2. Anti-infection Cell Cycle/DNA Damage
  3. Bacterial Antibiotic TOPK
  4. Cephradine

Cephradine  (Synonyms: Cefradine; SQ-11436)

Cat. No.: HY-B1156 Purity: 95.11%
COA Handling Instructions

Cephradine (Cefradine) is a broad-spectrum and orally active cephalosporin. Cephradine is active against both gram-positive and gram-negative pathogens. Cephradine is effective in eradicating most penicillinase-producing organisms. Cephradine has been used in the research of genitourinary, gastrointestinal and respiratory tract infections, and in infections of the skin and soft tissues. Cephradine blocks solar-ultraviolet induced skin inflammation through direct inhibition of TOPK.

For research use only. We do not sell to patients.

Cephradine Chemical Structure

Cephradine Chemical Structure

CAS No. : 38821-53-3

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10 mM * 1 mL in DMSO USD 87 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Cephradine:

Cephradine Related Antibodies

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1 Publications Citing Use of MCE Cephradine

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

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Description

Cephradine (Cefradine) is a broad-spectrum and orally active cephalosporin. Cephradine is active against both gram-positive and gram-negative pathogens. Cephradine is effective in eradicating most penicillinase-producing organisms. Cephradine has been used in the research of genitourinary, gastrointestinal and respiratory tract infections, and in infections of the skin and soft tissues. Cephradine blocks solar-ultraviolet induced skin inflammation through direct inhibition of TOPK[1][2][3].

IC50 & Target

β-lactam

 

In Vitro

Cephradine (0~8 μg/mL; 12 hours) makes bacterial viability rapidly increased at antibiotic concentrations below the MIC (minimum inhibitory concentration) of 0.70 µg/mL at both pH 7.4 and pH 5.5[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cephradine Related Antibodies
In Vivo

Cephradine (25 mg/kg; s.c.; 11 days) reduces the bacterial density and counts in the abscesses[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nondiabetic mice
Dosage: 25 mg/kg
Administration: S.c.; 11 days
Result: Reduced the bacterial density and counts in the abscesses.
Clinical Trial
Molecular Weight

349.40

Appearance

Solid

Formula

C16H19N3O4S
CAS No.
SMILES

O=C(C(N12)=C(C)CS[C@]2([H])[C@H](NC([C@H](N)C3=CCC=CC3)=O)C1=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 8.33 mg/mL (23.84 mM; Need ultrasonic)

DMSO : ≥ 3.6 mg/mL (10.30 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8620 mL 14.3102 mL 28.6205 mL
5 mM 0.5724 mL 2.8620 mL 5.7241 mL
10 mM 0.2862 mL 1.4310 mL 2.8620 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 4.55 mg/mL (13.02 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Cephradine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Cephradine38821-53-3Cefradine SQ-11436SQ11436SQ 11436SQ-11436BacterialAntibioticTOPKT-LAK cell-originated protein kinaseOralGrampositiveGram-negativeGenitourinaryGastrointestinalInfectionsInhibitorinhibitorinhibit

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