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Antibiotic inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (922) 11β-HSD (1) 5-HT Receptor (2) Acetyl-CoA Carboxylase (1) Acyltransferase (1) ADC Payload (15) Adenosine Deaminase (1) Akt (21) Aminoacyl-tRNA Synthetase (8) Aminopeptidase (2) Aminotransferases (Transaminases) (1) AMPK (5) Amyloid-β (1) Androgen Receptor (2) Angiotensin-converting Enzyme (ACE) (1) Antifolate (12) AP-1 (3) Apoptosis (122) Arginase (2) Atg8/LC3 (1) ATP Synthase (5) Aurora Kinase (8) Autophagy (42) Bacterial (892) Bcl-2 Family (11) Beta-lactamase (48) Btk (1) c-Myc (1) Cadherin (2) Calcium Channel (9) CaMK (1) Carbonic Anhydrase (4) Caspase (19) Cathepsin (1) CDK (1) CGRP Receptor (1) Claudin (2) COX (4) CRM1 (1) Cytochrome P450 (6) Dengue Virus (2) Deubiquitinase (2) Dihydrofolate reductase (DHFR) (6) Dipeptidyl Peptidase (3) DNA Alkylator/Crosslinker (2) DNA Methyltransferase (2) DNA/RNA Synthesis (118) Dopamine Receptor (2) Drug Derivative (3) Drug Intermediate (1) Drug Metabolite (12) Dynamin (2) E1/E2/E3 Enzyme (1) EAAT (5) EBV (2) Elastase (2) Endogenous Metabolite (39) Endothelin Receptor (1) Enolase (2) Environmental Pollutants (16) ERK (4) Estrogen Receptor/ERR (1) Exosomes (5) Farnesyl Transferase (2) Ferroptosis (3) Flavivirus (4) Fluorescent Dye (3) FOXO (2) Fungal (123) FXR (8) G protein-coupled Bile Acid Receptor 1 (8) GABA Receptor (8) Glutathione S-transferase (1) Glycosidase (1) GSK-3 (8) HBV (3) HCV (1) Herbicide (2) Hexokinase (1) HIF/HIF Prolyl-Hydroxylase (8) Histamine Receptor (7) Histone Demethylase (2) HIV (9) HIV Integrase (2) HIV Protease (1) HMG-CoA Reductase (HMGCR) (2) HSP (6) HSV (17) iGluR (1) Influenza Virus (12) Interleukin Related (16) Isotope-Labeled Compounds (81) JNK (8) Lactate Dehydrogenase (1) Liposome (1) LPL Receptor (8) MDM-2/p53 (19) Microtubule/Tubulin (3) Mitochondrial Metabolism (17) Mitophagy (11) MMP (15) Molecular Glues (1) mRNA (1) mTOR (7) Myosin (1) Na+/H+ Exchanger (NHE) (3) Na+/K+ ATPase (2) NADH Dehydrogenase (1) Necroptosis (3) NF-κB (14) NO Synthase (7) NOD-like Receptor (NLR) (3) Nuclear Factor of activated T Cells (NFAT) (1) Nuclear Hormone Receptor 4A/NR4A (1) Nucleoside Antimetabolite/Analog (3) Orthopoxvirus (17) Oxidative Phosphorylation (8) P-glycoprotein (11) p38 MAPK (6) Parasite (100) PARP (1) PDI (3) Penicillin-binding protein (PBP) (25) PGC-1α (1) Phosphatase (3) Phospholipase (7) PI3K (17) PINK1/Parkin (2) PKC (2) Potassium Channel (8) PPAR (3) Prolyl Endopeptidase (PREP) (1) Prostaglandin Receptor (2) Proteasome (5) Protein Arginine Deiminase (1) Proton Pump (5) PTEN (2) Pyroptosis (3) Pyruvate Kinase (1) Ras (2) Reactive Oxygen Species (ROS) (36) Reference Standards (198) S-adenosylhomocysteine hydrolase (SAHH) (1) SARS-CoV (5) SOD (1) Src (1) STAT (7) TAM Receptor (1) TGF-beta/Smad (1) TGF-β Receptor (2) Thymidylate Synthase (1) Tie (2) TNF Receptor (9) Toll-like Receptor (TLR) (1) Topoisomerase (97) TRP Channel (1) Tyrosinase (6) Wnt (7) YAP (1) α-synuclein (2) β-catenin (8)
By Research Areas:	Cancer (332) Cardiovascular Disease (32) Endocrinology (12) Infection (1002) Inflammation/Immunology (147) Metabolic Disease (40) Neurological Disease (57)
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1087

Inhibitors & Agonists

Screening-Bibliotheken

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

MCE-Kits

Inhibitory Antibodies

376

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

GMP Molecules

Targets Recommended: Antibiotic

Art. -Nr.	Produktname	Target	Forschungsgebiete	Chemical Structure

HY-B1743A

Puromycin dihydrochloride 385+ Cited Publications CL13900 dihydrochloride	Bacterial Antibiotic Parasite	Infection Cancer
Puromycin dihydrochloride (CL13900 dihydrochloride), an aminonucleoside antibiotic, inhibits protein synthesis .

HY-17565A

Bleomycin hydrochloride 190+ Cited Publications	DNA/RNA Synthesis Antibiotic	Cancer
Bleomycin hydrochloride is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin hydrochloride is an antitumor antibiotic .

HY-17565

Bleomycin sulfate 190+ Cited Publications Bleomycin sulfate	DNA/RNA Synthesis Antibiotic	Cancer
Bleomycin sulfate is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin sulfate is an antitumor antibiotic .

HY-B1743

Puromycin 385+ Cited Publications CL13900	Bacterial Antibiotic Parasite	Infection
Puromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis.

HY-N1724

Concanamycin A 25+ Cited Publications Antibiotic X 4357B; Folimycin; X 4357B	Proton Pump Bacterial Antibiotic	Infection Inflammation/Immunology Cancer
Concanamycin A (Folimycin; Antibiotic X 4357B) is a macrolide *antibiotic, a vacuolar type H ⁺-ATPase (V-ATPase)* inhibitor. Concanamycin A is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research ^- .

HY-10394

Linezolid 50+ Cited Publications PNU-100766	Bacterial Antibiotic	Infection Cancer
Linezolid (PNU-100766) is the first member of the class of oxazolidinone synthetic antibiotic. Linezolid acts by inhibiting the initiation of bacterial protein synthesis. Linezolid is used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics .

HY-A0256

Clavulanic acid 5+ Cited Publications	Beta-lactamase Antibiotic Bacterial	Infection Inflammation/Immunology
Clavulanic acid is a naturally occurring powerful bacterial β-lactamases inhibitor for research of infections caused by bacteria, including infections of the ears. Clavulanic acid is active against a wide spectrum of gram-positive and gram-negative bacterias .

HY-B1329

Apramycin sulfate 4 Publications Verification Nebramycin II sulfate	Bacterial Antibiotic	Infection
Apramycin (EBL 1003) sulfate is an orally active, acidic pH tolerant and aminoglycoside-modifying-enzymes-tolerant aminoglycoside *antibiotic* which inhibits protein biosynthesis by targeting the bacterial ribosome. Apramycin sulfate is a potential anti-drug-resistance antibiotic .

