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  4. dCeMM1

dCeMM1 is a RBM39 glue degrader. dCeMM1 shows functions by re-directing the activity of the CRL4DCAF15 ligase. dCeMM1 decreases the expression of RBM39 levels in WT KBM7 cells.

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dCeMM1 Chemical Structure

dCeMM1 Chemical Structure

CAS No. : 118719-16-7

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Based on 1 publication(s) in Google Scholar

dCeMM1 Related Antibodies

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Description

dCeMM1 is a RBM39 glue degrader. dCeMM1 shows functions by re-directing the activity of the CRL4DCAF15 ligase. dCeMM1 decreases the expression of RBM39 levels in WT KBM7 cells[1].

In Vitro

dCeMM1 (0-100 µM; 3 days) inhibits cell growth with EC50s of 3, 8 µM for WT and UBE2Mmut KBM7 cells, respectively[1].
dCeMM1 (10 µM; 12, 16 h) decreases the expression of RBM39 levels in WT KBM7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

dCeMM1 Related Antibodies

Western Blot Analysis[1]

Cell Line: WT and UBE2Mmut KBM7 cells
Concentration: 10 µM
Incubation Time: 12, 16 h
Result: Decreased the expression of RBM39 levels in WT KBM7 cells.
Molecular Weight

369.23

Formula

C14H13BrN2O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C(C)C=C1)(NN=CC2=CC(Br)=CC=C2O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (270.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7083 mL 13.5417 mL 27.0834 mL
5 mM 0.5417 mL 2.7083 mL 5.4167 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7083 mL 13.5417 mL 27.0834 mL 67.7085 mL
5 mM 0.5417 mL 2.7083 mL 5.4167 mL 13.5417 mL
10 mM 0.2708 mL 1.3542 mL 2.7083 mL 6.7708 mL
15 mM 0.1806 mL 0.9028 mL 1.8056 mL 4.5139 mL
20 mM 0.1354 mL 0.6771 mL 1.3542 mL 3.3854 mL
25 mM 0.1083 mL 0.5417 mL 1.0833 mL 2.7083 mL
30 mM 0.0903 mL 0.4514 mL 0.9028 mL 2.2569 mL
40 mM 0.0677 mL 0.3385 mL 0.6771 mL 1.6927 mL
50 mM 0.0542 mL 0.2708 mL 0.5417 mL 1.3542 mL
60 mM 0.0451 mL 0.2257 mL 0.4514 mL 1.1285 mL
80 mM 0.0339 mL 0.1693 mL 0.3385 mL 0.8464 mL
100 mM 0.0271 mL 0.1354 mL 0.2708 mL 0.6771 mL
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dCeMM1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

dCeMM1118719-16-7dCeMM 1dCeMM-1Molecular GluesInhibitorinhibitorinhibit

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