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0990CL 

Cat. No.: HY-102076
Handling Instructions

0990CL is a specific heterotrimeric Gαi subunit inhibitor by direct interaction with Gαi. 0990CL is able to block α2AR mediated regulation of cAMP.

For research use only. We do not sell to patients.

0990CL Chemical Structure

0990CL Chemical Structure

CAS No. : 511514-03-7

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Description

0990CL is a specific heterotrimeric Gαi subunit inhibitor by direct interaction with Gαi. 0990CL is able to block α2AR mediated regulation of cAMP[1].

IC50 & Target

IC50: Gαi subunit[1]

In Vitro

0990CL (100 nM-1 μM; 24 hours) is able to restore α2AR/Gαi mediated cAMP levels elicited by Fsk and UK14304 in HEK293 GloSensor cells. When the dosage is at 100 nM, it restores 31% of the reduction of cAMP[1].
0990CL (30 μM; pre-treatment 30mins) shows selectivity for Gαi1 over Gαq. It demonstrates selectivity for Gαi and Gαq and results in a maximum endpoint fluorescence reduction of 38±8% and 10%, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

343.42

Formula

C₂₁H₂₁N₅

CAS No.

511514-03-7

SMILES

CC1(C)C=C(C)N=C(NC2=NC(C3=CC=CC=C3)=C4C=CC=CC4=N2)N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

0990CLOthersα2ARGαiHEK293heterotrimericG-proteinNMRInhibitorinhibitorinhibit

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0990CL
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