HY-19609

Calicheamicin 10+ Cited Publications Calicheamicin γ1	DNA Alkylator/Crosslinker ADC Payload Bacterial Apoptosis Antibiotic	Infection Cancer
Calicheamicin, an antitumor antibiotic, is a cytotoxic agent that causes double-strand DNA breaks. Calicheamicin is a DNA synthesis inhibitor .

HY-B0472

Streptomycin sulfate 45+ Cited Publications	Environmental Pollutants Antibiotic Bacterial	Infection
Streptomycin sulfate is an aminoglycoside antibiotic, that inhibits protein synthesis.

HY-B0974

Methicillin sodium salt 5+ Cited Publications Meticillin sodium	Penicillin-binding protein (PBP) Bacterial Antibiotic	Infection
Methicillin sodium salt (Meticillin sodium) is a β-lactam, semi-synthetic antibiotic related to penicillin antibiotic. Methicillin sodium salt inhibits penicillin-binding proteins involved in the synthesis of peptidoglycan. Methicillin sodium salt inhibits S. aureus with a MIC value of 2.1 μg/mL. Methicillin sodium salt can be used for the research of inflammation .

HY-17025

Rifabutin 5+ Cited Publications Ansamycin; LM-427	DNA/RNA Synthesis Bacterial Antibiotic	Infection
Rifabutin (Ansamycin) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits DNA-dependent RNA polymerase.

HY-B0408A

Clindamycin hydrochloride 10+ Cited Publications	Bacterial Antibiotic	Infection Cancer
Clindamycin (hydrochloride) is a semisynthetic lincosamide antibiotic, which inhibits protein synthesis by acting on the 50S ribosomal.

HY-B1327

Chlortetracycline hydrochloride 5+ Cited Publications 7-Chlorotetracycline hydrochloride	Bacterial Antibiotic Parasite	Infection Inflammation/Immunology
Chlortetracycline hydrochloride (7-Chlorotetracycline hydrochloride) is an orally active, effective and selectively methanogenic bacteria inhibitor with bactericidal effects. Chlortetracycline hydrochloride is also a *antibiotic* that acts by inhibiting bacterial protein synthesis. Additionally, Chlortetracycline hydrochloride is a specific and potent calcium ionophore *antibiotic, inhibiting* binding of aminoacyl-tRNA to ribosomes .

HY-15739

Ansamitocin P-3 5+ Cited Publications Antibiotic C 15003P3; Maytansinol isobutyrate	Microtubule/Tubulin ADC Payload Bacterial Antibiotic	Infection Cancer
Ansamitocin P-3 (Antibiotic C 15003P3) is a microtubule inhibitor. Ansamitocin P-3 is a macrocyclic antitumor antibiotic.

HY-A0256A

Clavulanate potassium 5+ Cited Publications	Beta-lactamase Bacterial Antibiotic	Infection
Clavulanate potassium is a potent β-lactamase inhibitor and acts as an antibiotic .

HY-B0555A

Nafcillin sodium monohydrate 2 Publications Verification	Beta-lactamase Bacterial Antibiotic	Infection
Nafcillin sodium monohydrate, an antibiotic, is a reversible inhibitor of β-lactamase. Nafcillin sodium monohydrate can be used for the research of staphylococcal infections .

HY-A0256B

Clavulanate lithium 5+ Cited Publications	Beta-lactamase Bacterial Antibiotic	Infection
Clavulanate lithium is a potent β-lactamase inhibitor and acts as an antibiotic .

HY-13725

Pirarubicin 25+ Cited Publications THP	Topoisomerase Autophagy Bacterial Antibiotic	Infection Cancer
Pirarubicin is an anthracycline antibiotics, acts as a topoisomerase II inhibitor, and is a widely used for treatment of various cancers, in particular, solid tumors.

HY-13725A

Pirarubicin Hydrochloride 25+ Cited Publications THP Hydrochloride	Topoisomerase Autophagy Bacterial Antibiotic	Infection Cancer
Pirarubicin Hydrochloride is an anthracycline antibiotics, acts as a topoisomerase II inhibitor, and is a widely used for treatment of various cancers, in particular, solid tumors.

HY-B0526

Flumequine 3 Publications Verification R-802	Bacterial Topoisomerase Antibiotic	Infection Cancer
Flumequine (R-802) is a quinolone antibiotic, and acts as a topoisomerase II inhibitor, with an IC₅₀ of 15 μM (3.92 μg/mL).

HY-P3884

Arylomycin A2	Bacterial Antibiotic	Infection
Arylomycin A2, an *antibiotic* (Antibiotic), is a lipopeptide type I signal peptidase (SPase I) inhibitor. Arylomycin A2 has antibacterial effects .

HY-117778

SF2312	Enolase Bacterial Antibiotic	Infection Cancer
SF2312, a natural phosphonate *antibiotic* (Antibiotic), is a highly potent Enolase inhibitor with IC₅₀s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively. SF2312 is active against bacteria under anaerobic conditions .

HY-B1327A

Chlortetracycline 7-Chlorotetracycline	Bacterial Antibiotic Parasite	Infection Inflammation/Immunology
Chlortetracycline (7-Chlorotetracycline) is an orally active, effective and selectively methanogenic bacteria inhibitor with bactericidal effects. Chlortetracycline is also a *antibiotic* that acts by inhibiting bacterial protein synthesis. Additionally, Chlortetracycline is a specific and potent calcium ionophore *antibiotic, inhibiting* binding of aminoacyl-tRNA to ribosomes .

HY-112639

Aristeromycin	Antibiotic Bacterial S-adenosylhomocysteine hydrolase (SAHH)	Infection Cancer
Aristeromycin, an adenosine analog, is an antibiotic and a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor .

HY-13588

Cefsulodin sodium SCE-129 sodium	Bacterial Antibiotic	Infection
Cefsulodin (SCE-129) sodium is a third generation β lactam antibiotic and member of the cephems subgroup of antibiotics. Cefsulodin sodium inhibits cell wall synthesis by competitively inhibiting penicillin binding protein (PBP) cross-linking and transpeptidation of peptidogly. Cefsulodin sodium is a potent tyrosine phosphatase inhibitor against mPTPB, a virulent phosphatase from Mycobacterium tuberculosis, with an IC₅₀ value of 16 μM .

HY-12820

Sibofimloc 4 Publications Verification Antibiotic-202	Bacterial Antibiotic	Infection
Sibofimloc (Antibiotic-202) is a first-in-class, gut-restricted, orally active FimH adhesion inhibitor extracted from patent WO2014100158A1, Compound Example 202. Sibofimloc has anti-bacterial infective activity. Sibofimloc is developed for inflammatory bowel disease (IBD) .

HY-W561907

IMipenem and cilastatin sodium	Antibiotic Bacterial	Infection
IMipenem and cilastatin sodium is a broad-spectrum Carbapenem *Antibiotic* combination. Imipenem (HY-B1369A) is a Carbapenem antibiotic. IMipenem demonstrates excellent activity against gram-positive and gram-negative aerobic and anaerobic organisms. Cilastatin (HY-A0166) is a renal Dehydropeptidase inhibitor that inhibits the metabolism of Imipenem by renal brush-border enzymes, thus increasing imipenem concentrations in urine .

HY-B1434

7-Aminocephalosporanic acid 2 Publications Verification 7-ACA	Beta-lactamase Bacterial Antibiotic	Infection
7-aminocephalosporanic acid (7-ACA) is a HSP90β inhibitor and an *antibiotic. 7-Aminocephalosporanic acid is the core chemical structure of the synthesis of cephalosporin antibiotics* and an effective β-lactamase inhibitor .

