1. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage Cytoskeleton
  2. Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin
  3. Cantuzumab mertansine

Cantuzumab mertansine  (Synonyms: SB-408075; huC242-DM1)

Cat. No.: HY-P99492

Cantuzumab mertansine (SB-408075; huC242-DM1), an ADC, is an immunoconjugate of the potent maytansine derivative (DM1; HY-19792) and the humanized monoclonal antibody (huC242) directed to CanAg. Cantuzumab mertansine has cytotoxic toward colon cancer cells and has broad antitumor efficacy against a range of CanAg-positive human tumor xenografts.

For research use only. We do not sell to patients.

Cantuzumab mertansine Chemical Structure

Cantuzumab mertansine Chemical Structure

CAS No. : 400010-39-1

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Description

Cantuzumab mertansine (SB-408075; huC242-DM1), an ADC, is an immunoconjugate of the potent maytansine derivative (DM1; HY-19792) and the humanized monoclonal antibody (huC242) directed to CanAg. Cantuzumab mertansine has cytotoxic toward colon cancer cells and has broad antitumor efficacy against a range of CanAg-positive human tumor xenografts[1][2].

In Vitro

Cantuzumab mertansine (SB-408075; huC242-DM1; 0-100 μM; 24 h) has selective cytotoxic activity on antigen-positive COLO 205 cell line[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: Antigen-positive COLO 205 cell line and the antigen-negative A-375 melanoma cell line
Concentration: 0-100 μM
Incubation Time: 24 h
Result: Had cytotoxic activity on COLO 205 cells with an IC50 value of 0.032 nM (23.5 pg/ml).
Had 1100-fold less cytotoxic activity for the antigen-negative A-375 cells (IC50=36 nM; 26.5 ng/ml).
In Vivo

Cantuzumab mertansine (SB-408075; huC242-DM1; 300 μg/kg/day for 5 days) resultes in complete regressions and cures of mice bearing human xenografts of COLO 205 colon cancer[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CB-17 SCID mice, 6-7 weeks of age bearing COLO 205 human colon tumor xenografts[1]
Dosage: 300 μg/kg
Administration: Daily for 5 days
Result: Completely eliminated any measurable tumors within 2 weeks of the initiation of therapy, and all eight animals were tumor-free for 200 days (duration of the experiment).
CAS No.
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[Cantuzumab mertansine]

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