1. Anti-infection
  2. SARS-CoV
  3. Direct Violet 1

Direct Violet 1 

Cat. No.: HY-D1270
Handling Instructions

Direct Violet 1, an azo dye, is a textile dye. Direct Violet 1 is also the protein-protein interaction (PPI) between the SARS-CoV-2 spike protein and ACE2 inhibitor with IC50s of 1.47-2.63 µM.

For research use only. We do not sell to patients.

Direct Violet 1 Chemical Structure

Direct Violet 1 Chemical Structure

CAS No. : 2586-60-9

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Description

Direct Violet 1, an azo dye, is a textile dye. Direct Violet 1 is also the protein-protein interaction (PPI) between the SARS-CoV-2 spike protein and ACE2 inhibitor with IC50s of 1.47-2.63 µM[1][2].

IC50 & Target

IC50: 1.47 µM (SARS-CoV-2-S-RBD binding to ACE2); 2.63 µM (SARS-CoV-S1S2 binding to ACE2); 2.11 µM (TNF-R1-TNFα binding)[1]

In Vitro

Direct Violet 1 inhibits SARS-CoV-2-S-RBD binding to human ACE2, inhibits SARS-CoV-S1S2 binding to ACE2, and inhibits TNF-R1 binding to TNFα with IC50 values of 1.47 µM, 2.63 µM, and 2.11 µM, respectively[1].
Direct Violet 1 inhibits SARS-CoV-2 pseudovirus entry into hACE2 expressing host cells in a concentration-dependent manner with an IC50 of 35.8 µM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

728.66

Formula

C₃₂H₂₂N₆Na₂O₈S₂

CAS No.

2586-60-9

SMILES

O=S(C1=CC(O)=C2C(/N=N/C3=CC=C(C4=CC=C(/N=N/C5=C(N)C=CC6=CC(S(=O)(O[Na])=O)=CC(O)=C56)C=C4)C=C3)=C(N)C=CC2=C1)(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Direct Violet 1Direct Violet1Direct Violet-1SARS-CoVSARS coronavirusCOVID-19antiviralSARS-CoV-2ACE2SARS-CoV-S1S2TNF-R1TNFαpikeInhibitorinhibitorinhibit

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Direct Violet 1
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