HY-119764

Ikarugamycin 2 Publications Verification	Antibiotic	Others
Ikarugamycin is an antibiotic and a inhibitor of clathrin-mediated endocytosis (CME) .

HY-N10495

Seconeolitsine	Antibiotic Bacterial Topoisomerase	Infection
Seconeolitsine, an antibiotic, and is an inhibitor of targeting topoisomerase I (TopA). Seconeolitsine also is a new antimicrobial agent that can inhibit S. pneumoniae growth. Seconeolitsine can inhibit TopA relaxation activity with an IC₅₀ value of 17 μM. Seconeolitsine can be used for the research of S. pneumoniae infections resistant to other antibiotics .

HY-136461

Polyoxin D Polyoxorim	Antibiotic Fungal	Infection
Polyoxin D (Polyoxorim), a polyoxin antibiotic fungicide, is a potent chitin synthetase inhibitor .

HY-N11422

Mycaminosyltylonolide	Antibiotic Bacterial	Infection
Mycaminosyltylonolide is a potent antibiotic. Mycaminosyltylonolide shows antibacterial activity. Mycaminosyltylonolide inhibits luciferase synthesis .

HY-B1743S

Puromycin-d3 3 Publications Verification CL13900-d₃	Isotope-Labeled Compounds Bacterial Antibiotic	Infection
Puromycin-d₃ is the deuterium labeled Puromycin. Puromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis.

HY-122386

Kirromycin Mocimycin; Delvomycin	Bacterial Antibiotic	Infection
Kirromycin (Mocimycin; Delvomycin) is an elongation factor Tu (EF-Tu) inhibitor targeting protein biosynthesis. As an *antibiotic, Kirromycin exerts antibacterial activity against Gram-negative bacteria* by acting on EF-Tu to interfere with the peptidyl transfer reaction. Kirromycin is applicable to studies on bacterial infections .

HY-107767

Antibiotic DC 81 DC 81	Antibiotic Apoptosis DNA/RNA Synthesis	Cancer
Antibiotic DC 81 (DC 81), an antitumor antibiotic produced by Streptomyces species, is a PBD (pyrrolo[2,1-c][1,4]benzodiazepine). Antibiotic DC 81 is potent inhibitor of nucleic acid synthesis. Antibiotic DC 81 can recognize and bind to specific sequences of DNA and form a labile covalent adduct .

HY-106257A

Ceftolozane TFA 2 Publications Verification	Antibiotic Bacterial	Infection
Ceftolozane TFA is a cephalosporin *antibiotic* that can be used to inhibit Gram-negative bacterial infections. Ceftolozane TFA can be used to synthesize new *antibiotic* that are more potent and safer .

HY-119759A

Lipoxamycin hemisulfate	Antibiotic Fungal	Infection
Lipoxamycin hemisulfate is an antifungal antibiotic and a potent serine palmitoyltransferase inhibitor with an IC₅₀ of 21 nM .

HY-N7111

Sultamicillin tosylate Sultamicillin (tosilate)	Bacterial Antibiotic	Infection
Sultamicillin tosylate is a broad-spectrum and orally active beta-lactamase inhibitor, an *antibiotic* with antibacterial activity .

HY-N7115

Sultamicillin	Bacterial Antibiotic	Infection
Sultamicillin is a broad-spectrum and orally active beta-lactamase inhibitor, an *antibiotic* with antibacterial activity .

HY-121482

(+)-Ochromycinone STA-21	STAT	Inflammation/Immunology Cancer
(+)-Ochromycinone is a natural antibiotic that potently inhibits STAT3. (+)-Ochromycinone is used in the researches of cancers and psoriasis .

HY-106257S

Ceftolozane-d6 TFA	Isotope-Labeled Compounds Antibiotic Bacterial	Infection
Ceftolozane-d₆ TFA is a deuterated labeled Ceftolozane TFA (HY-106257A). Ceftolozane TFA is a cephalosporin antibiotic that can be used to inhibit Gram-negative bacterial infections. Ceftolozane TFA can be used to synthesize new antibiotic that are more potent and safer .

HY-18982R

Anisomycin (Standard) Flagecidin (Standard); Wuningmeisu C (Standard)	Reference Standards DNA/RNA Synthesis JNK Bacterial Apoptosis Antibiotic Parasite	Infection Cancer
Anisomycin (Standard) is the analytical standard of Anisomycin. This product is intended for research and analytical applications. Anisomycin is a potent protein synthesis inhibitor which interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system[1]. Anisomycin is a JNK activator, which increases phospho-JNK[2][3]. Anisomycin is a bacterial antibiotic[4].

HY-N6737

Aureothricin	Bacterial Antibiotic	Infection
Aureothricin is a dithiolopyrrolone (DTP) antibiotic first isolated from Streptomyces and exhibits relatively broad-spectrum antibiotic activity. Aureothricin can inhibit adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin .

HY-106702A

Fostriecin PD 110161; CL 1565A; CI-920	Antibiotic Bacterial Topoisomerase Phosphatase	Infection
Fostriecin is a triene *antibiotic. Fostriecin is a topoisomerase II* and protein phosphatase PP2A inhibitor .

HY-139628

JPD447	Bacterial	Infection Cancer
JPD447, a MAC-0547630 derivative, is a novel class of UppS inhibitor to potentiate β-lactam antibiotics.

HY-P5459

Elafin(human)	Bacterial Elastase	Infection
Elafin,also known as elafin-specific inhibitor (ESI) or skin anti-leucoprotease (SKALP), is a low molecular weight inhibitor of human neutrophil elastase (HNE) and proteinase 3 in lung. Elafin is *antibiotic* against Pseudomonas aeruginosa and Staphylococcus aureus .

HY-17558

Apramycin 4 Publications Verification Nebramycin II	Bacterial Antibiotic	Infection
Apramycin (Nebramycin II) is an orally active, acidic pH tolerant and aminoglycoside-modifying-enzymes-tolerant aminoglycoside *antibiotic* which inhibits protein biosynthesis by targeting the bacterial ribosome. Apramycin is a potential anti-drug-resistance antibiotic .

HY-152965

Biotin-doxorubicin	Topoisomerase Antibiotic Apoptosis Autophagy	Infection Cancer
Biotin-doxorubicin is a Biotin-labeled Doxorubicin. Doxorubicin, a broad-spectrum anthracycline *antibiotic, is a topoisomerase II* inhibitor .

HY-B0555B

Nafcillin sodium	Beta-lactamase Antibiotic Bacterial	Infection
Nafcillin sodium, an antibiotic, is a reversible inhibitor of β-lactamase. Nafcillin sodium can be used for the research of staphylococcal infections .

Art. -Nr.	Produktname	Category	Target	Chemical Structure

HY-B1743A

Puromycin dihydrochloride 385+ Cited Publications CL13900 dihydrochloride	Infection Microorganisms Classification of Application Fields Antibiotics Resistance Selection Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial Antibiotic Parasite
Puromycin dihydrochloride (CL13900 dihydrochloride), an aminonucleoside antibiotic, inhibits protein synthesis .

