BD-Oligo
Based on 1 Customer Validation
BD-Oligo is an oligomer-specific fluorescent chemical probe. BD-Oligo preferentially identifies Aβ oligomer assemblies over monomers or fibrils by using diversity-directed fluorescent library (DOFL) screening and computational techniques. BD-Oligo exhibits dynamic oligomer monitoring capabilities during Aβ peptide fibril formation as Aβ is induced to form oligomers and ultimately fibrils over time. BD-Oligo also exhibits blood-brain barrier permeability with the ability to stain Aβ oligomers in vivo.
For research use only. We do not sell to patients.
- Purity : 98.18%
- CAS No.: 1357578-02-9
- Formula: C25H24BCl3F2N2O4
- Molecular Weight:571.64
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Chemical Information
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CAS No. 1357578-02-9
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Appearance Solid
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Molecular Weight 571.64
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Formula C25H24BCl3F2N2O4
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Color Brown to reddish brown
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SMILES
OC(C(OCC)=CC=C1)=C1/C=C/C2=[N]3C(C(C)=C2)=CC4=CC=C(CCC(OCC(Cl)(Cl)Cl)=O)[N-]4[B+3]3([F-])[F-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (174.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Transepithelial/transendothelial electrical resistance assay
TEER measures electrical resistance across epithelial or endothelial monolayers cultured on permeable supports, and the readout reflects ionic conductance through the cell barrier, especially the paracellular pathway regulated by junctional integrity. TEER can be measured without destroying the monolayer and is commonly used before or during transport, permeability, barrier-disruption, and barrier-maturation experiments. TEER values are influenced by biological maturation and technical conditions; reported factors include temperature, medium formulation, passage number, electrode geometry, membrane properties, and junctional length during early monolayer maturation. Therefore, TEER should be interpreted with blank-insert subtraction, area normalization, repeated readings, and, when possible, orthogonal barrier readouts such as FITC-dextran flux or tight-junction staining.
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7494 mL | 8.7468 mL | 17.4935 mL | 43.7338 mL |
| 5 mM | 0.3499 mL | 1.7494 mL | 3.4987 mL | 8.7468 mL | |
| 10 mM | 0.1749 mL | 0.8747 mL | 1.7494 mL | 4.3734 mL | |
| 15 mM | 0.1166 mL | 0.5831 mL | 1.1662 mL | 2.9156 mL | |
| 20 mM | 0.0875 mL | 0.4373 mL | 0.8747 mL | 2.1867 mL | |
| 25 mM | 0.0700 mL | 0.3499 mL | 0.6997 mL | 1.7494 mL | |
| 30 mM | 0.0583 mL | 0.2916 mL | 0.5831 mL | 1.4578 mL | |
| 40 mM | 0.0437 mL | 0.2187 mL | 0.4373 mL | 1.0933 mL | |
| 50 mM | 0.0350 mL | 0.1749 mL | 0.3499 mL | 0.8747 mL | |
| 60 mM | 0.0292 mL | 0.1458 mL | 0.2916 mL | 0.7289 mL | |
| 80 mM | 0.0219 mL | 0.1093 mL | 0.2187 mL | 0.5467 mL | |
| 100 mM | 0.0175 mL | 0.0875 mL | 0.1749 mL | 0.4373 mL |
BD-Oligo Related Classifications
HY-171179 Related Classifications
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