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Cat. No.: HY-182913

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SARS-CoV-2-IN-122

SARS-CoV-2-IN-122 is a SARS-CoV-2 inhibitor by targeting the S2 subunit of the spike protein. SARS-CoV-2-IN-122 interacts with residues linked to membrane fusion-associated conformational rearrangements, interfering with viral entry events. SARS-CoV-2-IN-122 inhibits SARS-CoV-2 replication, lacks direct virucidal activity, and does not impair viral-host cell attachment. SARS-CoV-2-IN-122 exhibits activity against SARS-CoV-2 variants including B.1 and Omicron (BA.2.86.1). SARS-CoV-2-IN-122 can be used for the research of coronavirus disease 2019 (COVID-19).

For research use only. We do not sell to patients.

Formula: C₂₃H₂₈N₂O₃S
Molecular Weight:412.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SARS-CoV-2-IN-122 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

SARS-CoV-2-IN-122 (Compound 11) inhibits the Omicron variant (BA.2.86.1 lineage) with an EC₅₀ of 0.73 μM and a selectivity index of 20.99 in S-Fuse cells^[1].
SARS-CoV-2-IN-122 inhibits viral replication with an EC₅₀ of 1.53 μM and a selectivity index of 61.37 in Calu-3 human lung epithelial cells infected with the SARS-CoV-2 B.1 lineage^[1].
SARS-CoV-2-IN-122 (0.01-10 μM; 1 h) lacks direct virucidal activity against the SARS-CoV-2 B.1 lineage^[1].
SARS-CoV-2-IN-122 (0.01-10 μM; 1 h) does not inhibit adsorption of the SARS-CoV-2 B.1 lineage to Calu-3 human lung epithelial cells^[1].
SARS-CoV-2-IN-122 exhibits microsomal stability with intrinsic clearances of 200, 260, and 387 mL/min/kg in human, rat, and mouse liver microsomes, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	T_max	T_1/2 (Elimination)	F	CL_blood	CL_unbound	V_ss
Mice^[1]	3 mg/kg	i.v.	/	/	7.2 h	/	81.5 mL/min/kg	1164 mL/min/kg	16.5 L/kg
Mice^[1]	10 mg/kg	p.o.	0.03 μM	0.7 h	21.5 h	3.3 %	/	/	/

Chemical Information

Molecular Weight 412.55
Formula C₂₃H₂₈N₂O₃S
SMILES

O=C(C1=C(CSC2=CC=CC=C2)N(C)C3=C1C=C(OC)C(CN(C)C)=C3)OCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mottin M, et al. Enhanced Antiviral Activity of Novel Umifenovir Derivatives against SARS-CoV-2: Insights from an International Collaborative Study[J]. ACS Omega, 2026.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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