HY-17565

Bleomycin sulfate 190+ Cited Publications Bleomycin sulfate	Microorganisms Classification of Application Fields Antibiotics Resistance Selection Mammalian Cell Culture Disease Research Anticancer Disease Research Fields Other Antibiotics Source Classification Cancer	DNA/RNA Synthesis Antibiotic
Bleomycin sulfate is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin sulfate is an antitumor antibiotic .

HY-B1743

Puromycin 385+ Cited Publications CL13900	Infection Structural Classification Alkaloids Microorganisms Classification of Application Fields Other Alkaloids Disease Research Fields Source Classification	Bacterial Antibiotic Parasite
Puromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis.

HY-17362

Vancomycin hydrochloride Maximum Cited Publications 94 Publications Verification	Plant Cell Culture Microorganisms Classification of Application Fields Antibiotics Phenols Polyphenols Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification Cancer	Bacterial Autophagy Antibiotic
Vancomycin hydrochloride is an antibiotic for the treatment of bacterial infections. It acts by inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin also alters the permeability of the cell membrane and selectively inhibits ribonucleic acid synthesis.

HY-N6782

Oligomycin 100+ Cited Publications	Infection Microorganisms Antifungal Macrolide Antibiotics Classification of Application Fields Antibiotics Disease Research Anticancer Disease Research Fields Source Classification	Oxidative Phosphorylation ATP Synthase Fungal Antibiotic
Oligomycin, an antifungal antibiotic, is an inhibitor of H ⁺-ATP-synthase. Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells .

HY-18258

Berberine chloride 75+ Cited Publications Natural Yellow 18 chloride	Alkaloids Phellodendron amurense Rupr. Classification of Application Fields Rutaceae Plants Isoquinoline Alkaloids Disease Research Fields Biological Pesticide Research Source Classification Cancer Agricultural Research	Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Antibiotic Endogenous Metabolite Parasite
Berberine chloride is an alkaloid that acts as an *antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits* DNA topoisomerase. Antineoplastic properties .

HY-A0276

Gentamicin sulfate 60+ Cited Publications	Structural Classification Classification of Application Fields Antibacterial Disease Research Other Antibiotics Plant agriculture research Infection Plant Cell Culture Microorganisms Antibiotics Resistance Selection Animal Husbandry Mammalian Cell Culture Disease Research Fields Source Classification	Environmental Pollutants Antibiotic Bacterial
Gentamicin sulfate, an aminoglycoside antibiotic, inhibits the growth of both gram-positive and gram-negative bacteria and to inhibit several strains of mycoplasma in tissue culture. Gentamicin sulfate inhibits DNase I with an IC₅₀ of 0.57 mM .

HY-N1724

Concanamycin A 25+ Cited Publications Antibiotic X 4357B; Folimycin; X 4357B	Infection Natürliche Produkte Microorganisms Classification of Application Fields Disease Research Fields Source Classification	Proton Pump Bacterial Antibiotic
Concanamycin A (Folimycin; Antibiotic X 4357B) is a macrolide *antibiotic, a vacuolar type H ⁺-ATPase (V-ATPase)* inhibitor. Concanamycin A is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research ^- .

HY-A0089

Colistin sulfate 25+ Cited Publications Polymyxin E sulfate	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Animal Husbandry Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial Autophagy Antibiotic
Colistin sulfate is a polypeptide antibiotic which inhibits gram-negative bacteria by binding to lipopolysaccharides and phospholipids in the outer cell membrane of gram-negative bacteria.

HY-B1329

Apramycin sulfate 4 Publications Verification Nebramycin II sulfate	Microorganisms Classification of Application Fields Antibiotics Animal Husbandry Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification Cancer	Bacterial Antibiotic
Apramycin (EBL 1003) sulfate is an orally active, acidic pH tolerant and aminoglycoside-modifying-enzymes-tolerant aminoglycoside *antibiotic* which inhibits protein biosynthesis by targeting the bacterial ribosome. Apramycin sulfate is a potential anti-drug-resistance antibiotic .

HY-107193

Bacitracin 3 Publications Verification	Structural Classification Classification of Application Fields Anti-aging Anti-parasitic Antibacterial Disease Research Other Antibiotics Infection Plant Cell Culture Microorganisms Antibiotics Resistance Selection Disease Research Fields Source Classification Cancer	Environmental Pollutants Antibiotic Bacterial PDI
Bacitracin is a polypeptide *antibiotic* against staphylococcal and pathogenic protozoa infections. Bacitracin inhibits cell wall biosynthesis and permeability through binding to the undecaprenyl pyrophosphate. Bacitracin inhibits macromolecular synthesis. Bacitracin is also a protein disulfide isomerase (PDI) inhibitor .

HY-B0472

Streptomycin sulfate 45+ Cited Publications	Structural Classification Classification of Application Fields Antibacterial Disease Research Other Antibiotics Plant agriculture research Infection Plant Cell Culture Microorganisms Antibiotics Resistance Selection Disease Research Fields Source Classification	Environmental Pollutants Antibiotic Bacterial
Streptomycin sulfate is an aminoglycoside antibiotic, that inhibits protein synthesis.

HY-17577

Berberine chloride hydrate 70+ Cited Publications Natural Yellow 18 chloride hydrate	Alkaloids Classification of Application Fields Coptis chinensis Franch. Ranunculaceae Plants Isoquinoline Alkaloids Disease Research Fields Source Classification Cancer	Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Antibiotic Endogenous Metabolite Parasite
Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid that acts as an *antibiotic. Berberine chloride hydrate induces reactive oxygen species (ROS) generation and inhibits* DNA topoisomerase. Antineoplastic properties .

HY-B1327

Chlortetracycline hydrochloride 5+ Cited Publications 7-Chlorotetracycline hydrochloride	Structural Classification Classification of Application Fields Antibacterial Disease Research Other Antibiotics Plant agriculture research Infection Monophenols Microorganisms Antibiotics Resistance Selection Animal Husbandry Phenols Disease Research Fields Source Classification	Bacterial Antibiotic Parasite
Chlortetracycline hydrochloride (7-Chlorotetracycline hydrochloride) is an orally active, effective and selectively methanogenic bacteria inhibitor with bactericidal effects. Chlortetracycline hydrochloride is also a *antibiotic* that acts by inhibiting bacterial protein synthesis. Additionally, Chlortetracycline hydrochloride is a specific and potent calcium ionophore *antibiotic, inhibiting* binding of aminoacyl-tRNA to ribosomes .

HY-15739

Ansamitocin P-3 5+ Cited Publications Antibiotic C 15003P3; Maytansinol isobutyrate	Infection Microorganisms Classification of Application Fields Antibiotics Disease Research Anticancer Disease Research Fields Other Antibiotics Source Classification	Microtubule/Tubulin ADC Payload Bacterial Antibiotic
Ansamitocin P-3 (Antibiotic C 15003P3) is a microtubule inhibitor. Ansamitocin P-3 is a macrocyclic antitumor antibiotic.

HY-P1975

Aureobasidin A 3 Publications Verification Basifungin	Infection Microorganisms Antifungal Classification of Application Fields Antibiotics Disease Research Inflammation/Immunology Disease Research Fields Other Antibiotics Source Classification	Antibiotic Fungal Parasite
Aureobasidin A (Basifungin) is a cyclic peptide antibiotic with oral activity. Aureobasidin A is an inhibitor of inositol phosphorylated ceramide synthetase AUR1. Aureobasidin A has antifungal and antiparasitic activity .

