2. Apoptosis
  3. Apoptosis
  4. ANT1034

ANT1034 is humanized anti-CD52 antibody. ANT1034 directs antibody dependent and complement dependent cell cytotoxicity, induces Apoptosis when cross-linked or in the presence of a cross-linking antibody. ANT1034 leads to increased survival in a SCID CD52 tumour xenograft model. ANT1034 can be used for the research of B cell malignancies.

For research use only. We do not sell to patients.

ANT1034

ANT1034 Chemical Structure

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ANT1034 Related Antibodies

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Description

ANT1034 is humanized anti-CD52 antibody. ANT1034 directs antibody dependent and complement dependent cell cytotoxicity, induces Apoptosis when cross-linked or in the presence of a cross-linking antibody. ANT1034 leads to increased survival in a SCID CD52 tumour xenograft model. ANT1034 can be used for the research of B cell malignancies[1].

Species Reactivity

Human
IC50 & Target

CD52
In Vitro

ANT1034 (100 μg/ml; 72 hours) is more effective at directly inducing cell death (apoptosis/necrosis) in REH++ cells than Alemtuzumab (HY-P9948) in the presence of a crosslinking antibody[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ANT1034 Related Antibodies
In Vivo

ANT1034 (1-10 mg/kg; i.p.; once daily on alternate days; 7 doses) enhances survival in female Fox Chase SCID mice with Raji Burkitt lymphoma xenograft[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fox Chase SCID mice (female, 8 per group, injected with 1×10⁶ Raji++ cells via tail-vein injection)[1]
Dosage: 1, 10 mg/kg
Administration: i.p.; once daily on alternate days; 7 doses
Result: Increased mouse survival compared to alemtuzumab at 10 mg/kg; Showed superior survival enhancement even at the lower 1 mg/kg dose relative to alemtuzumab
Gene ID

1043  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ANT1034 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ANT1034ANT 1034ANT-1034ApoptosisCD4? T cell proliferationRaji Burkitt lymphoma xenograftapoptosisb cell malignanciesSCID mouse/human CD52 tumour xenograft modelcomplement dependent cell cytotoxicityT cell proliferationREH++ cellscancerFox Chase SCID miceantibody dependent cell cytotoxicitycrosslinking antibodyhuman peripheral blood mononuclear cellsalemtuzumabCD52Inhibitorinhibitorinhibit

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