Nω-Propyl-L-arginine hydrochloride
Based on 1 publication(s) in Google Scholar
Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) hydrochloride is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a Ki of 57 nM. Nω-Propyl-L-arginine hydrochloride displays a 149-fold selectivity for nNOS over endothelial NOS (eNOS).
For research use only. We do not sell to patients.
- Purity: 99.88%
- CAS No.: 2321366-46-3
- Formula: C9H21ClN4O2
- Molecular Weight:252.74
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Nω-Propyl-L-arginine hydrochloride
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Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male NMRI mice (30-40 g) (phencyclidine-induced stimulation)[2]
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Dosage:20 mg/kg
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Administration:I.p.
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Result:Markedly reduced the phencyclidineinduced disruption of prepulse inhibition and significantly reduced the phencyclidine-induced stimulation of locomotor activity.
Chemical Information
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CAS No. 2321366-46-3
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Appearance Oil
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Molecular Weight 252.74
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Formula C9H21ClN4O2
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Color Colorless to off-white
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SMILES
N[C@@H](CCCNC(NCCC)=N)C(O)=O.[H]Cl
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Synonyms
N-omega-Propyl-L-arginine hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Cancer Metab
Hypoxia-induced NOS1 as a therapeutic target in hypercholesterolemia-related colorectal cancer. [Abstract]2024 May 17;12(1):14. PMID: 38755702
Solvent & Solubility
DMSO : 25 mg/mL (98.92 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 25 mg/mL (98.92 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Zhang HQ, et al. Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine. J Med Chem. 1997 Nov 21;40(24):3869-70. [Content Brief]
[2]. Klamer D, et al. The neuronal selective nitric oxide synthase inhibitor, Nomega-propyl-L-arginine, blocks the effects of phencyclidine on prepulse inhibition and locomotor activity in mice. Eur J Pharmacol. 2004 Oct 25;503(1-3):103-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 3.9566 mL | 19.7832 mL | 39.5664 mL | 98.9159 mL |
| 5 mM | 0.7913 mL | 3.9566 mL | 7.9133 mL | 19.7832 mL | |
| 10 mM | 0.3957 mL | 1.9783 mL | 3.9566 mL | 9.8916 mL | |
| 15 mM | 0.2638 mL | 1.3189 mL | 2.6378 mL | 6.5944 mL | |
| 20 mM | 0.1978 mL | 0.9892 mL | 1.9783 mL | 4.9458 mL | |
| 25 mM | 0.1583 mL | 0.7913 mL | 1.5827 mL | 3.9566 mL | |
| 30 mM | 0.1319 mL | 0.6594 mL | 1.3189 mL | 3.2972 mL | |
| 40 mM | 0.0989 mL | 0.4946 mL | 0.9892 mL | 2.4729 mL | |
| 50 mM | 0.0791 mL | 0.3957 mL | 0.7913 mL | 1.9783 mL | |
| 60 mM | 0.0659 mL | 0.3297 mL | 0.6594 mL | 1.6486 mL | |
| 80 mM | 0.0495 mL | 0.2473 mL | 0.4946 mL | 1.2364 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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