HY-B1418

Tazobactam 15+ Cited Publications CL-298741; YTR-830H	Infection Microorganisms Anti-inflammation/Immunoregulatory Classification of Application Fields Antibiotics Resistance Selection Antibacterial Disease Research Disease Research Fields Beta-lactam Antibiotics Source Classification	Beta-lactamase Antibiotic Bacterial
Tazobactam (CL-298741) is a potent β-lactamases inhibitor and penicillin antibiotic. Tazobactam has antibacterial activity. Tazobactam can be used for pneumonia research .

HY-B0132

Norfloxacin 5 Publications Verification MK-0366	Infection Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Bacterial Endogenous Metabolite Antibiotic
Norfloxacin (MK-0366) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase.

HY-112177

Myxothiazol	Infection Microorganisms Antifungal Classification of Application Fields Antibiotics Disease Research Disease Research Fields Other Antibiotics Source Classification	Fungal Mitochondrial Metabolism Antibiotic
Myxothiazol, an antifungal antibiotic, is a mitochondrial electron transport chain complex III (bc1 complex) inhibitor. Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml .

HY-117778

SF2312	Natürliche Produkte Microorganisms Source Classification	Enolase Bacterial Antibiotic
SF2312, a natural phosphonate *antibiotic* (Antibiotic), is a highly potent Enolase inhibitor with IC₅₀s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively. SF2312 is active against bacteria under anaerobic conditions .

HY-112639

Aristeromycin	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Antibiotic Bacterial S-adenosylhomocysteine hydrolase (SAHH)
Aristeromycin, an adenosine analog, is an antibiotic and a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor .

HY-100528

Nanchangmycin 3 Publications Verification Nanchangmycin A	Infection Microorganisms Classification of Application Fields Antibiotics Antiviral Antibacterial Disease Research Disease Research Fields Polyether Antibiotics Source Classification	Bacterial Antibiotic Flavivirus
Nanchangmycin, a polyether antibiotic produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria . Nanchangmycin is a broad spectrum antiviral active against Zika virus .

HY-142127

Ribostamycin 1 Publications Verification Vistamycin; SF-733	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial Antibiotic PDI
Ribostamycin (Vistamycin) is a broad-spectrum aminoglycoside *antibiotic. Ribostamycin is effective against Gram-Negative and Gram-Positive bacterial infection. Ribostamycin also inhibits* the chaperone activity of PDI .

HY-B1434

7-Aminocephalosporanic acid 2 Publications Verification 7-ACA	Infection Classification of Application Fields Disease Research Fields	Beta-lactamase Bacterial Antibiotic
7-aminocephalosporanic acid (7-ACA) is a HSP90β inhibitor and an *antibiotic. 7-Aminocephalosporanic acid is the core chemical structure of the synthesis of cephalosporin antibiotics* and an effective β-lactamase inhibitor .

HY-119764

Ikarugamycin 2 Publications Verification	Microorganisms Classification of Application Fields Antibiotics Other Diseases Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Antibiotic
Ikarugamycin is an antibiotic and a inhibitor of clathrin-mediated endocytosis (CME) .

HY-N7151

Aurachin D	Structural Classification Alkaloids Microorganisms Quinoline Alkaloids Source Classification	Antibiotic Bacterial Fungal
Aurachin D is an *antibiotic. Aurachin D inhibits* Gram-positive bacteria and a few funguses. Aurachin D blocks NADH oxidation in beef heart submitochondrial particles .

HY-18061

Ochromycinone 3 Publications Verification (Rac)-STA-21	Infection Quinones Monophenols Microorganisms Classification of Application Fields Anthraquinones Phenols Disease Research Fields Source Classification	Antibiotic STAT Bacterial
Ochromycinone ((Rac)-STA-21) is a natural antibiotic and a STAT3 inhibitor. Ochromycinone can inhibits STAT3 DNA binding activity, STAT3 dimerization. Ochromycinone has anticancer and antimicrobial activity .

HY-A0279A

Pristinamycin IA 1 Publications Verification Mikamycin B; Mikamycin IA	Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Cyclopeptides Other Diseases Antibacterial Disease Research Disease Research Fields Source Classification	Bacterial Antibiotic
Pristinamycin IA (Mikamycin B) is a cycle-peptidic macrolactone *antibiotic. Pristinamycin IA is a substrate of P-glycoprotein* and inhibits its function. Pristinamycin IA is active against StaphyloEoccus and Srreptococcus .

HY-W013673

2,3-Diaminopropionic acid hydrochloride	Structural Classification Natürliche Produkte Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Tyrosinase
2,3-Diaminopropionic acid hydrochloride is the precursor of antibiotics and the siderophore staphyloferrin B. 2,3-Diaminopropionic acid hydrochloride is the inhibitor for polyphenoloxidase (PPO) .

HY-117260

Coformycin	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Anticancer Disease Research Fields Other Antibiotics Source Classification	Adenosine Deaminase Bacterial Antibiotic
Coformycin, a nucleoside antibiotic, is a potent inhibitor of adenosine deaminase (ADA) from Streptomyces species. Coformycin possesses anti-tumor and anti-bacterial activity .

HY-N10495

Seconeolitsine	Infection Microorganisms Classification of Application Fields Antibiotics Disease Research Fields Source Classification	Antibiotic Bacterial Topoisomerase
Seconeolitsine, an antibiotic, and is an inhibitor of targeting topoisomerase I (TopA). Seconeolitsine also is a new antimicrobial agent that can inhibit S. pneumoniae growth. Seconeolitsine can inhibit TopA relaxation activity with an IC₅₀ value of 17 μM. Seconeolitsine can be used for the research of S. pneumoniae infections resistant to other antibiotics .

HY-N11422

Mycaminosyltylonolide	Microorganisms Antibiotics Antibacterial Disease Research Source Classification	Antibiotic Bacterial
Mycaminosyltylonolide is a potent antibiotic. Mycaminosyltylonolide shows antibacterial activity. Mycaminosyltylonolide inhibits luciferase synthesis .

HY-122386

Kirromycin Mocimycin; Delvomycin	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial Antibiotic
Kirromycin (Mocimycin; Delvomycin) is an elongation factor Tu (EF-Tu) inhibitor targeting protein biosynthesis. As an *antibiotic, Kirromycin exerts antibacterial activity against Gram-negative bacteria* by acting on EF-Tu to interfere with the peptidyl transfer reaction. Kirromycin is applicable to studies on bacterial infections .

HY-N7111

Sultamicillin tosylate Sultamicillin (tosilate)	Infection Classification of Application Fields Disease Research Fields	Bacterial Antibiotic
Sultamicillin tosylate is a broad-spectrum and orally active beta-lactamase inhibitor, an *antibiotic* with antibacterial activity .

HY-18982R

Anisomycin (Standard) Flagecidin (Standard); Wuningmeisu C (Standard)	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Source Classification	Reference Standards DNA/RNA Synthesis JNK Bacterial Apoptosis Antibiotic Parasite
Anisomycin (Standard) is the analytical standard of Anisomycin. This product is intended for research and analytical applications. Anisomycin is a potent protein synthesis inhibitor which interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system[1]. Anisomycin is a JNK activator, which increases phospho-JNK[2][3]. Anisomycin is a bacterial antibiotic[4].

