1. Metabolic Enzyme/Protease
  2. Aldehyde Dehydrogenase (ALDH)
  3. CM121

CM121 

Cat. No.: HY-139032
Handling Instructions

CM121 is an active site-directed reversible ALDH1A2 inhibitor (IC50=0.54 μM;Kd=1.1 μM) with a variety of hydrophobic interactions.

For research use only. We do not sell to patients.

CM121 Chemical Structure

CM121 Chemical Structure

CAS No. : 2204230-40-8

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Description

CM121 is an active site-directed reversible ALDH1A2 inhibitor (IC50=0.54 μM;Kd=1.1 μM) with a variety of hydrophobic interactions[1].

IC50 & Target

IC50: 0.54 μM (ALDH1A2), Kd: 1.1 μM (ALDH1A2)[1]

In Vitro

CM121 interacts with the main-chain amides of Cys320 and Thr321 and the side-chains of Thr321 and Asn187 via methylsulfonyl oxygen. CM121 establishes π-π stacking with the side chains of PHE188 and PHE314 through methylsulfonyl benzene and benzylonitrile rings[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

460.48

Formula

C₂₄H₁₇FN₄O₃S

CAS No.
SMILES

O=C(C1=CN(C2=CC=C(C#N)C=C2)N=C1C3=CC=C(S(=O)(C)=O)C=C3)NC4=CC=CC(F)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CM121CM 121CM-121Aldehyde Dehydrogenase (ALDH)Cys320Thr321Asn187MethylsulfonylOxygensBenzeneHydrophobicBL21Star (DE3)Inhibitorinhibitorinhibit

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