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Cat. No.: HY-P11744

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Nuclear localizing sequence

Nuclear localizing sequence is a peptide sequence that functions as an inducer and exhibits membrane permeability in mammalian cells. Nuclear localizing sequence enhances cellular uptake and directs conjugated ruthenium (II) complexes to the nucleus for nuclear DNA imaging.

For research use only. We do not sell to patients.

CAS No.: 503474-42-8
Formula: C₅₅H₁₀₃N₂₁O₁₂S
Molecular Weight:1282.60

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Custom Peptide Synthesis

Nuclear localizing sequence Chemical Structure

CAS No.: 503474-42-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

The nuclear localizing sequence (Compound 12a) targets the conjugated [Ru (bpy)₂ (dppz)]²⁺ complex to the cell nucleus, and enables selective imaging of nuclear DNA by virtue of the "light-switch" emission behavior of this complex^[1].
Conjugation of the nuclear localizing sequence with a ruthenium (II) biquinoline complex bearing perchlorate counterions enables efficient cellular uptake in CHO and HeLa cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 503474-42-8
Molecular Weight 1282.60
Formula C₅₅H₁₀₃N₂₁O₁₂S
Sequence

Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-NH2
Sequence Shortening

VQRKRQKLMP-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lee LC, et al. Luminescent and Photofunctional Transition Metal Complexes: From Molecular Design to Diagnostic and Therapeutic Applications. J Am Chem Soc. 2022;144(32):14420-14440. [Content Brief]

[2]. Cullinane D, et al. Photostable NIR emitting ruthenium(II) conjugates; uptake and biological activity in live cells. J Inorg Biochem. 2020;207:111032. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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