4-Thiouracil
Based on 1 Customer Validation
4-Thiouracil is a thionucleobase with cytostatic properties. 4-Thiouracil can be used as biological photoprobes to detect RNA structures and nucleic acid-nucleic acid contacts. 4-Thiouracil can also act as a strong ultraviolet A (UVA) photosensitizer, providing a source of the reactive oxygen species of O2. 4-Thiouracil is promising for research of photocross linking, photodamage, as well as photodynamic therapy.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.71%
- CAS. Nr.: 591-28-6
- Formel: C4H4N2OS
- Molecular Weight:128.15
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Speicherung:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Chemical Information
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CAS. Nr. 591-28-6
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Appearance Solid
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Molecular Weight 128.15
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Formel C4H4N2OS
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Color Light yellow to yellow
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SMILES
O=C(N1)NC=CC1=S
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Lösungsmittel & Löslichkeit
DMSO : 50 mg/mL (390.17 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 5 mg/mL (39.02 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 7.8034 mL | 39.0168 mL | 78.0336 mL | 195.0839 mL |
| 5 mM | 1.5607 mL | 7.8034 mL | 15.6067 mL | 39.0168 mL | |
| 10 mM | 0.7803 mL | 3.9017 mL | 7.8034 mL | 19.5084 mL | |
| 15 mM | 0.5202 mL | 2.6011 mL | 5.2022 mL | 13.0056 mL | |
| 20 mM | 0.3902 mL | 1.9508 mL | 3.9017 mL | 9.7542 mL | |
| 25 mM | 0.3121 mL | 1.5607 mL | 3.1213 mL | 7.8034 mL | |
| 30 mM | 0.2601 mL | 1.3006 mL | 2.6011 mL | 6.5028 mL | |
| 40 mM | 0.1951 mL | 0.9754 mL | 1.9508 mL | 4.8771 mL | |
| 50 mM | 0.1561 mL | 0.7803 mL | 1.5607 mL | 3.9017 mL | |
| 60 mM | 0.1301 mL | 0.6503 mL | 1.3006 mL | 3.2514 mL | |
| 80 mM | 0.0975 mL | 0.4877 mL | 0.9754 mL | 2.4385 mL | |
| 100 mM | 0.0780 mL | 0.3902 mL | 0.7803 mL | 1.9508 mL |
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