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Vepsitamab

(別名: AMG 199)
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Based on 1 Customer Validation

Vepsitamab (AMG 199) is a bispecific T-cell engager (HLE BiTE) that binds to MUC17 and CD3. Vepsitamab directs CD3-positive cells to target MUC17-positive cells. Vepsitamab induces cell activation and proliferation. Vepsitamab is applicable to research related to gastric cancer and gastroesophageal junction (g/gej) cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

  • 純度 : 98.44%
  • CAS 番号: 2413453-53-7
  • 分子量:105 kDa
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Vepsitamab
  • Experimental Validation Results for Vepsitamab
  • Experimental Validation Results for Vepsitamab
  • Experimental Validation Results for Vepsitamab
  • Vepsitamab Chemical Structure
    Vepsitamab 構造式
CAS 番号: 2413453-53-7
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    (scFv-heavy-lambda)-(scFv-heavy-lambda)-scFc

  • 1/16

    Immobilized Vepsitamab can bind Human MUC17 Protein (His Tag). The EC50 for this effect is 2.10 ng/mL.

  • 1/16

    Immobilized Vepsitamab can bind Human CD3 epsilon/CD3e Protein (ECD, His Tag). The EC50 for this effect is 2.35 ng/mL.

  • 1/16

    Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Vepsitamab (HY-P99523). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control.

  • Vepsitamab Chemical Structure
    1/16
  • Vepsitamab
  • Immobilized Vepsitamab can bind Human MUC17 Protein (His Tag). The EC50 for this effect is 2.10 ng/mL.
  • Immobilized Vepsitamab can bind Human CD3 epsilon/CD3e Protein (ECD, His Tag). The EC50 for this effect is 2.35 ng/mL.
  • Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Vepsitamab (HY-P99523). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control.
  • (scFv-heavy-lambda)-(scFv-heavy-lambda)-scFc