1. Immunology/Inflammation
  2. NO Synthase
  3. 2-Thiouracil

2-Thiouracil (Synonyms: Thiouracil)

Cat. No.: HY-B0503 Purity: ≥98.0%
Handling Instructions

2-Thiouracil (Thiouracil) is an antithyroid compound. 2-Thiouracil can function as a highly specific melanoma seeker. 2-Thiouracil is a selective inhibitor of neuronal nitric oxide synthase (nNOS) with a Ki of 20 μM.

For research use only. We do not sell to patients.

2-Thiouracil Chemical Structure

2-Thiouracil Chemical Structure

CAS No. : 141-90-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 55 In-stock
Estimated Time of Arrival: December 31
Solid
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

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Description

2-Thiouracil (Thiouracil) is an antithyroid compound. 2-Thiouracil can function as a highly specific melanoma seeker. 2-Thiouracil is a selective inhibitor of neuronal nitric oxide synthase (nNOS) with a Ki of 20 μM[1][2].

IC50 & Target

Ki: 20 μM (nNOS)[1]

Molecular Weight

128.15

Formula

C4H4N2OS

CAS No.
SMILES

O=C(C=CN1)NC1=S

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (390.17 mM; Need ultrasonic)

H2O : 0.67 mg/mL (5.23 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.8034 mL 39.0168 mL 78.0336 mL
5 mM 1.5607 mL 7.8034 mL 15.6067 mL
10 mM 0.7803 mL 3.9017 mL 7.8034 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3.75 mg/mL (29.26 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3.75 mg/mL (29.26 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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Product Name:
2-Thiouracil
Cat. No.:
HY-B0503
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