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Redaporfin (Synonyms: LUZ11; F2BMet)

Cat. No.: HY-17644
Handling Instructions

Redaporfin (LUZ11) acts as a potent photosensitizer. Redaporfin causes direct antineoplastic effects as well as indirect immune‐dependent destruction of malignant lesions.

For research use only. We do not sell to patients.

Redaporfin Chemical Structure

Redaporfin Chemical Structure

CAS No. : 1224104-08-8

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Description

Redaporfin (LUZ11) acts as a potent photosensitizer. Redaporfin causes direct antineoplastic effects as well as indirect immune‐dependent destruction of malignant lesions[1].

In Vitro

The combination photodynamic therapy (PDT) with Redaporfin (5μM) induces a reduction in the abundance of several Golgi apparatus (GA) proteins such as Golgi brefeldin A-resistant guanine nucleotide exchange factor 1 (GBF1), golgin subfamily A member 2 (GOLGA2), and galactosyltransferase 1 (GALT1), as well as that of two ER proteins, eukaryotic translation initiation factor 2-alpha (eIF2α) kinase 3 (EIF2AK3) and protein disulfide-isomerase A3 (PDIA3). In contrast, there is no major decrease in mitochondrial import receptor subunit TOM20 homolog (TOMM20) or in the cytoskeleton protein β-actin[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Human osteosarcoma U2OS cells
Concentration: 0.3, 0.6, 1.3, 2.5, 5, 10 μM
Incubation Time: 6 hours
Result: Induced a reduction in the abundance of GBF1, GOLGA2, and GALT1, as well as EIF2AK3 and PDIA3.
Molecular Weight

1135.11

Formula

C₄₈H₃₈F₈N₈O₈S₄

CAS No.
SMILES

O=S(C1=CC=C(F)C(/C2=C3CCC(/C(C4=C(F)C(S(=O)(NC)=O)=CC=C4F)=C5C=C/C(N/5)=C(C6=C(F)C(S(=O)(NC)=O)=CC=C6F)/C(CC/7)=NC7=C(C8=C(F)C(S(=O)(NC)=O)=CC=C8F)/C9=CC=C2N9)=N\3)=C1F)(NC)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

RedaporfinLUZ11 F2BMetLUZ 11LUZ-11OthersPhotodynamictherapyendoplasmicreticulumGolgiInhibitorinhibitorinhibit

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Redaporfin
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HY-17644
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