dCeMM1
Based on 1 Customer Validation
dCeMM1 is a RBM39 glue degrader. dCeMM1 shows functions by re-directing the activity of the CRL4DCAF15 ligase. dCeMM1 decreases the expression of RBM39 levels in WT KBM7 cells.
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- Reinheit: 99.53%
- CAS. Nr.: 118719-16-7
- Formel: C14H13BrN2O3S
- Molecular Weight:369.23
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
dCeMM1 (0-100 µM; 3 days) inhibits cell growth with EC50s of 3, 8 µM for WT and UBE2Mmut KBM7 cells, respectively[1].
dCeMM1 (10 µM; 12, 16 h) decreases the expression of RBM39 levels in WT KBM7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:WT and UBE2Mmut KBM7 cells
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Concentration:10 µM
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Incubation Time:12, 16 h
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Result:Decreased the expression of RBM39 levels in WT KBM7 cells.
Chemical Information
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CAS. Nr. 118719-16-7
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Appearance Solid
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Molecular Weight 369.23
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Formel C14H13BrN2O3S
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Color White to off-white
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SMILES
O=S(C1=CC=C(C)C=C1)(NN=CC2=CC(Br)=CC=C2O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (270.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (270 KB)
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SDS (630 KB)
- English - EN (630 KB)
- Français - FR (630 KB)
- Deutsch - DE (630 KB)
- Norwegian - NO (630 KB)
- Español - ES (630 KB)
- Swedish - SV (630 KB)
- Italian - IT (630 KB)
- Korean - KR (630 KB)
- Portuguese - PT (630 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7083 mL | 13.5417 mL | 27.0834 mL | 67.7085 mL |
| 5 mM | 0.5417 mL | 2.7083 mL | 5.4167 mL | 13.5417 mL | |
| 10 mM | 0.2708 mL | 1.3542 mL | 2.7083 mL | 6.7708 mL | |
| 15 mM | 0.1806 mL | 0.9028 mL | 1.8056 mL | 4.5139 mL | |
| 20 mM | 0.1354 mL | 0.6771 mL | 1.3542 mL | 3.3854 mL | |
| 25 mM | 0.1083 mL | 0.5417 mL | 1.0833 mL | 2.7083 mL | |
| 30 mM | 0.0903 mL | 0.4514 mL | 0.9028 mL | 2.2569 mL | |
| 40 mM | 0.0677 mL | 0.3385 mL | 0.6771 mL | 1.6927 mL | |
| 50 mM | 0.0542 mL | 0.2708 mL | 0.5417 mL | 1.3542 mL | |
| 60 mM | 0.0451 mL | 0.2257 mL | 0.4514 mL | 1.1285 mL | |
| 80 mM | 0.0339 mL | 0.1693 mL | 0.3385 mL | 0.8464 mL | |
| 100 mM | 0.0271 mL | 0.1354 mL | 0.2708 mL | 0.6771 mL |
dCeMM1 Related Classifications
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