ST-148
ST-148 is a novel small molecule compound that has potent inhibitory effects against all four dengue virus serotypes. In the nonlethal AG129 mouse dengue virus infection model, ST-148 significantly reduced viremia and viral load in vital organs and tended to reduce plasma cytokine levels. Compound resistance was associated with the dengue virus capsid (C) gene, and the direct interaction of ST-148 with the C protein was presumed to be achieved through the protein's built-in fluorescence change in the presence of the compound. Therefore, ST-148 appears to interact with the dengue virus C protein and inhibit one or more unique steps of the viral replication cycle.
For research use only. We do not sell to patients.
- CAS No.: 400863-77-6
- Formula: C21H19N5OS2
- Molecular Weight:421.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Other In-stock Forms of ST-148
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Biological Activity
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Chemical Information
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | EC50 |
0.016 μM
Compound: 12
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Antiviral activity against Dengue virus 2 NGC infected in african green monkey Vero cells assessed as reduction in viral titer after 48 hrs by plaque assay
Antiviral activity against Dengue virus 2 NGC infected in african green monkey Vero cells assessed as reduction in viral titer after 48 hrs by plaque assay
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[PMID: 26771861] |
Chemical Information
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CAS No. 400863-77-6
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Molecular Weight 421.54
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Formula C21H19N5OS2
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SMILES
O=C(NC1=NN=C(S1)C2=CC=CC=C2)C3=C(C4=CC5=C(N=C4S3)CCCCC5)N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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