2. Anti-infection
  3. SARS-CoV
  4. SARS-CoV-2-IN-122

SARS-CoV-2-IN-122 is a SARS-CoV-2 inhibitor by targeting the S2 subunit of the spike protein. SARS-CoV-2-IN-122 interacts with residues linked to membrane fusion-associated conformational rearrangements, interfering with viral entry events. SARS-CoV-2-IN-122 inhibits SARS-CoV-2 replication, lacks direct virucidal activity, and does not impair viral-host cell attachment. SARS-CoV-2-IN-122 exhibits activity against SARS-CoV-2 variants including B.1 and Omicron (BA.2.86.1). SARS-CoV-2-IN-122 can be used for the research of coronavirus disease 2019 (COVID-19).

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SARS-CoV-2-IN-122

SARS-CoV-2-IN-122 Chemical Structure

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SARS-CoV-2-IN-122 Related Antibodies

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Description

SARS-CoV-2-IN-122 is a SARS-CoV-2 inhibitor by targeting the S2 subunit of the spike protein. SARS-CoV-2-IN-122 interacts with residues linked to membrane fusion-associated conformational rearrangements, interfering with viral entry events. SARS-CoV-2-IN-122 inhibits SARS-CoV-2 replication, lacks direct virucidal activity, and does not impair viral-host cell attachment. SARS-CoV-2-IN-122 exhibits activity against SARS-CoV-2 variants including B.1 and Omicron (BA.2.86.1). SARS-CoV-2-IN-122 can be used for the research of coronavirus disease 2019 (COVID-19)[1].

In Vitro

SARS-CoV-2-IN-122 (Compound 11) inhibits the Omicron variant (BA.2.86.1 lineage) with an EC50 of 0.73 μM and a selectivity index of 20.99 in S-Fuse cells[1].
SARS-CoV-2-IN-122 inhibits viral replication with an EC50 of 1.53 μM and a selectivity index of 61.37 in Calu-3 human lung epithelial cells infected with the SARS-CoV-2 B.1 lineage[1].
SARS-CoV-2-IN-122 (0.01-10 μM; 1 h) lacks direct virucidal activity against the SARS-CoV-2 B.1 lineage[1].
SARS-CoV-2-IN-122 (0.01-10 μM; 1 h) does not inhibit adsorption of the SARS-CoV-2 B.1 lineage to Calu-3 human lung epithelial cells[1].
SARS-CoV-2-IN-122 exhibits microsomal stability with intrinsic clearances of 200, 260, and 387 mL/min/kg in human, rat, and mouse liver microsomes, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SARS-CoV-2-IN-122 Related Antibodies
Parmacokinetics
Species Dose Route Cmax Tmax T1/2 (Elimination) F CLblood CLunbound Vss
Mice[1] 3 mg/kg i.v. / / 7.2 h / 81.5 mL/min/kg 1164 mL/min/kg 16.5 L/kg
Mice[1] 10 mg/kg p.o. 0.03 μM 0.7 h 21.5 h 3.3 % / / /
Molecular Weight

412.55

Formula

C23H28N2O3S
SMILES

O=C(C1=C(CSC2=CC=CC=C2)N(C)C3=C1C=C(OC)C(CN(C)C)=C3)OCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SARS-CoV-2-IN-122 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SARS-CoV-2-IN-122SARS-CoVSARS coronavirusCalu-3 human lung epithelial cellsSARS-CoV-2 variantsOmicron (BA.2.86.1)coronavirus disease 2019 (covid-19)viral entryB.1membrane fusionSARS-CoV-2 spike protein S2 subunitS-Fuse cellsSARS-CoV-2Inhibitorinhibitorinhibit

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