1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Tebipenem pivoxil

Tebipenem pivoxil (Synonyms: L084)

Cat. No.: HY-B0396 Purity: ≥98.0%
Handling Instructions

Tebipenem pivoxil (L084) is an orally active antibiotic against a variety of pathogenic bacteria. Tebipenem pivoxil binds penicillin-binding protein (PBP), thereby inhibiting cell wall synthesis.

For research use only. We do not sell to patients.

Tebipenem pivoxil Chemical Structure

Tebipenem pivoxil Chemical Structure

CAS No. : 161715-24-8

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 109 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 109 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 99 In-stock
Estimated Time of Arrival: December 31
10 mg USD 132 In-stock
Estimated Time of Arrival: December 31
50 mg USD 275 In-stock
Estimated Time of Arrival: December 31
100 mg USD 495 In-stock
Estimated Time of Arrival: December 31
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Description

Tebipenem pivoxil (L084) is an orally active antibiotic against a variety of pathogenic bacteria. Tebipenem pivoxil binds penicillin-binding protein (PBP), thereby inhibiting cell wall synthesis[1].

In Vitro

Tebipenem pivoxil (0-128 μg/mL; 18–24 h) displays excellent antibacterial activity against a variety of pathogenic bacteria[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Gram-positive and Gram-negative bacteria
Concentration: 0-128 μg/mL
Incubation Time: 18–24 h
Result: Showed inhibition with MIC50s below 64 μg/mL against tested Gram-positive and Gram-negative bacteria.
In Vivo

Tebipenem pivoxil (L084) (0-4.00 g/kg; p.o.; once) shows minimal lethal dosage (MLD) of 4.00 g/kg and the maximum tolerance dosage (MTD) of 3.40 g/kg in mice[1].
Tebipenem pivoxil (50 and 100 mg/kg; p.o.; once) significantly protects the sepsis mice challenged with various pathogenic bacteria[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: KM mice weighing 18–22 g[1]
Dosage: 2.89, 3.40 and 4.00 g/kg
Administration: Oral administration (tablet), once
Result: Within the 14-day observation period, only one mouse was dead in the maximum oral dosage (4.00 g/kg). The minimal lethal dosage (MLD) was 4.00 g/kg and the maximum tolerance dosage (MTD) in the mice was 3.40 g/kg. Showed dose-dependent liver and kidney damage.
Animal Model: ICR mice, sepsis mouse models[1]
Dosage: 50 and 100 mg/kg
Administration: Oral administration (tablet), once
Result: Significantly increased the survival number of the sepsis mice within a 168 h observation period.
Clinical Trial
Molecular Weight

497.63

Formula

C22H31N3O6S2

CAS No.
SMILES

O=C(C(N1C2=O)=C(SC3CN(C4=NCCS4)C3)[[email protected]](C)[[email protected]]1([H])[[email protected]@]2([H])[[email protected]](O)C)OCOC(C(C)(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 150 mg/mL (301.43 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0095 mL 10.0476 mL 20.0953 mL
5 mM 0.4019 mL 2.0095 mL 4.0191 mL
10 mM 0.2010 mL 1.0048 mL 2.0095 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: ≥98.0%

References
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Tebipenem pivoxil
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