1. Anti-infection
    Metabolic Enzyme/Protease
  2. Fungal
    Mitochondrial Metabolism
    Antibiotic
  3. Myxothiazol

Myxothiazol 

Cat. No.: HY-112177 Purity: >99.0%
Handling Instructions

Myxothiazol, an antifungal antibiotic, is a mitochondrial electron transport chain complex III (bc1 complex) inhibitor. Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml.

For research use only. We do not sell to patients.

Myxothiazol Chemical Structure

Myxothiazol Chemical Structure

CAS No. : 76706-55-3

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Description

Myxothiazol, an antifungal antibiotic, is a mitochondrial electron transport chain complex III (bc1 complex) inhibitor. Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml[1][2].

In Vitro

Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml[2].
Myxothiazol binds to the ubiquinol oxidation site Qo of complex III and blocks electron transfer from ubiquinol to cytochrome b and thus inhibits complex III activity[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Myxothiazol (i.p.; 0.56 mg/kg; daily for 4 days)-induced complex III inhibition can be induced in mice for four days in a row without overt hepatotoxicity or lethality[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl/J6 mice[3]
Dosage: 0.56 mg/kg
Administration: I.p.; 24 hours intervals for at most 4 times
Result: A reversible complex III activity decrease to 50% of control value occurred at 2 h post-injection. At 74 h only minor histological changes in the liver were found, supercomplex formation was preserved and no significant changes in the expression of genes indicating hepatotoxicity or inflammation were found.
Molecular Weight

487.68

Formula

C₂₅H₃₃N₃O₃S₂

CAS No.

76706-55-3

SMILES

C[[email protected]](C1=NC(C2=NC(/C=C/[[email protected]](OC)[[email protected]@H](C)/C(OC)=C\C(N)=O)=CS2)=CS1)/C=C/C=C/C(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: >99.0%

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Keywords:

MyxothiazolFungalMitochondrial MetabolismAntibioticfungimitochondrialelectrontransportchainrespiratorytoxicityInhibitorinhibitorinhibit

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Product Name:
Myxothiazol
Cat. No.:
HY-112177
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