HY-B1743AR

Puromycin dihydrochloride (Standard) CL13900 dihydrochloride (Standard)	Structural Classification Microorganisms Antibiotics Resistance Selection Antibacterial Disease Research Other Antibiotics Source Classification	Reference Standards Bacterial Antibiotic Parasite
Puromycin (dihydrochloride) (Standard) is the analytical standard of Puromycin (dihydrochloride). This product is intended for research and analytical applications. Puromycin dihydrochloride (CL13900 dihydrochloride), an aminonucleoside antibiotic, inhibits protein synthesis .

HY-N6737

Aureothricin	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial Antibiotic
Aureothricin is a dithiolopyrrolone (DTP) antibiotic first isolated from Streptomyces and exhibits relatively broad-spectrum antibiotic activity. Aureothricin can inhibit adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin .

HY-106702A

Fostriecin PD 110161; CL 1565A; CI-920	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial Topoisomerase Phosphatase
Fostriecin is a triene *antibiotic. Fostriecin is a topoisomerase II* and protein phosphatase PP2A inhibitor .

HY-N13920

Avilamycin C	Natürliche Produkte Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Avilamycin C is an avilamycin-type antibiotic. Avilamycin C has antibacterial activity and can inhibit Gram-positive bacteria .

HY-B1329R

Apramycin sulfate (Standard) Nebramycin II sulfate (Standard)	Structural Classification Microorganisms Antibiotics Animal Husbandry Antibacterial Disease Research Other Antibiotics Source Classification	Reference Standards Bacterial Antibiotic
Apramycin (sulfate) (Standard) is the analytical standard of Apramycin (sulfate). This product is intended for research and analytical applications. Apramycin (EBL 1003) is an orally active, acidic pH tolerant and aminoglycoside-modifying-enzymes-tolerant aminoglycoside antibiotic which inhibits protein biosynthesis by targeting the bacterial ribosome. Apramycin is a potential anti-drug-resistance antibiotic .

HY-118593

A2315A Madumycin II; Antibiotic A 2315A	Structural Classification Natürliche Produkte Microorganisms Source Classification	Antibiotic
A2315A (Madumycin II) is an alanine-containing streptogramin A *antibiotic. A2315A is a potent peptidyl transferase center (PTC)* inhibitor. A2315A inhibits the ribosome prior to the first cycle of peptide bond formation .

HY-113379

2,3-Diaminopropionic acid	Classification of Application Fields Other Diseases Amino acids Endogenous metabolite Disease Research Fields Source Classification	Tyrosinase
2,3-Diaminopropionic acid is the precursor of antibiotics and the siderophore staphyloferrin B. 2,3-Diaminopropionic acid is the inhibitor for polyphenoloxidase (PPO) .

HY-N12201

Funiculosin	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Fungal
Funiculosin is a neutral lipophilic antibiotic that inhibits DNA and RNA viruses. Funiculosin also has antifungal activity. Funiculosin inhibits infections caused by pathogenic fungi in primary chicken embryo fibroblasts .

HY-B0472R

Streptomycin sulfate (Standard)	Structural Classification Plant Cell Culture Microorganisms Antibiotics Resistance Selection Antibacterial Disease Research Other Antibiotics Plant agriculture research Source Classification	Reference Standards Bacterial Antibiotic
Streptomycin (sulfate) (Standard) is the analytical standard of Streptomycin (sulfate). This product is intended for research and analytical applications. Streptomycin sulfate is an aminoglycoside antibiotic, that inhibits protein synthesis.

HY-119759

Lipoxamycin	Infection Microorganisms Antifungal Classification of Application Fields Antibiotics Disease Research Disease Research Fields Other Antibiotics Source Classification	Fungal
Lipoxamycin is an antifungal antibiotic and a potent serine palmitoyltransferase inhibitor with an IC₅₀ of 21 nM .

HY-100496

Nucleocidin 4'-Fluoro-5'-O-sulfamoyladenosine; NSC 521007	Infection Microorganisms Classification of Application Fields Antibiotics Anti-parasitic Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial
Nucleocidin is an antitrypanosomal antibiotic, inhibiting the transfer of labeled amino acid from S-RNA to protein.

HY-126406

Tirandamycin A	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Anti-parasitic Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial DNA/RNA Synthesis Parasite Antibiotic
Tirandamycin A, an antibiotic, is a bacterial RNA polymerase inhibitor. Tirandamycin A has antiamoebic and antibacterial properties .

HY-P2450

Leucinostatin A Antibiotic P168	Infection Natürliche Produkte Microorganisms Classification of Application Fields Disease Research Fields Source Classification	Fungal Antibiotic
Leucinostatin A (Antibiotic P168) is a nonapeptide exerting a remarkable activity especially against Candida albicans and Cryptococcus neoformans. Leucinostatin A is a hydrophobic nonapeptide antibiotic. Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells. Antiprotozoal activies .

HY-N6739R

Beauvericin (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Macrolide Antibiotics Antibiotics Antibacterial Disease Research Endogenous metabolite Source Classification	Reference Standards Bacterial Apoptosis Fungal PI3K Akt TNF Receptor Interleukin Related
Doxycycline (monohydrate) (Standard) is the analytical standard of Doxycycline (monohydrate). This product is intended for research and analytical applications. Doxycycline monohydrate is an antibiotic and broad-spectrum metalloproteinase (MMP) inhibitor .

HY-N14726

Primocarcin	Natürliche Produkte Microorganisms Source Classification	Antibiotic Bacterial
Primocarcin is an antibiotic that inhibits Ehrlich ascites cancer .

Art. -Nr.	Produktname	Chemical Structure

HY-B0322S

Sulfamethoxazole-d4

1 Publications Verification

Sulfamethoxazole-d₄ (Ro 4-2130-d₄) is a deuterium labeled Sulfamethoxazole (HY-B0322). Sulfamethoxazole (Ro 4-2130) is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis .

HY-N1423S

Glycocholic acid-d4

Glycocholic acid-d₄ is the deuterium labeled Glycocholic acid (HY-N1423). Glycocholic acid is a bile acid derivative. Glycocholic acid downregulates MDR1, Bcl-2, MRP1, MRP2 and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and S1PR2. Glycocholic acid inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis, and enhances chemosensitivity. Glycocholic acid modulates related bile acid receptor signaling. Glycocholic acid suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA).

HY-B0510S

Trimethoprim-d9
Trimethoprim-d₉ is the deuterium labeled Trimethoprim. Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for urinary tract infections, Shigellosis and Pneumocystis pneumonia treatment .

HY-17025S

Rifabutin-d7
Rifabutin-d₇ is the deuterium labeled Rifabutin. Rifabutin (Ansamycin) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits DNA-dependent RNA polymerase.

HY-17586AS

Dalbavancin-d6
Dalbavancin-d₆ is the deuterium labeled Dalbavancin . Dalbavancin (MDL-63397) is a semisynthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin inhibits Staphylococcus aureus and Bacillus anthracis with MIC90s of 0.06 μg/mL and 0.25 μg/mL, respectively .

HY-10394S

Linezolid-d3 1 Publications Verification
Linezolid-d₃ (PNU-100766-d₃) is a deuterium labeled Linezolid (PNU-100766). Linezolid is a synthetic antibiotic that acts by inhibiting the initiation of bacterial protein synthesis .

HY-B0671S

Vancomycin-d12 TFA
Vancomycin-d₁₂ TFA is a deuterium labeled Vancomycin (HY-B0671). Vancomycin is an antibiotic for the treatment of bacterial infections. It acts by inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin also alters the permeability of the cell membrane and selectively inhibits ribonucleic acid synthesis .

