1. Cell Cycle/DNA Damage
    Epigenetics
  2. Aurora Kinase
  3. Aurora Kinase Inhibitor 3

Aurora Kinase Inhibitor 3 

Cat. No.: HY-112373
Handling Instructions

Aurora Kinase Inhibitor 3 is a strong and selective Aurora A kinase inhibitor with an IC50 of 42 nM, and weakly inhibits EGFR with an IC50>10 μM. Aurora Kinase Inhibitor 3 has a binding mode with the cyclopropanecarboxylic acid moiety directed towards the solvent exposed region of the ATP-binding pocket, and several induced structural changes in the active-site compared with other published AIK structures.

For research use only. We do not sell to patients.

Aurora Kinase Inhibitor 3 Chemical Structure

Aurora Kinase Inhibitor 3 Chemical Structure

CAS No. : 879127-16-9

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Description

Aurora Kinase Inhibitor 3 is a strong and selective Aurora A kinase inhibitor with an IC50 of 42 nM, and weakly inhibits EGFR with an IC50>10 μM. Aurora Kinase Inhibitor 3 has a binding mode with the cyclopropanecarboxylic acid moiety directed towards the solvent exposed region of the ATP-binding pocket, and several induced structural changes in the active-site compared with other published AIK structures[1].

IC50 & Target[1]

Aurora A

42 nM (IC50)

Molecular Weight

413.40

Formula

C₂₁H₁₈F₃N₅O

CAS No.

879127-16-9

SMILES

O=C(C1CC1)NC2=CC=CC(NC3=NC=CC(NC4=CC=CC(C(F)(F)F)=C4)=N3)=C2

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Room temperature in continental US; may vary elsewhere

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Aurora Kinase Inhibitor 3
Cat. No.:
HY-112373
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