879127-16-9
879127-16-9
Chemical Structure
Aurora kinase inhibitor-3
- CAS No.: 879127-16-9
- Formula:C21H18F3N5O
- Molecular Weight:413.40
IUPAC Name: N-(3-((4-((3-(trifluoromethyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)cyclopropanecarboxamide
InChIKey: RDTDWGQDFJPTPD-UHFFFAOYSA-N
SMILES: O=C(C1CC1)NC2=CC=CC(NC3=NC=CC(NC4=CC=CC(C(F)(F)F)=C4)=N3)=C2
Biological Activity: Aurora kinase inhibitor-3 is a strong and selective Aurora A kinase inhibitor with an IC50 of 42 nM, and weakly inhibits EGFR with an IC50 of >10 μM. Aurora kinase inhibitor-3 has a binding mode with the cyclopropanecarboxylic acid moiety directed towards the solvent exposed region of the ATP-binding pocket[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Aurora kinase inhibitor-3 | 99.05% | Aurora kinase inhibitor-3 is a strong and selective Aurora A kinase inhibitor with an IC50 of 42 nM, and weakly inhibits EGFR with an IC50 of >10 μM. Aurora kinase inhibitor-3 has a binding mode with the cyclopropanecarboxylic acid moiety directed towards the solvent exposed region of the ATP-binding pocket. | ||||||||||||||||||||
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