HY-N0565S1

Doxycycline-d3 (hyclate) (major)

Doxycycline-d₃ hyclate (major) is the deuterium labeled Doxycycline hyclate (HY-N0565B). Doxycycline hyclate is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline hyclate is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline hyclate also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline hyclate induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline hyclate also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline hyclate has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers .

HY-B1743S

Puromycin-d3 3 Publications Verification
Puromycin-d₃ is the deuterium labeled Puromycin. Puromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis.

HY-W654023

Tazobactam-15N3 sodium
Tazobactam- ¹⁵N₃ sodium is the ¹⁵N labeled isotope of Tazobactam sodium (HY-W009168) . Tazobactam sodium is an antibiotic of the beta-lactamase inhibitor class.

HY-B0132S

Norfloxacin-d5
Norfloxacin-d₅ is the deuterium labeled Norfloxacin. Norfloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase .

HY-B0220S1

Erythromycin-13C,d3

Erythromycin- ¹³C,d₃ is the ¹³C- and deuterium labeled Erythromycin. Erythromycin is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin acts by binding to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid .

HY-143831S

Cefepime-d8 sulfate

Cefepime-d₈ (BMY-28142-d₈) sulfate is deuterium labeled Cefepime sulfate. Cefepime sulfate is a broad-spectrum, blood-brain barrier-permeable cephalosporin antibiotic with hPON1 inhibitory activity, with an IC₅₀ of 21.115 mM and a K_i of 35.092 mM. Cefepime sulfate inhibits hPON1 via a non-competitive mechanism and blocks GABA_A receptors. Cefepime sulfate penetrates the outer membrane of Gram-negative bacteria, inhibits the growth of Gram-positive and Gram-negative bacteria, and does not induce the production of β-lactamase.

HY-106257S

Ceftolozane-d6 TFA
Ceftolozane-d₆ TFA is a deuterated labeled Ceftolozane TFA (HY-106257A). Ceftolozane TFA is a cephalosporin antibiotic that can be used to inhibit Gram-negative bacterial infections. Ceftolozane TFA can be used to synthesize new antibiotic that are more potent and safer .

HY-W653977

Chlortetracycline-13C,d3 hydrochloride

Chlortetracycline-13C,d3 hydrochloride (7-Chlorotetracycline-13C,d3 hydrochloride) is the 13C- and deuterium labeled Chlortetracycline hydrochloride (HY-B1327). Chlortetracycline hydrochloride is an orally active, selective antibiotic, that inhibits methanogenic bacteria through inhibition of bacterial protein synthesis. Chlortetracycline hydrochloride is a specific and potent calcium ionophore antibiotic, that inhibits binding of aminoacyl-tRNA to ribosomes .

HY-B1327S

Chlortetracycline-d6 hydrochloride
Chlortetracycline-d₆ (hydrochloride) is the deuterium labeled Chlortetracycline hydrochloride. Chlortetracycline hydrochloride (7-Chlorotetracycline hydrochloride) is a specific and potent calcium ionophore antibiotic, inhibits binding of aminoacyl-tRNA to ribosomes.

HY-B0275S

Oxytetracycline-d6
Oxytetracycline-d₆ is deuterium labeled Oxytetracycline. Oxytetracycline is an antibiotic belonging to the tetracycline class. Oxytetracycline potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline also possesses anti-HSV-1 activity .

HY-B0510S2

Trimethoprim-d3
Trimethoprim-d₃is the deuterium labeled Trimethoprim. Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for urinary tract infections, Shigellosis and Pneumocystis pneumonia treatment .

HY-B1244S

Dimetridazole-d3 1 Publications Verification
Dimetridazole-d₃ (1,2-Dimethyl-5-nitroimidazole-d₃) is a deuterium labeled Dimetridazole (HY-B1244). Dimetridazole is a nitroimidazole *antibiotic. Dimetridazole inhibits* protein synthesis in cultures of Campylobacter jejuni. Dimetridazole is genotoxic. Dimetridazole can be used in the research of protozoal and bacterial infections .

HY-B0220S2

Erythromycin-d3

Erythromycin-d₃ is the deuterium labeled Erythromycin . Erythromycin is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid. Erythromycin also exhibits antitumor and neuroprotective effect in different fields of research .

HY-W654100

Cefepime-d3 sulfate

Cefepime-d₃ (BMY-28142-d₃) sulfate is deuterium labeled Cefepime sulfate. Cefepime sulfate is a broad-spectrum, blood-brain barrier-permeable cephalosporin antibiotic with hPON1 inhibitory activity, with an IC₅₀ of 21.115 mM and a K_i of 35.092 mM. Cefepime sulfate inhibits hPON1 via a non-competitive mechanism and blocks GABA_A receptors. Cefepime sulfate penetrates the outer membrane of Gram-negative bacteria, inhibits the growth of Gram-positive and Gram-negative bacteria, and does not induce the production of β-lactamase.

HY-B0322S1

Sulfamethoxazole-13C6

Sulfamethoxazole- ¹³C₆ (Ro 4-2130- ¹³C₆) is a ¹³C labeled Sulfamethoxazole (HY-B0322). Sulfamethoxazole (Ro 4-2130) is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis .

HY-15142AS1

Doxorubicin-13C,d3 TFA
Doxorubicin- ¹³C,d₃ TFA is the deuterium and ¹³C labeled Doxorubicin. Doxorubicin (Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin inhibits topoisomerase II with an IC50 of 2.67 μM, thus stoppin

HY-B0275S1

Oxytetracycline-d3

Oxytetracycline-d₃ is the deuterium labeled Oxytetracycline (HY-B0275). Oxytetracycline is an antibiotic belonging to the tetracycline class. Oxytetracycline potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline also possesses anti-HSV-1 activity .

HY-B1455S1

Clindamycin-13C,d3

Clindamycin- ¹³C,d₃ is the ¹³C- and deuterium labeled Clindamycin. Clindamycin is an orally active and broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin can inhibit bacterial protein synthesis, possessing the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla). Clindamycin also can be used for researching malaria .

HY-17412AS

Minocycline-d6

Minocycline-d₆ is deuterium labeled Minocycline (HY-17412A). Minocycline is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .

HY-W653936

Cephalexin-d5 hydrate

Cephalexin-d₅ (hydrate) is deuterium labeled Cephalexin (monohydrate). Cephalexin (Cefalexin) monohydrate is a potent, orally active new semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin (Cefalexin) monohydrate has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin (Cefalexin) monohydrate targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin (Cefalexin) monohydrate is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al .

HY-B0688S2

Dapsone-13C12

Dapsone- ¹³C₁₂ is the ¹³C₁₂ labeled Dapsone (HY-B0688). Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .

HY-N0565AS

Doxycycline-d3 (hydrochloride)

Doxycycline-d₃ hydrochloride is deuterium labeled Doxycycline hydrochloride (HY-N0565A). Doxycycline hydrochloride is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline hydrochloride is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline hydrochloride also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline hydrochloride induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline hydrochloride also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline hydrochloride has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers .

HY-N0565S3

Doxycycline-13C,d3

Doxycycline- ¹³C,d₃ is ¹³C and deuterium labeled Doxycycline (HY-N0565). Doxycycline is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers .

