PF-08046054
Based on 1 Customer Validation
PF-08046054 (SGN-PDL1V) is an antibody-drug conjugate (ADC) targeting PD-L1, formed by conjugating an anti-PD-L1 antibody with the vedotin drug linker VcMMAE (HY-15575). PF-08046054 exerts direct cytotoxicity against PD-L1-expressing tumor cells through intracellular delivery of MMAE. PF-08046054 can be used for research on solid tumors.
For research use only. We do not sell to patients.
- Purity : 97.41%
- Molecular Weight:150166 (average)
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Storage:Shipping with dry ice
-80°C, protect from light
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Chemical Information
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Appearance Liquid
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Molecular Weight 150166 (average)
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Color Colorless to light yellow
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SMILES
[PF-08046054]
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Synonyms
SGN-PDL1V
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Shipping
Shipping with dry ice.
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Storage
-80°C, protect from light
Purity & Documentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PF-08046054 Related Classifications
HY-171821 Related Classifications
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Keywords
- PF-08046054
- SGN-PDL1V
- PF08046054
- PF 08046054
- Antibody-Drug Conjugates (ADCs)
- PD-1/PD-L1
- Microtubule/Tubulin
- Antibody-Drug Conjugates
- ADC
- PD-1/Programmed death-ligand 1
- PD-1/PD-L1 immune checkpoint
- non-human primates
- non-small cell lung cancer
- PD-L1
- microtubule
- xenograft tumor models
- solid tumors
- head and neck squamous cell carcinoma
- MMAE
- PD-L1-expressing tumor cells
- Inhibitor
- inhibitor
- inhibit