1. Metabolic Enzyme/Protease
  2. Factor Xa
    Thrombin
  3. Edoxaban hydrochloride

Edoxaban hydrochloride (Synonyms: DU-176 hydrochloride)

Cat. No.: HY-10264C
Handling Instructions

Edoxaban (DU-176b) hydrochloride is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Ki values of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban hydrochloride exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban hydrochloride can be used for preventing thromboembolic disease research.

For research use only. We do not sell to patients.

Edoxaban hydrochloride Chemical Structure

Edoxaban hydrochloride Chemical Structure

CAS No. : 480448-29-1

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Description

Edoxaban (DU-176b) hydrochloride is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Ki values of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban hydrochloride exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban hydrochloride can be used for preventing thromboembolic disease research[1].

IC50 & Target

IC50: 2.90 µM (platelet aggregation), Ki: 0.561 nM (free human FXa), 2.98 nM (prothrombinase), 0.715 nM (cynomolgus monkey FXa), 0.457 nM (rabbit FXa)[1]

In Vitro

Edoxaban hydrochloride (1, 1 and 5 minutes respectively) prolongs PT,TT and APTT of human plasma in a concentration-dependent manner[1].
Edoxaban hydrochloride inhibits thrombin-induced platelet aggregation, with an IC50 of 2.90 µM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Human, rat, cynomolgus monkey and rabbit plasma; Human platelet
Concentration:
Incubation Time: 1 and 5 minutes
Result: Antithrombin.
In Vivo

Edoxaban hydrochloride (0.5, 2.5 and 12.5 mg/kg; p.o.; once) significantly and dose-dependently reduces the thrombus formation and prolongs PT[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Slc: Wistar rats (210-240 g); Male New Zealand White rabbits(2.5-3.5 kg) (Both are venous stasis thrombosis model)[1].
Dosage: 0.5, 2.5 and 12.5 mg/kg
Administration: Oral administration; once
Result: Inhibited exogenous FXa activity.
Antithrombotic.
Molecular Weight

584.52

Formula

C24H31Cl2N7O4S

CAS No.
SMILES

O=C(N(C)C)[[email protected]@H](CC1)C[[email protected]]([[email protected]]1NC(C(NC(C=C2)=NC=C2Cl)=O)=O)NC(C3=NC(CC4)=C(CN4C)S3)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Edoxaban hydrochloride
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HY-10264C
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