1. Cell Cycle/DNA Damage
    Epigenetics
    PI3K/Akt/mTOR
    Apoptosis
  2. HDAC
    Akt
    Apoptosis
  3. MPT0E028

MPT0E028 

Cat. No.: HY-124295
Handling Instructions

MPT0E028 is an orally active and selective HDAC inhibitor with IC50s of 53.0 nM, 106.2 nM, 29.5 nM for HDAC1, HDAC2 and HDAC6, respectively. MPT0E028 reduces the viability of B-cell lymphomas by inducing apoptosis and possesses potent direct Akt targeting ability and reduces Akt phosphorylation in B-cell lymphoma. MPT0E028 has good anticancer activity.

For research use only. We do not sell to patients.

MPT0E028 Chemical Structure

MPT0E028 Chemical Structure

CAS No. : 1338320-94-7

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Description

MPT0E028 is an orally active and selective HDAC inhibitor with IC50s of 53.0 nM, 106.2 nM, 29.5 nM for HDAC1, HDAC2 and HDAC6, respectively[1]. MPT0E028 reduces the viability of B-cell lymphomas by inducing apoptosis and possesses potent direct Akt targeting ability and reduces Akt phosphorylation in B-cell lymphoma. MPT0E028 has good anticancer activity[2].

IC50 & Target[1,2]

HDAC1

53.0 nM (IC50)

HDAC2

106.2 nM (IC50)

HDAC6

29.5 nM (IC50)

HDAC8

2532.6 nM (IC50)

Akt

 

Molecular Weight

344.38

Formula

C₁₇H₁₆N₂O₄S

CAS No.

1338320-94-7

SMILES

O=C(/C=C/C1=CC2=C(C=C1)N(CC2)S(=O)(C3=CC=CC=C3)=O)NO

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Please store the product under the recommended conditions in the Certificate of Analysis.

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MPT0E028
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HY-124295
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