141-90-2
141-90-2
Chemical Structure
2-Thiouracil
Synonym(s): Thiouracil
- CAS. Nr.: 141-90-2
- Formula:C4H4N2OS
- Molecular Weight:128.16
IUPAC Name: 2-thioxo-2,3-dihydropyrimidin-4(1H)-one
InChIKey: ZEMGGZBWXRYJHK-UHFFFAOYSA-N
SMILES: O=C(C=CN1)NC1=S
Biological Activity: 2-Thiouracil (Thiouracil) is a selective neuronal nitric oxide synthase (nNOS) inhibitor with a Ki value of 20 μM. 2-Thiouracil antagonizes BH4-induced nNOS dimerization. 2-Thiouracil is also an antithyroid compound and a highly specific melanoma detector. 2-Thiouracil stimulates the growth of pea and corn root segments[1][2][3].
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2-Thiouracil | 99.91% | 2-Thiouracil (Thiouracil) is a selective neuronal nitric oxide synthase (nNOS) inhibitor with a Ki value of 20 μM. 2-Thiouracil antagonizes BH4-induced nNOS dimerization. 2-Thiouracil is also an antithyroid compound and a highly specific melanoma detector. 2-Thiouracil stimulates the growth of pea and corn root segments. | ||||||||||||||||||||
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2-Thiouracil-13C,15N2 | 2-Thiouracil-13C,15N2 is the 13C, 15N labeled 2-Thiouracil. 2-Thiouracil (Thiouracil) is an antithyroid compound. 2-Thiouracil can function as a highly specific melanoma seeker. 2-Thiouracil is a selective inhibitor of neuronal nitric oxide synthase (nNOS) with a Ki of 20 μM. | |||||||||||||||||||||
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References
- [1]. Palumbo, A., et al. 2-thiouracil is a selective inhibitor of neuronal nitric oxide synthase antagonising tetrahydrobiopterin-dependent enzyme activation and dimerisation. FEBS Lett, 2000. 485(2-3): p. 109-12. [Content Brief]
- [2]. Napolitano, A., et al., Mechanism of selective incorporation of the melanoma seeker 2-thiouracil into growing melanin. J Med Chem, 1996. 39(26): p. 5192-201. [Content Brief]
- [3]. Woodstock L, et al. The effect of 2-thiouracil on the growth of cells in the root. Annals of Botany, 1963, 27(3): 403-414.
Keywords
