503474-42-8
Chemical Structure
Nuclear localizing sequence
- CAS No.: 503474-42-8
- Formula:C55H103N21O12S
- Molecular Weight:1282.60
InChIKey: BWAXVCPHGSQXNT-IHHWSYFASA-N
SMILES: O=C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C(N1[C@@H](CCC1)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C(C)C)N
Biological Activity: Nuclear localizing sequence is a peptide sequence that functions as an inducer and exhibits membrane permeability in mammalian cells. Nuclear localizing sequence enhances cellular uptake and directs conjugated ruthenium (II) complexes to the nucleus for nuclear DNA imaging[1][2].
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Nuclear localizing sequence | Nuclear localizing sequence is a peptide sequence that functions as an inducer and exhibits membrane permeability in mammalian cells. Nuclear localizing sequence enhances cellular uptake and directs conjugated ruthenium (II) complexes to the nucleus for nuclear DNA imaging. | |||||||||||||||||||||
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- [1]. Lee LC, et al. Luminescent and Photofunctional Transition Metal Complexes: From Molecular Design to Diagnostic and Therapeutic Applications. J Am Chem Soc. 2022;144(32):14420-14440. [Content Brief]
- [2]. Cullinane D, et al. Photostable NIR emitting ruthenium(II) conjugates; uptake and biological activity in live cells. J Inorg Biochem. 2020;207:111032. [Content Brief]
Keywords
