW274150 is a novel arginine-competitive, NADPH-dependent iNOS inhibitor that has been identified from a series of acetamide amino acids that have a high selectivity for iNOS vs both eNOS (> 260-fold) and nNOS (> 219-fold) and high bioavailability (> 90%) after oral administration. Target: iNOS in vivo: GW274150 demonstrates a narrow neuroprotective therapeutic window against the toxic actions of 6-OHDA. GW274150 administration leads to a dose-dependent decrease in the number of iNOS-positive cells in the SNc of the 6-OHDA-lesioned animals. The iNOS inhibitor GW274150 fails to produce long-term neuroprotection after its withdrawal in the 6-OHDA-lesioned rat. [1]

Clinical Trial
Solvent & Solubility
In Vitro: 

H2O : ≥ 62 mg/mL (282.72 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5600 mL 22.7998 mL 45.5996 mL
5 mM 0.9120 mL 4.5600 mL 9.1199 mL
10 mM 0.4560 mL 2.2800 mL 4.5600 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

219.30

Formula

C₈H₁₇N₃O₂S

CAS No.

210354-22-6

SMILES

N[[email protected]@H](CCSCCNC(C)=N)C(O)=O

Storage

4°C, stored under nitrogen

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.84% ee.: 99.40%

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Product Name:
GW274150
Cat. No.:
HY-12119
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GW274150

Cat. No.: HY-12119