2-Thiouracil (Synonyms: Thiouracil)

Cat. No.: HY-B0503 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

2-Thiouracil (Thiouracil) is an antithyroid compound. 2-Thiouracil can function as a highly specific melanoma seeker. 2-Thiouracil is a selective inhibitor of neuronal nitric oxide synthase (nNOS) with a K_i of 20 μM.

For research use only. We do not sell to patients.

2-Thiouracil Chemical Structure

CAS No. : 141-90-2

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Free Sample (0.1 - 0.5 mg)		Apply Now
Solution
10 mM * 1 mL in DMSO	USD 55	In-stock	Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL ready for reconstitution	USD 55	In-stock	Estimated Time of Arrival: December 31
Solid
500 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
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Purity & Documentation
References
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Description

IC₅₀ & Target

Ki: 20 μM (nNOS)^[1]

Molecular Weight

128.15

Appearance

Solid

Formula

C₄H₄N₂OS

CAS No.

141-90-2

SMILES

O=C(C=CN1)NC1=S

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (390.17 mM; Need ultrasonic)

H₂O : 0.67 mg/mL (5.23 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.8034 mL	39.0168 mL	78.0336 mL
5 mM	1.5607 mL	7.8034 mL	15.6067 mL
10 mM	0.7803 mL	3.9017 mL	7.8034 mL

*Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 3.75 mg/mL (29.26 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO 90% corn oil
Solubility: ≥ 3.75 mg/mL (29.26 mM); Clear solution

*All of the co-solvents are available by MCE.

Purity & Documentation

Purity: 99.87%

Select Batch:

Data Sheet (274 KB) SDS (418 KB)

COA (250 KB)

Handling Instructions (2659 KB)

References

[1]. Palumbo, A., et al. 2-thiouracil is a selective inhibitor of neuronal nitric oxide synthase antagonising tetrahydrobiopterin-dependent enzyme activation and dimerisation. FEBS Lett, 2000. 485(2-3): p. 109-12. [Content Brief]

[2]. Napolitano, A., et al., Mechanism of selective incorporation of the melanoma seeker 2-thiouracil into growing melanin. J Med Chem, 1996. 39(26): p. 5192-201. [Content Brief]

2-Thiouracil Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Keywords:

2-Thiouracil141-90-2ThiouracilNO SynthaseNitric oxide synthasesNOSantithyroidnNOSmelanomaseekergrowingmelaninInhibitorinhibitorinhibit

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