2. Immunology/Inflammation
  3. NO Synthase
  4. GW274150 dihydrochloride

GW274150 (dihydrochloride) is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM). GW274150 (dihydrochloride) displays less potency for both humans or rats endothelial NOS (eNOS) and neuronal NOS (nNOS). GW274150 (dihydrochloride) exerts a protective role in an acute model of lung injury inflammation.

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GW274150 dihydrochloride Chemical Structure

GW274150 dihydrochloride Chemical Structure

CAS No. : 438542-17-7

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GW274150 dihydrochloride Related Antibodies

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Description

GW274150 (dihydrochloride) is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM). GW274150 (dihydrochloride) displays less potency for both humans or rats endothelial NOS (eNOS) and neuronal NOS (nNOS). GW274150 (dihydrochloride) exerts a protective role in an acute model of lung injury inflammation[1][2][3].

Molecular Weight

292.23

Formula

C8H19Cl2N3O2S
CAS No.
SMILES

OC([C@@H](N)CCSCCNC(C)=N)=O.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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GW274150 dihydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GW274150438542-17-7GW 274150GW-274150NO SynthaseNitric oxide synthasesNOSInhibitorinhibitorinhibit

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GW274150 dihydrochloride
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HY-12119B
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