1. Anti-infection
    Cell Cycle/DNA Damage
  2. Bacterial
    Antibiotic
    TOPK
  3. Cephradine monohydrate

Cephradine monohydrate (Synonyms: Cefradine monohydrate)

Cat. No.: HY-128449
Handling Instructions

Cephradine (Cefradine) monohydrate is a broad-spectrum and orally active cephalosporin. Cephradine monohydrate is active against both grampositive and gram-negative pathogens and effective in eradicating most penicillinase-producing organisms known to be resistant to penicillin G, penicillin V, and ampicillin. Cephradine monohydrate has been used in the research of genitourinary, gastrointestinal and respiratory tract infections, and in infections of the skin and soft tissues. Cephradine monohydrate blocks solar-ultraviolet induced skin inflammation through direct inhibition of TOPK.

For research use only. We do not sell to patients.

Cephradine monohydrate Chemical Structure

Cephradine monohydrate Chemical Structure

CAS No. : 75975-70-1

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Description

Cephradine (Cefradine) monohydrate is a broad-spectrum and orally active cephalosporin. Cephradine monohydrate is active against both grampositive and gram-negative pathogens and effective in eradicating most penicillinase-producing organisms known to be resistant to penicillin G, penicillin V, and ampicillin. Cephradine monohydrate has been used in the research of genitourinary, gastrointestinal and respiratory tract infections, and in infections of the skin and soft tissues. Cephradine monohydrate blocks solar-ultraviolet induced skin inflammation through direct inhibition of TOPK[1][2][3].

IC50 & Target

Bacteria[1].
Antibiotic[1].
TOPK[3].

In Vitro

Cephradine (0~8 μg/mL; 12 hours) makes bacterial viability rapidly increased at antibiotic concentrations below the MIC (minimum inhibitory concentration) of 0.70 µg/mL at both pH 7.4 and pH 5.5[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cephradine (25 mg/kg; s.c.; 11 days) reduces the bacterial density and counts in the abscesses[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nondiabetic mice
Dosage: 25 mg/kg
Administration: S.c.; 11 days
Result: Reduced the bacterial density and counts in the abscesses.
Clinical Trial
Molecular Weight

367.42

Formula

C₁₆H₂₁N₃O₅S

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
Cephradine monohydrate
Cat. No.:
HY-128449
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