76706-55-3
76706-55-3
Chemical Structure
Myxothiazol
- CAS No.: 76706-55-3
- Formula:C25H33N3O3S2
- Molecular Weight:487.68
IUPAC Name: (2E,4R,5S,6E)-3,5-dimethoxy-4-methyl-7-(2'-((S,3E,5E)-7-methylocta-3,5-dien-2-yl)-[2,4'-bithiazol]-4-yl)hepta-2,6-dienamide
InChIKey: XKTFQMCPGMTBMD-FYHMSGCOSA-N
SMILES: C[C@H](C1=NC(C2=NC(/C=C/[C@H](OC)[C@@H](C)/C(OC)=C\C(N)=O)=CS2)=CS1)/C=C/C=C/C(C)C
Biological Activity: Myxothiazol, an antifungal antibiotic, is a mitochondrial electron transport chain complex III (bc1 complex) inhibitor. Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Myxothiazol | 99.14% | Myxothiazol, an antifungal antibiotic, is a mitochondrial electron transport chain complex III (bc1 complex) inhibitor. Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.75
HY-N14135Cystothiazole A -
Similarity Score 0.68
HY-N14249Melithiazole B -
Similarity Score 0.68
HY-N14149Cystothiazole B -
Similarity Score 0.64
HY-N14252Melithiazole N -
Similarity Score 0.49
HY-N14248Melithiazole A -
Similarity Score 0.49
HY-N14250Melithiazole C -
Similarity Score 0.48
HY-N14251Melithiazole K -
Similarity Score 0.41
HY-N14043Crocacin C -
Similarity Score 0.38
HY-N14040Crocacin B -
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References
- [1]. Thierbach G, et al. Myxothiazol, a new antibiotic interfering with respiration. Antimicrob Agents Chemother. 1981;19(4):504-507. [Content Brief]
- [2]. von Jagow G,et al. An inhibitor of mitochondrial respiration which binds to cytochrome b and displaces quinone from the iron-sulfur protein of the cytochrome bc1 complex. J Biol Chem. 1984;259(10):6318-6326. [Content Brief]
