1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Protoporphyrin IX

Protoporphyrin IX 

Cat. No.: HY-B1247 Purity: ≥98.0%
COA Handling Instructions

Protoporphyrin IX is the final intermediate in the heme biosynthetic pathway.

For research use only. We do not sell to patients.

Protoporphyrin IX Chemical Structure

Protoporphyrin IX Chemical Structure

CAS No. : 553-12-8

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100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
250 mg USD 100 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 10 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Protoporphyrin IX purchased from MCE. Usage Cited in: Genome Biol. 2022 Dec 15;23(1):259.  [Abstract]

    Protoporphyrin IX (PpIX; 0, 5, 15, 25 µM; 2 h) rapidly results in increased nuclear G4 levels in HeLa cells. Immunostaining of G4 using BG4-EGFP (green). The nuclei are stained with DAPI (blue).

    Protoporphyrin IX purchased from MCE. Usage Cited in: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015 Jul;27(7):568-73.  [Abstract]

    To determine whether the inhibition of caveolin-1 tyrosine residues 14 ( Cav-1-Y14 ) phosphorylation with protein tyrosine kinase inhibitors ( PP2 ) will upregulate heme oxygenase-1 ( HO-1 ) activity to protect against ventilation induced lung injury in vivo of an animal model. The group D1 or D2 receive high tidal volume ventilation for 1 hour or 2 hour respectively, but they are given PP2 1 hour before high tidal volume ventilation. The groups E1 and E2 also receive high tidal volume ventilat
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    Protoporphyrin IX is the final intermediate in the heme biosynthetic pathway.

    IC50 & Target

    Human Endogenous Metabolite


    Clinical Trial
    Molecular Weight






    CAS No.


    Structure Classification

    Room temperature in continental US; may vary elsewhere.


    4°C, protect from light, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

    Solvent & Solubility
    In Vitro: 

    Ethanol : < 1 mg/mL (ultrasonic) (insoluble)

    DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)

    Purity & Documentation

    Purity: ≥98.0%

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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