1. Anti-infection
    Cell Cycle/DNA Damage
  2. Bacterial
    Antibiotic
    TOPK
  3. Cephradine

Cephradine (Synonyms: Cefradine; SQ-11436)

Cat. No.: HY-B1156 Purity: 95.11%
Handling Instructions

Cephradine (Cefradine) is a broad-spectrum and orally active cephalosporin. Cephradine is active against both gram-positive and gram-negative pathogens. Cephradine is effective in eradicating most penicillinase-producing organisms. Cephradine has been used in the research of genitourinary, gastrointestinal and respiratory tract infections, and in infections of the skin and soft tissues. Cephradine blocks solar-ultraviolet induced skin inflammation through direct inhibition of TOPK.

For research use only. We do not sell to patients.

Cephradine Chemical Structure

Cephradine Chemical Structure

CAS No. : 38821-53-3

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 79 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 72 In-stock
Estimated Time of Arrival: December 31
500 mg USD 132 In-stock
Estimated Time of Arrival: December 31
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5 g   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Top Publications Citing Use of Products

1 Publications Citing Use of MCE Cephradine

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  • References

  • Customer Review

Description

Cephradine (Cefradine) is a broad-spectrum and orally active cephalosporin. Cephradine is active against both gram-positive and gram-negative pathogens. Cephradine is effective in eradicating most penicillinase-producing organisms. Cephradine has been used in the research of genitourinary, gastrointestinal and respiratory tract infections, and in infections of the skin and soft tissues. Cephradine blocks solar-ultraviolet induced skin inflammation through direct inhibition of TOPK[1][2][3].

IC50 & Target

Bacteria[1].
Antibiotic[1].
TOPK[3].

In Vitro

Cephradine (0~8 μg/mL; 12 hours) makes bacterial viability rapidly increased at antibiotic concentrations below the MIC (minimum inhibitory concentration) of 0.70 µg/mL at both pH 7.4 and pH 5.5[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cephradine (25 mg/kg; s.c.; 11 days) reduces the bacterial density and counts in the abscesses[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nondiabetic mice
Dosage: 25 mg/kg
Administration: S.c.; 11 days
Result: Reduced the bacterial density and counts in the abscesses.
Clinical Trial
Molecular Weight

349.40

Formula

C₁₆H₁₉N₃O₄S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 8.33 mg/mL (23.84 mM; Need ultrasonic)

DMSO : ≥ 3.6 mg/mL (10.30 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8620 mL 14.3102 mL 28.6205 mL
5 mM 0.5724 mL 2.8620 mL 5.7241 mL
10 mM 0.2862 mL 1.4310 mL 2.8620 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Cephradine
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