HY-10394S1

Linezolid-d8
PNU-100766-d₈ is deuterated labeled Linezolid (HY-10394). Linezolid (PNU-100766) is the first member of the class of oxazolidinone synthetic antibiotic. Linezolid acts by inhibiting the initiation of bacterial protein synthesis. Linezolid is used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics .

HY-B0555BS

Nafcillin-d5 sodium
Nafcillin-d₅ (sodium) is the deuterium labeled Nafcillin sodium. Nafcillin sodium, an antibiotic, is a reversible inhibitor of β-lactamase. Nafcillin sodium can be used for the research of staphylococcal infections .

HY-18258S

Berberine-d6 chloride
Berberine-d₆ (chloride) is the deuterium labeled Berberine chloride. Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties .

HY-B0946S

Sulfamonomethoxine-d4
Sulfamonomethoxine-d₄ is a deuterium labeled Sulfamonomethoxine (HY-B0946). Sulfamonomethoxine is an orally active sulfonamide antibiotic for veterinary use. Sulfamonomethoxine is also an inhibitor of dihydropteroate synthetase, which can block the synthesis of folic acid. Sulfamonomethoxine has antibacterial activity .

HY-B0975S1

Penicillin V-d5 potassium
Penicillin V-d₅ (potassium) is the deuterium labeled Penicillin V Potassium . Penicillin V Potassium (Phenoxymethylpenicillin potassium salt) is an orally active antibiotic. Penicillin V Potassium inhibits the growth of Streptococci, C. difficile and S. aureus. Penicillin V Potassium can be used for the research of otitis, sinusitis, pharyngitis and tonsillitis .

HY-B0688S

Dapsone-d8

Dapsone-d₈ is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities . Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases .

HY-B1743AS

Puromycin-d3 dihydrochloride 3 Publications Verification
Puromycin-d₃ (dihydrochloride) is the deuterium labeled Puromycin dihydrochloride. Puromycin dihydrochloride (CL13900 dihydrochloride), an aminonucleoside antibiotic, inhibits protein synthesis .

HY-B0526S

Flumequine-13C3
Flumequine- ¹³C₃ is the ¹³C₃ labeled Flumequine. Flumequine (R-802) is a quinolone antibiotic, and acts as a topoisomerase II inhibitor, with an IC50 of 15 μM (3.92 μg/mL).

HY-B0239S3

Chloramphenicol-d4
Chloramphenicol-d₄ is deuterium labeled Chloramphenicol. Chloramphenicol, a broad-spectrum antibiotic, acts as a potent inhibitor of bacterial protein biosynthesis . Chloramphenicol acts primarily on the 50S subunit of bacterial 70S rihosomes and inhibits peptide bond formation by suppressing peptidyl transferase activity .

HY-B1002S

Oxolinic acid-d5
Oxolinic acid-d₅ is the deuterium labeled Oxolinic acid. Oxolinic acid is an antibiotic against both Gram-negative and Gram-positive bacteria. Oxolinic acid can be used for the research of acute and chronic urinary tract infections. Oxolinic acid is a DNA/RNA synthesis inhibitor. Oxolinic acid acts a dopamine uptake inhibitor and stimulants locomotor effect in mice .

HY-B1455S

Clindamycin-d3 hydrochloride

Clindamycin-d₃ (hydrochloride) is the deuterium labeled Clindamycin. Clindamycin is an orally active and broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin can inhibit bacterial protein synthesis, possessing the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla). Clindamycin also can be used for researching malaria .

HY-B1350S

Fusidic acid-d6
Fusidic acid-d₆ is the deuterium labeled Fusidic acid. Fusidic acid (Fusidate) a bacteriostatic antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids. Fusidic acid has no corticosteroid effects. Fusidic acid inhibits the growth of bacteria by preventing the release of translation elongation factor G (EF-G) from the ribosome .

HY-W654130

Daunorubicin-13C,d3

Daunorubicin- ¹³C,d₃ is ¹³C and deuterium labeled Daunorubicin. Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

HY-B1418S2

Tazobactam-15N,d2
Tazobactam- ¹⁵N,d₂ (CL-298741- ¹⁵N,d₂) is ¹⁵N and deuterium labeled Tazobactam. Tazobactam (CL-298741) is a potent β-lactamases inhibitor and penicillin antibiotic. Tazobactam has antibacterial activity. Tazobactam can be used for pneumonia research .

HY-B0398S

Nalidixic Acid-d5

Nalidixic Acid-d₅ is the deuterium labeled Nalidixic acid. Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria .

HY-B0510S3

Trimethoprim-13C3

Trimethoprim- ¹³C₃ is the deuterium labeled Trimethoprim (HY-B0510) . Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim can inhibit infection of Influenza A virus in chick embryo when combinated with zinc .

HY-W755036

Oxytetracycline-13C,d3 hydrochloride

Oxytetracycline-13C,d3 hydrochloride is the 13C- and deuterium labeled Oxytetracycline hydrochloride (HY-B0275A). Oxytetracycline hydrochloride is an antibiotic that exhibits board-spectrum antibacterial activity. Oxytetracycline hydrochloride is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline hydrochloride also possesses anti-HSV-1 activity .

HY-B0905S

Tilmicosin-d3

Tilmicosin-d3 is the deuterium labeled Tilmicosin. Tilmicosin (LY-177370) is an orally active calcium channel antagonist and macrolide antibiotic with antimicrobial activity. Tilmicosin mainly acts on the 50S subunit of bacterial ribosomes, inhibiting protein synthesis. Tilmicosin is effective in the treatment of respiratory diseases in livestock such as cattle, sheep and pigs. In addition, Tilmicosin has immunomodulatory and anti-inflammatory effects .

HY-B0688S1

Dapsone-d4

Dapsone-d₄ is the deuterium labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities . Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .

HY-B1075AS

(Rac)-Fosfomycin (benzylamine)-13C3

(Rac)-Fosfomycin (benzylamine)- ¹³C₃ is the ¹³C labeled Fosfomycin . Fosfomycin (MK-0955) is a broad-spectrum antibiotic. Fosfomycin can cross blood-brain barrier penetrating, and irreversibly inhibits an early stage in cell wall synthesis. Fosfomycin shows anti-bacteria activity for a range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria .

Targets Recommended: Antibiotic

Art. -Nr.	Produktname	Target	Forschungsgebiete	Chemical Structure

HY-13067G

Celastrol Tripterine; Tripterin	Endogenous Metabolite Proteasome Antibiotic Apoptosis Bacterial Autophagy Mitophagy	Infection Inflammation/Immunology Cancer
Celastrol (GMP) (Tripterine (GMP)) is Celastrol (HY-10227) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Celastrol (Tripterine;Tripterin) is a proteasome inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified 20S proteasome with IC₅₀ of 2.5 μM. In addition, Celastrol is also an *antibiotic* with potent antimicrobial activity against standard and clinical methicillin-resistant Staphylococcus aureus (MRSA) strains, inducing oxidative stress and inhibiting DNA synthesis by binding to P5CDH .

HY-N0565AG

Doxycycline (hydrochloride)	Apoptosis MMP Akt PI3K	Infection Neurological Disease Inflammation/Immunology Cancer
Doxycycline hydrochloride GMP is Doxycycline (hydrochloride) (HY-N0565A) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Doxycycline hydrochloride is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline hydrochloride is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline hydrochloride also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline hydrochloride induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline hydrochloride also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline hydrochloride has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers .

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