HLF1-11
Based on 1 Customer Validation
HLF1-11, a human lactoferrin-derived peptide, is a broad spectrum antimicrobial agent. HLF1-11 inhibits human MPO activity. HLF1-11 also directs GM-CSF-driven monocyte differentiation toward macrophages, and enhances immune responses.
For research use only. We do not sell to patients.
- Purity: 99.73%
- CAS No.: 183623-03-2
- Formula: C56H95N25O14S
- Molecular Weight:1374.58
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Storage:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
hLF1-11 (1, 10, and 100 μg/mL) directs differentiation of monocytes toward a macrophage subset during granulocyte-macrophage colony-stimulating factor (GM-CSF)-driven monocytes differentiation[2].
hLF1-11 (0.5-250 μg/mL) inhibits human MPO activity[3].
hLF1-11 (100 μg/mL, 90 min) inhibits ROS induction induced by LPS in monocytes[3].
hLF1-11 (8-34 μΜ, 2 h) is active against fluconazole-resistant C. albicans[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
hLF1-11 (40 μg/kg, i.v.) is active against C. albicans-infected mice[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rabbits inoculated with CFU MRSA[4]
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Dosage:20 mg/kg
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Administration:Injected into the debrided tibial cavity
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Result:Reduced bacterial load compared to controls, and reduced the radiological and histopathological score.
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Animal Model:Neutropenic mice challenged i.v. with C. albicans
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Dosage:40 μg/kg
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Administration:Intravenous injection (i.v)
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Result:Reduced serum TNFα and IL-6 in infected mice.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 183623-03-2
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Appearance Solid
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Molecular Weight 1374.58
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Formula C56H95N25O14S
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Color White to off-white
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Sequence Shortening
GRRRRSVQWCA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (72.75 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 100 mg/mL (72.75 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[2]. van der Does AM, et al. Antimicrobial peptide hLF1-11 directs granulocyte-macrophage colony-stimulating factor-driven monocyte differentiation toward macrophages with enhanced recognition and clearance of pathogens. Antimicrob Agents Chemother. 2010 Feb;54(2):811-6. [Content Brief]
[3]. van der Does AM, et al. The human lactoferrin-derived peptide hLF1-11 exerts immunomodulatory effects by specific inhibition of myeloperoxidase activity. J Immunol. 2012 May 15;188(10):5012-9. [Content Brief]
[4]. Faber C, et al. Comparable efficacies of the antimicrobial peptide human lactoferrin 1-11 and gentamicin in a chronic methicillin-resistant Staphylococcus aureus osteomyelitis model. Antimicrob Agents Chemother. 2005 Jun;49(6):2438-44. [Content Brief]
[5]. Lupetti A, et al. Candidacidal activities of human lactoferrin peptides derived from the N terminus. Antimicrob Agents Chemother. 2000 Dec;44(12):3257-63. [Content Brief]
[6]. upetti A, et al. Human lactoferrin-derived peptide's antifungal activities against disseminated Candida albicans infection. J Infect Dis. 2007 Nov 1;196(9):1416-24. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 0.7275 mL | 3.6375 mL | 7.2749 mL | 18.1874 mL |
| 5 mM | 0.1455 mL | 0.7275 mL | 1.4550 mL | 3.6375 mL | |
| 10 mM | 0.0727 mL | 0.3637 mL | 0.7275 mL | 1.8187 mL | |
| 15 mM | 0.0485 mL | 0.2425 mL | 0.4850 mL | 1.2125 mL | |
| 20 mM | 0.0364 mL | 0.1819 mL | 0.3637 mL | 0.9094 mL | |
| 25 mM | 0.0291 mL | 0.1455 mL | 0.2910 mL | 0.7275 mL | |
| 30 mM | 0.0242 mL | 0.1212 mL | 0.2425 mL | 0.6062 mL | |
| 40 mM | 0.0182 mL | 0.0909 mL | 0.1819 mL | 0.4547 mL | |
| 50 mM | 0.0145 mL | 0.0727 mL | 0.1455 mL | 0.3637 mL | |
| 60 mM | 0.0121 mL | 0.0606 mL | 0.1212 mL | 0.3031 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
HLF1-11 Related Classifications
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