118719-16-7
Chemical Structure
dCeMM1
- CAS No.: 118719-16-7
- Formula:C14H13BrN2O3S
- Molecular Weight:369.23
IUPAC Name: (E)-N'-(5-bromo-2-hydroxybenzylidene)-4-methylbenzenesulfonohydrazide
InChIKey: PBEIAQYKTXKQGF-CXUHLZMHSA-N
SMILES: O=S(C1=CC=C(C)C=C1)(NN=CC2=CC(Br)=CC=C2O)=O
Biological Activity: dCeMM1 is a molecular glue degrader that targets RBM39. dCeMM1 serves as a positive control for the screening of DCAF15-dependent molecular glue degraders. dCeMM1 promotes the DCAF15-RBM39 interaction, thereby recruiting RBM39 to the CRL4DCAF15 E3 ubiquitin ligase complex, inducing ubiquitination and subsequent proteasomal degradation of RBM39. Meanwhile, dCeMM1 stabilizes DCAF15 by mediating neo-substrate recruitment to protect DCAF15 from autodegradation. dCeMM1 reduces the viability of leukemia cells in a neddylation-dependent and proteasome-dependent manner, and can be applied in leukemia-related research[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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dCeMM1 | 99.53% | dCeMM1 is a molecular glue degrader that targets RBM39. dCeMM1 serves as a positive control for the screening of DCAF15-dependent molecular glue degraders. dCeMM1 promotes the DCAF15-RBM39 interaction, thereby recruiting RBM39 to the CRL4DCAF15 E3 ubiquitin ligase complex, inducing ubiquitination and subsequent proteasomal degradation of RBM39. Meanwhile, dCeMM1 stabilizes DCAF15 by mediating neo-substrate recruitment to protect DCAF15 from autodegradation. dCeMM1 reduces the viability of leukemia cells in a neddylation-dependent and proteasome-dependent manner, and can be applied in leukemia-related research. | ||||||||||||||||||||
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References
- [1]. Dong G, et al. Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery. Journal of medicinal chemistry. 2021 Aug 12;64(15):10606-10620. [Content Brief]
- [2]. Mayor-Ruiz C, et al. Rational discovery of molecular glue degraders via scalable chemical profiling. Nature chemical biology. 2020 Nov;16(11):1199-1207. [Content Brief]
- [3]. Rodríguez-Gimeno A, et al. Drug Discovery Approaches to Target E3 Ligases. Chembiochem : a European journal of chemical biology. 2025 Jan 02;26(1):e202400656.
- [4]. King EA, et al. Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB. Cell chemical biology. 2023 Apr 20;30(4):394-402.e9. [Content Brief]
- [5]. Sasso JM, et al. Molecular Glues: The Adhesive Connecting Targeted Protein Degradation to the Clinic. Biochemistry. 2023 Feb 07;62(3):601-623.
